Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides BCMA-specific chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The engineered cells of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, engineered cells expressing the BCMA-specific chimeric antigen receptors of the invention are useful for the treatment of various cancers, including multiple myeloma.

Abstract: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides BCMA-specific chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The engineered cells of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, engineered cells expressing the BCMA-specific chimeric antigen receptors of the invention are useful for the treatment of various cancers, including multiple myeloma.

Abstract: Included are systems and methods for providing data. At least one embodiment of a method includes constructing, by a computing device, a segment line on a computer display of an image of a golf course, the segment line being constructed from a tee box on a golf hole to a green on the golf hole, the segment line bisecting a fairway of the hole; determining at least one lay up position on the segment line, the at least one lay up position indicating a predetermined distance from the green; and providing the at least one lay up position to a user device, the user device configured to determine a distance between the user device and the lay up position.

Abstract: Included are systems and methods for providing data. At least one embodiment of a method includes constructing, by a computing device, a segment line on a computer display of an image of a golf course, the segment line being constructed from a tee box on a golf hole to a green on the golf hole, the segment line bisecting a fairway of the hole; determining at least one lay up position on the segment line, the at least one lay up position indicating a predetermined distance from the green; and providing the at least one lay up position to a user device, the user device configured to determine a distance between the user device and the lay up position.

Abstract: Included are systems and methods for providing data. At least one embodiment of a method includes constructing, by a computing device, a segment line on a computer display of an image of a golf course, the segment line being constructed from a tee box on a golf hole to a green on the golf hole, the segment line bisecting a fairway of the hole; determining at least one lay up position on the segment line, the at least one lay up position indicating a predetermined distance from the green; and providing the at least one lay up position to a user device, the user device configured to determine a distance between the user device and the lay up position.