Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: A method of providing a structural drop-off in a preplied two or more sheet resin impregnated laminate for forming a composite of several laminates having different structural drop-off positions, each of the sheets having unidirectional fibers oriented at a bias relative to the fibers of the other sheet, and the steps of the method including making a plurality of feather cuts along one edge of the sheets in the direction of the fibers of one sheet and across the direction of the fibers of the other sheet resulting in negligible structural effect on one sheet and foreshortening of the fibers in the other sheet thereby providing a structural drop-off internal to the edge of the preplied two sheet laminate.

Abstract: A continuous process for steam-refining crude fatty oils or crude degummed fatty oils to remove free fatty acids, odoriferous material, and color bodies and thereby to produce a fully deodorized, high stability, bland, finished oil. Following degumming, if needed, the crude fatty oil is pretreated with phosphoric (or citric) acid while excluding air and oxygen, to react trace metals and other contaminants and then the oil is treated with absorptive clay under specified conditions of moisture, vacuum, and temperature to remove the trace metals and most of the color bodies from the oil. The filtered oil is then steam refined, under specified conditions of steam sparging, vacuum and temperature, to remove free fatty acids, odoriferous material, and other volatile non-fatty oil material, and to destroy certain color bodies. The process may also include fractionating and recovering, as separate products, the fatty acids and other stream-distilled material contained in the crude fatty oils.