Abstract: Prefabricated self-supporting lead-lined wall panels for radiation protection of an enclosed space are disclosed. A unified rectangular frame of tubular channel members provides for the attachment of a lead sheet and an overlying shielded laminate on one side of the frame with the elongated slots or channels on the other side detachably supporting a trim panel. Both the channel openings and an exposed side of the frame provide points of attachment of the wall panels to existing structures or to another wall panel in edge-to-edge or perpendicular relationship. Also the channel openings of the frame provide conduit space for the installation of electrical wiring.