Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: The present disclosure relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support.

Abstract: The present disclosure relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support.

Abstract: The invention relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support. A first aspect is the modification of the silica support with at least 11 wt % titania to prevent the formation of cobalt silicates, thereby limiting the deactivation resulting from the silicate formation. A second aspect is the provision of C03O4 particles highly dispersed on the catalyst support with an average particle diameter of the cobalt oxide particle of less than 12 nm in order to improve catalytic activity and selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminum metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminium metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: The invention relates to improvements in the design of Fischer-Tropsch catalysts comprising a support and cobalt on the support. A first aspect is the modification of the silica support with at least 11 wt % titania to prevent the formation of cobalt silicates, thereby limiting the deactivation resulting from the silicate formation. A second aspect is the provision of C03O4 particles highly dispersed on the catalyst support with an average particle diameter of the cobalt oxide particle of less than 12 nm in order to improve catalytic activity and selectivity.

Abstract: A method for the preparation of a modified catalyst support comprising: (a) treating a catalyst support material with an aqueous solution or dispersion comprising one or more zirconium metal sources, chromium metal sources, manganese metal sources and aluminium metal sources, and one or more polar organic compounds; and (b) drying the treated support, and (c) optionally calcining the treated support. Also provided are catalyst support materials obtainable by the methods, and catalysts prepared from such supports.

Abstract: A laser gyro for detecting rates of rotating the gyro having a primary dither means for eliminating lock-in at low rates of rotation and a secondary dither means for eliminating nonlinearities in the gyro output when the input rate is a harmonic of the primary dither frequency. The gyro includes a body having a polygonal shaped cavity therein with a mirror disposed at each of the corners thereof to form a closed loop path for two counter-rotating beams. The primary dither includes means for dithering two mirrors 180.degree. out of phase to maintain the cavity path length constant. The secondary dither includes a current dither for differentially modulating the current in each leg of the gyro to randomly null nonlinearities in the gyro output.