Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

Abstract: An anchor including shape memory metals, shape memory polymers or a combination thereof. The anchor has surgical and nonsurgical uses.

Abstract: A multi-purpose detection circuit for object detection and vehicle position determination is described. For example, the circuit is configurable for detecting foreign metallic objects, living objects, and a vehicle or type of vehicle above an inductive wireless power transmitter. The circuit is also configurable for determining the vehicle's position relative to the inductive wireless power transmitter. An example apparatus includes a measurement circuit including a multiplexer, electrically connected to a plurality of inductive and capacitive sense circuits, for measuring one or more electrical characteristics in each of the inductive and capacitive sense circuits according to a predetermined time multiplexing scheme.

Abstract: The present invention is a fracture reduction device or system adapted for use in bone cavities. The current device is particularly useful in surgical procedures involving fractured bones.

Abstract: A threadless friction fit surgical implant suited for implantation or use in mammalian spinal or other boney tissues.

Abstract: The present invention is a process of making a patient-specific implant for a patient. The current process is adaptable to manufacture spinal and other implants for insertion into the patient.

Abstract: A joint implant adapted for use in joint surgeries. Among other things, the joint implant has an anterior cutting edge and a rotatable cutter supported by a rotatable shaft. When surgical parameters require, the shaft can be detached from the implant. The present implant can include a rotatable shaft that has a conduit and windows.

Abstract: The present invention is an implant for bone. The current implant is particularly useful in spinal surgical procedures.

Abstract: A surgical fastener combination for use in posterior surgeries requiring require fusion between the occiput and pelvis. Among other things, the surgical fastener combination includes first and second cutters.

Abstract: The present invention is an implant for bone. The current implant is particularly useful in spinal surgical procedures.

Abstract: An anchor including shape memory metals, shape memory polymers or a combination thereof. The anchor has surgical and nonsurgical uses.

Abstract: The present invention is an implant for bone. The current implant is particularly useful in spinal surgical procedures.

Abstract: A surgical fastener provided with a curved cutter, an anterior wedge-like tip and a surgeon facing end. Among other things, the surgical fastener's cutter can cut bone or other tissue.

Abstract: The present invention is an implant for bone. The current implant is particularly useful in spinal surgical procedures.

Abstract: A biocompatible construction adapted for use in joint surgeries. Among other things, the joint implant has an anterior cutting edge and a rotatable cutter distinct from the cutting edge. The rotatable cutter allows for graduated cutting of biological tissue or structure.

Abstract: A joint implant adapted for use in joint surgeries. Among other things, the joint implant has an anterior cutting edge and a rotatable cutter supported by a rotatable shaft. A polyaxial adapter can be incorporated into the current joint implant. The present implant can include a rotatable shaft that has a conduit and windows.

Abstract: The present invention is a fastener (30). The current fastener (30) is particularly useful in surgical procedures. Among other things, the surgical fastener (30) is provided with a conduit (50, 210) to dispense or carry biocompatible substances.

Abstract: The present invention is a fastener (30). The current fastener (30) is particularly useful in surgical procedures. Among other things, the surgical fastener (30) is provided with a conduit (50, 210) to dispense or carry biocompatible substances.

Abstract: A surgical fastener provided with a curved cutter, an anterior wedge-like tip and a surgeon facing end. Among other things, the surgical fastener's cutter can cut bone or other tissue.

Abstract: The present invention is an implant for bone. The current implant is particularly useful in spinal surgical procedures.