Abstract: DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. We apply a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients. Measurements of ctDNA can be used to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic approach can be generally applied.

Abstract: Known infrared radiators have a moulded body, which has a radiation surface that emits short-wave or medium-wave infrared radiation with a first peak emission wavelength. In order to provide, proceeding therefrom, an infrared radiator with an emissions spectrum which is well matched to absorption characteristics with a maximum around 2750 nm, and which furthermore can be operated with a high electrical power density, and with which the warming-up time in industrial applications, such as, for example, drying of inks, joining of plastics or bending of glass, can be shortened, according to the invention a radiation converter material is applied to at least a part of the radiation surface and, as a consequence of heating by the infrared radiation of the first peak emission wavelength, emits infrared radiation with a second peak emission wavelength which is of a longer wavelength than the first peak emission wavelength.

Abstract: A method, computer program product, and computing system for: receiving an initial portion of an encounter record; processing the initial portion of the encounter record to generate initial content for a medical report; receiving one or more additional portions of the encounter record; and processing the one or more additional portions of the encounter record to modify the medical report.

Abstract: A method, computer program product, and computer system for encoding, by a computing device, a transcript and text macros into vector representations. A word by word report may be predicted based upon, at least in part, the encoding. An attention mechanism may be queried based upon, at least in part, a decoder state. An attention distribution may be produced over an encoder output. An interpolation of the encoder output may be produced based upon, at least in part, the attention distribution. The interpolation of the encoder output may be input into a decoder for report modeling that includes text macro location and content.

Abstract: A method, computer program product, and computing system for: receiving an initial portion of an encounter record; processing the initial portion of the encounter record to generate initial content for a medical report; receiving one or more additional portions of the encounter record; and processing the one or more additional portions of the encounter record to modify the medical report.

Abstract: A method, computer program product, and computer system for encoding, by a computing device, a transcript and text macros into vector representations. A word by word report may be predicted based upon, at least in part, the encoding. An attention mechanism may be queried based upon, at least in part, a decoder state. An attention distribution may be produced over an encoder output. An interpolation of the encoder output may be produced based upon, at least in part, the attention distribution. The interpolation of the encoder output may be input into a decoder for report modeling that includes text macro location and content.

Abstract: DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. We apply a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients. Measurements of ctDNA can be used to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic approach can be generally applied.

Abstract: Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.

Abstract: A radiator module is provided including: a first infrared radiator including a first radiator tube arranged in a radiator plane; and a second infrared radiator including a second radiator tube arranged in the radiator plane. A cladding tube is arranged between the first radiator tube and the second radiator tube. Each of the first radiator tube, the second radiator tube, and the cladding tube is provided with a reflective coating.

Abstract: Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.

Abstract: A method, computer program product, and computing system for: receiving an initial portion of an encounter record; processing the initial portion of the encounter record to generate initial content for a medical report; receiving one or more additional portions of the encounter record; and processing the one or more additional portions of the encounter record to modify the medical report.

Abstract: Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.

Abstract: A radiator module is provided including: a first infrared radiator including a first radiator tube arranged in a radiator plane; and a second infrared radiator including a second radiator tube arranged in the radiator plane. A cladding tube is arranged between the first radiator tube and the second radiator tube. Each of the first radiator tube, the second radiator tube, and the cladding tube is provided with a reflective coating.

Abstract: Known devices for heat treatment comprise a process space surrounded by a furnace lining made of quartz glass, a heating facility, and a reflector. In order to provide, on this basis, a device for heat treatment having a furnace lining that can be manufactured easily and in variable shapes and enables rapid heating and cooling of the material to be heated and short process times and is characterized by its long service life, the invention proposes that the furnace lining comprises multiple wall elements having a side facing the process space and a side facing away from the process space, and that at least one of the wall elements comprises multiple quartz glass tubes that are connected to each other by means of an SiO2-containing connecting mass.

Abstract: Provided herein are methods for the detection of genetic mutations associated with cancer, particularly in the KIT gene.

Abstract: Methods for efficient and high throughput emulsion-based nucleic amplification are provided. In some aspects, emulsion mixtures are provided that require extremely low input energy (e.g., the energy generated by pipetting) to form emulsions that are effective for nucleic acid amplification. Efficient formulations for breaking emulsions are likewise provided.

Abstract: A dosing cup having a longitudinal axis includes a base; an opening opposing the base, wherein the opening is circumscribed by a rim; and a sidewall extending from the base to the rim. The sidewall includes a first portion extending from the rim toward the base. The first portion has a projection with a dosing indicium. The projection is defined by a length extending axially along the sidewall and a width that is perpendicular to the length. The width of the projection is less than the length of the projection. The sidewall includes a second portion extending from the base toward the rim. The second portion has a recess. The projection of the first portion mates with the recess of the second portion. The first portion has a first translucency and the second portion has a second translucency, wherein the first translucency is different than the second translucency.