Abstract: Devices, systems, implants and methods for achieving ligament fixation are disclosed. An implant includes a head member and an anchor member coupled to the head member. The implant includes tension member that couples the head member to the anchor member. The head member and the anchor member include a cannulation that receives the tension member therein. The implant may include a coupling member positioned between and coupling the head member and the anchor member, the coupling member including a cannulation that receives the tension member therethrough. Insertion instruments for inserting an implant for ligament fixation are also disclosed. Methods of using an implant for achieving ligament fixation are also disclosed.

Abstract: Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.

Abstract: Various implementations described herein are directed to an integrated circuit having first latch circuitry with multiple first latches that latch multiple input data signals. The integrated circuit may include second latch circuitry having a single second latch that receives the latched multiple input data signals from the multiple first latches and outputs a single latched data signal based on the latched multiple input data signals. The integrated circuit may include intermediate logic circuitry that is coupled between the first latch circuitry and the second latch circuitry. The intermediate logic circuitry may receive and combine the multiple input data signals from the first latch circuitry into a single data signal that is provided to the single second latch of the second latch circuitry for output as the single latched data signal.

Abstract: Techniques for predicting a user response to content are described. According to various embodiments, a configuration file is accessed, where the configuration file includes a user-specification of raw data accessible via external data sources and raw data encoding rules. In some embodiments, the raw data includes raw member data associated with a particular member and raw content data associated with a particular content item. Thereafter, source modules encode the raw data from the external data sources into feature vectors, based on the raw data encoding rules. An assembler module assembles one or more of the feature vectors into an assembled feature vector, based on user-specified assembly rules included in the configuration file. A prediction module performs a prediction modeling process based on the assembled feature vector and a prediction model, to predict a likelihood of the particular member performing a particular user action on the particular content item.

Abstract: Systems and methods are described for operating an imaging system that includes an intra-oral imaging sensor and an electronic processor. The intra-oral imaging sensor includes a housing, an image sensing component at least partially housed within the housing, and a multi-dimensional sensor at least partially housed within the housing. The electronic processor is configured to receive an output of the multi-dimensional sensor indicative of movement of the intra-oral imaging sensor. The output is compared to predetermined movement criteria indicative of a type of movement and, in response to determining that the type of movement of the imaging sensor has occurred, the electronic processor alters the operation of the imaging system.

Abstract: Implants, devices, and methods for maintaining, correcting and/or fusing joint deformities are disclosed. The implant a first member, a second member, and an insert with a top surface and a bottom surface. The top surface couples to the first member and the bottom surface engages the second member. Kits and methods of using the implants for maintaining, correcting and/or fusing joint deformities are also disclosed.

Abstract: A backflow prevention assembly is configurable with varying lay-lengths and orientations. The assembly includes coupling assemblies and valve bodies that adjust in length and/or rotation to allow for the varying lay-lengths and orientations of the backflow prevention valves and assemblies with and without certification. A coupling assembly is connected to a backflow prevention valve and includes an outer sleeve and an inner sleeve that is slidingly received within the outer sleeve. The lay-length is adjusted by slidably moving the inner and outer sleeves with respect to one another.

Abstract: A vertical bundle air-cooled heat exchanger, a finned tube assembly for an air cooled condenser and method for forming the same, and a system for removing thermal energy generated by radioactive materials. In one aspect, an air cooled condenser sized for industrial and commercial application includes an inlet steam distribution header for conveying steam, a condensate outlet header for conveying condensate, an array of tube bundles each having a plurality of finned tube assemblies having a bare steel tube with an exposed outer surface and a set of aluminum fins brazed directly onto the tube by a brazing filler metal. The steel tubes may be spaced apart by the aluminum fins and have an inlet end fluidly coupled to the inlet steam distribution header and an outlet end fluidly coupled to the outlet header. A forced draft fan may be arranged to blow air through the tube bundles.

Abstract: A method for establishing a communication session between a public switched telephone network (PSTN) endpoint and a Web real time communications (WebRTC) endpoint includes receiving, by a PSTN microservice (MS), a session initiation protocol (SIP) based signaling message from a PSTN endpoint and acquiring, by the PSTN MS, endpoint context attribute information from the SIP based signaling message. The method further includes generating, by the PSTN MS, a WebRTC based signaling message that includes an address identifier of an associate endpoint (AE) that is associated with the context attribute information and transmitting, by the PSTN MS, the WebRTC based signaling message to the AE to initiate a call session between the PSTN endpoint and the AE.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A backflow prevention assembly is configurable with varying lay-lengths and orientations. The assembly includes coupling assemblies and valve bodies that adjust in length and/or rotation to allow for the varying lay-lengths and orientations of the backflow prevention valves and assemblies with and without certification. A coupling assembly is connected to a backflow prevention valve and includes an outer sleeve and an inner sleeve that is slidingly received within the outer sleeve. The lay-length is adjusted by slidably moving the inner and outer sleeves with respect to one another.

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: Various implementations described herein are directed to an integrated circuit having first latch circuitry with multiple first latches that latch multiple input data signals. The integrated circuit may include second latch circuitry having a single second latch that receives the latched multiple input data signals from the multiple first latches and outputs a single latched data signal based on the latched multiple input data signals. The integrated circuit may include intermediate logic circuitry that is coupled between the first latch circuitry and the second latch circuitry. The intermediate logic circuitry may receive and combine the multiple input data signals from the first latch circuitry into a single data signal that is provided to the single second latch of the second latch circuitry for output as the single latched data signal.

Abstract: Some embodiments are directed to a neural network training device for training a neural network. At least one layer of the neural network layers is a projection layer. The projection layer projects a layer input vector (x) of the projection layer to a layer output vector (y). The output vector (y) sums to the summing parameter (k).

Abstract: An object inspection system and a method for detecting defects which utilizes a plurality of cameras and lights to capture images of a portion of an object and which uses the captured images to determine the presence of a defect upon a surface, such as surface, of the object and which may communicated the location of the identified defect to an automated defect repair assembly.

Abstract: A method for preparing a sample for chromatographic separation processes, in which a sample vessel is partially filled with a substance to be examined and is closed, is described. The substance to be examined is subjected to a thermo-chemical reaction in which at least one sample component is converted into another substance, and in which by use of a removing device samples are removed from the sample vessel for analytical examination. Also, the sample vessel forms a cavity, into which the substance to be examined is introduced as a core and a heating section for indirect heat transfer is applied along the filling of substance to be examined.

Abstract: An autonomous aerial vehicle for ventilating persons. The ventilation becomes necessary as a result of fires, accidents, or medical emergencies. In these and comparable cases, the aerial vehicle aids for ventilating a person quickly and independently of the transport links of a location or the traffic situation at the time so the state of the person is stabilized until the arrival of an emergency doctor or other rescue workers and the chances of survival improves. The aerial vehicle provides positional determination inside and/or outside buildings, recording of the surrounding area, ventilation of at least one person, and a communication method or mechanism.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.