Patents by Inventor Frank E. Hagie

Frank E. Hagie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8686225
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: April 1, 2014
    Assignee: Ventria Bioscience Inc.
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
  • Publication number: 20120195883
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Application
    Filed: April 17, 2012
    Publication date: August 2, 2012
    Applicant: VENTRIA BIOSCIENCE
    Inventors: NING HUANG, RAYMOND L. RODRIQUEZ, FRANK E. HAGIE, DAVID M. STALKER
  • Patent number: 8158857
    Abstract: The invention is directed to monocot plant seed products comprising human serum albumin, and to methods of making said monocot plant seed products comprising human serum albumin and to therapeutic compositions comprising them.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 17, 2012
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
  • Publication number: 20100183589
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Application
    Filed: March 31, 2010
    Publication date: July 22, 2010
    Applicant: VENTRIA BIOSCIENCE
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie, David M. Stalker
  • Patent number: 7718851
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 18, 2010
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20100119691
    Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.
    Type: Application
    Filed: September 11, 2009
    Publication date: May 13, 2010
    Inventors: Ning HUANG, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20100031394
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Application
    Filed: November 27, 2007
    Publication date: February 4, 2010
    Inventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
  • Publication number: 20100003235
    Abstract: The present invention relates, generally, to oral formulations including one or more recombinantly-produced human milk proteins. The formulations of the present invention may be used to prevent the onset of diarrhea in patients who have been or will be exposed to one or more agents known to cause diarrhea, and to prevent the recurrence of diarrhea in a patient recovering therefrom. The formulations may also be used in the treatment of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The formulations may also be beneficially administered in accordance with methods for promoting the development of healthy intestinal flora in a human patient.
    Type: Application
    Filed: September 28, 2006
    Publication date: January 7, 2010
    Inventors: Frank E. Hagie, Delia Bethell, Ning Huang
  • Publication number: 20090258004
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Application
    Filed: November 27, 2007
    Publication date: October 15, 2009
    Inventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
  • Publication number: 20080318277
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Application
    Filed: April 21, 2008
    Publication date: December 25, 2008
    Applicant: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 7417178
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: August 26, 2008
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20080050503
    Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.
    Type: Application
    Filed: January 27, 2006
    Publication date: February 28, 2008
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Patent number: 7304208
    Abstract: A method of producing human serum albumin (HSA) in monocot plant seeds, by transforming a monocot plant cell with a chimeric gene containing a promoter from the gene of a maturation-specific monocot plant storage protein, a first DNA sequence operably linked to the promoter and encoding a signal sequence, and a second DNA sequence linked in translation frame with the first DNA sequence and encoding HSA, where the first DNA sequence and the second DNA sequence together encode a fusion protein containing an N-terminal signal sequence and the HSA; growing a monocot plant from the transformed monocot plant cell for a time sufficient to produce seeds containing the HSA; and harvesting the seeds from the plant.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: December 4, 2007
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
  • Patent number: 6991824
    Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: January 31, 2006
    Assignee: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20040111766
    Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
    Type: Application
    Filed: August 12, 2003
    Publication date: June 10, 2004
    Applicant: Ventria Bioscience
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20030221223
    Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
    Type: Application
    Filed: April 11, 2003
    Publication date: November 27, 2003
    Inventors: Ning Huang, Raymond L. Rodriquez, Frank E. Hagie, David M. Stalker
  • Publication number: 20030074700
    Abstract: The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a transgenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.
    Type: Application
    Filed: February 14, 2002
    Publication date: April 17, 2003
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie
  • Publication number: 20030056244
    Abstract: The invention is directed to improved animal feed compositions comprising one or more milk proteins produced in the seeds of a transgenic plant and methods of making and using the same.
    Type: Application
    Filed: February 14, 2002
    Publication date: March 20, 2003
    Inventors: Ning Huang, Raymond L. Rodriguez, Frank E. Hagie