Abstract: There is disclosed a transdermal drug delivery system wherein a drug or therapeutic agent is encapsulated in a water soluble carbohydrate. The carbohydrate-encapsulated drug or therapeutic agent, in the form of finely divided particles, is suspended in a cyanoacrylate ester which is applied to the skin of a mammal. Moisture on the skin and contact with skin tissue causes the cyanoacrylate to polymerize and the moisture on the skin also dissolves the carbohydrate permitting the drug or therapeutic agent, over time, to enter the body system through the pores of the skin.