Abstract: The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.

Abstract: Compounds which bind to opioid receptors are provided. In a preferred embodiment of the invention, the compounds are opioid receptor antagonists. The present invention also provides methods of treating conditions which are mediated by an opioid receptor.

Abstract: Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.

Abstract: In embodiments of the invention, a radiosensitizer or other agent is relatively uniformly accumulated in the cells of a tumor. An external monochromatic x-ray beam, which is tuned to a predetermined energy level associated with k-edge effects in the agent, is then directed to the tumor. The monochromatic x-ray beam activates the release of additional localized radiation from the agent. The additional radiation destroys the DNA of at least some tumor cells, making those tumor cells incapable of reproduction and repair. In embodiments of the invention, a single monochromatic x-ray beam source is used for both imaging and radiotherapy.

Abstract: A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for determining effective doses of new drug candidates in human populations. In addition, the high specificity, slow onset and long duration of the action of these compounds at the receptors makes them particularly well suited for therapeutic uses, for example as substitute medication for psychostimulant abuse. Some of these compounds may be useful in treating Parkinson's Disease or depression, by virtue of their inhibitory properties at monoamine transporters.

Abstract: The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man monoclonal antibodies directed to drugs of abuse. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR3 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: A three-dimensional imaging device comprising a stationary monochromatic beam source projecting a beam onto a plurality of reflective mosaic crystals, wherein the plurality of mosaic crystals reflect the beam through a stationary object onto a stationary detector. A way for scanning the object includes moving the entire set of the mosaic crystals linearly along a line in the plane of the crystals, and rotating the entire plurality of crystals about an axis through the stationary beam source while maintaining the plurality of crystals in a fixed relative orientation. A potential application of the invention is to improve the accuracy of mammography in the diagnosis of breast cancer.

Abstract: A method and apparatus for detecting internal bio-deterioration in round wood used in various applications (e.g. utility poles, pier pilings, round wood beams, posts and poles in structures, and living trees). The method includes the steps of securing a pulsing transducer adjacent one point on the surface of the round wood and securing a receiving transducer substantially diametrically opposite to the pulsing transducer. The pulsing transducer transmits ultrasonic signals through the round wood, which propagate through possibly deteriorated areas within the round wood. The receiving transducer receives the propagating ultrasonic signals, and a plurality of acousto-ultrasonic parameters contained in the received ultrasonic signals are processed and analyzed. The processing step includes the step of storing the averaged signals, and processing the stored signals on a real time basis to determine the acousto-ultrasonic parameters in the time and frequency domains.

Abstract: A method and apparatus for detecting internal bio-deterioration in round wood used in various applications (e.g. utility poles, pier pilings, round wood beams, posts and poles in structures, and living trees). The method includes the steps of securing a pulsing transducer adjacent one point on the surface of the round wood and securing a receiving transducer substantially diametrically opposite to the pulsing transducer. The pulsing transducer transmits ultrasonic signals through the round wood, which propagate through possibly deteriorated areas within the round wood. The receiving transducer receives the propagating ultrasonic signals, and a plurality of acousto-ultrasonic parameters contained in the received ultrasonic signals are processed and analyzed. The processing step includes the step of storing the averaged signals, and processing the stored signals on a real time basis to determine the acousto-ultrasonic parameters in the time and frequency domains.