Abstract: The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or without IFN-? added, resulting in neuronal death, and simulated neurodegenerative diseases. The neurodegenerative disease is treated using a JAK/STAT pathway inhibitor, including (-)-epigallocatechin-3-gallate (EGCG), to modulate JAK1 or STAT1 phosphorylation, resulting in resistance to gp120 or Tat neurotoxicity. The invention may be used to treat neurons afflicted with HIV-associated Dementia, multiple sclerosis, Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, or Pick's Disease, and may act in conjunction with antiviral treatment, like HAART.

Abstract: The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or without IFN-? added, resulting in neuronal death, and simulated neurodegenerative diseases. The neurodegenerative disease is treated using a JAK/STAT pathway inhibitor, including (—)-epigallocatechin-3-gallate (EGCG), to modulate JAK1 or STAT1 phosphorylation, resulting in resistance to gp120 or Tat neurotoxicity. The invention may be used to treat neurons afflicted with HIV-associated Dementia, multiple sclerosis, Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, or Pick's Disease, and may act in conjunction with antiviral treatment, like HAART.

Abstract: A method for enhancing the nutritional value and the vitamin A content of bird food while simultaneously rendering the bird food undesirable to predators comprising a capsicum botanical.

Abstract: A selective call receiver (10) utilizes a method for performing over-the-air software programming when the selective call receiver (10) is on or switched off by a user. A first selective call signal is received and programming related information including an anticipated time of transmission of a second selective call signal is received. The selective call receiver (10) is prepared to receive the second selective call signal in response to the programming related information received, whereby the receiver circuitry (30) is energized at the anticipated time of transmission to receive the second selective call signal. The selective call receiver (10) is further switched on at the anticipated time of transmission of the second selective call signal, and the receiver circuitry (30) is energized to receive the second selective call signal when the user has switched off the selective call receiver (10) prior to the anticipated time.

Abstract: A selective call receiver receives a selective call signal (400) comprising a preamble signal (410). The selective call receiver comprises receiver circuitry (102) for receiving and demodulating the selective call signal (400). A preamble detector (105) is coupled to the receiver circuitry (102) for detecting the preamble signal (410), and a battery saver circuit (126) selectively activates and deactivates the receiver circuitry (102) in response to a signal from a processor (114). The processor (114) provides the signal to the battery saver circuit (126) to deactivate and activate the receiver circuitry (102) during reception of the preamble signal (410) in response to and subsequent to the preamble detector (105) detecting a portion of the preamble signal (410).

Abstract: A receiver (200) receives (203) a transmitted signal having a first predetermined signal for indicating a start of a new transmission to the receiver and having a second predetermined signal inserted at periodic sampling time intervals for synchronizing the receiver to the transmitted signal. The receiver (200) synchronizes to the transmitted signal by detecting the first predetermined signal (208) followed by the second predetermined signal (210), and establishing subsequent periodic sampling time intervals therefrom. The receiver (200) conserves power (228) during a second portion of a periodic sampling time interval following a detection of a first portion of the second predetermined signal (210) during a first portion of the periodic sampling time interval.