Abstract: Provided are methods for the treatment of disorders of the central nervous system (CNS) and the eye. In particular, use of compositions comprising a compound capable of modulating a target gene or gene product is described for the preparation of a pharmaceutical composition for the treatment of disorders of the CNS and/or the eye, wherein the composition is designed to be administered outside the blood-CNS and the blood-retina barriers. Furthermore, methods are provided for identifying and obtaining nucleic acid molecules encoding polypeptides involved in CNS disorders or of the eye, methods for diagnosing said disorders as well as transgenic animal deficient in the expression of target genes identified in accordance with the described method. In addition, methods of identifying and isolating drugs that are particularly useful for the treatment of disorders related to the CNS and/or the eye are disclosed.

Abstract: Provided are methods for the treatment of disorders of the central nervous system (CNS) and the eye. In particular, use of compositions comprising a compound capable of modulating a target gene or gene product is described for the preparation of a pharmaceutical composition for the treatment of disorders of the CNS and/or the eye, wherein the composition is designed to be administered outside the blood-CNS and the blood-retina barriers. Furthermore, methods are provided for identifying and obtaining nucleic acid molecules encoding polypeptides involved in CNS disorders or of the eye, methods for diagnosing said disorders as well as transgenic animal deficient in the expression of target genes identified in accordance with the described method. In addition, methods of identifying and isolating drugs that are particularly useful for the treatment of disorders related to the CNS and/or the eye are disclosed.

Abstract: In electronic systems for power adjustment in motor vehicles, conventional mechanical linkages or Bowden cables are replaced or supplemented by the transmission of electric signals. Such an electronic power adjustment device contains a control unit (6) which acts on the power adjustor (9) via an electric actuator (8). In order to influence the engine power, an accelerator pedal (5) is provided as a setpoint generator. In a converter (7), the accelerator pedal position is converted into an electric signal which is supplied to the control unit (6). During the starting of the vehicle, a driving authorization control is carried out. The vehicle engine can already be started during the driving authorization control, but accelerator pedal position is taken into account by the control unit (6) only when the driving authorization control is concluded positively. This ensures both a reliable control of driving authorization and comfortable and reliable starting of the vehicle engine by an authorized driver.

Abstract: A gas-pedal module has a gas pedal (12) which is mounted pivotably in a housing and can be actuated, counter to a restoring spring, with pedal-force-dependent hysteresis, a pedal-position sensor producing an electric signal corresponding to the pedal position. In view of the high pedal forces, precise and expensive bearings are necessary in order to avoid jamming of the gas pedal (12). In order to reduce the production costs arid nevertheless reliably to prevent jamming, it is proposed to mount the gas pedal (12) in a floating manner in a bearing element (28) which has play in the upward direction. Specific selection of the coefficient of friction on the contact surface (30) between the bearing journal (18) and the bearing element (28) makes it possible to achieve a hysteresis as is desired in the case of such gas-pedal modules.

Abstract: A slip-controlled brake system, especially for use with automotive vehicles has a brake pressure generator (1) accommodating a master cylinder (2) connected to the brake pressure generator through master brake conduits (62,63) are the wheel brakes (31 to 34), comprising hydraulic auxiliary pressure pumps (21,26) and wheel sensors (S1 to S4) and electronic circuits capable to control, for slip control purposed, electromagnetically actuable pressure fluid inlet valves (24,25,29,30) and pressure fluid outlet valves (22,23,35,36) provided in the pressure fluid conduits, with pressure pulsation attenuators (27) of a defined volume expansion and flow length being provided for noise reduction purposed during the control operation, between the master cylinder (2) and the wheel brakes (31 through 34).

Abstract: A slip-controlled brake system, especially for use with automotive vehicles has a brake pressure generator (1) accommodating a master cylinder (2) connected to the brake pressure generator through master brake conduits (62,63) are the wheel brakes (31 to 34), comprising hydraulic auxiliary pressure pumps (21,26) and wheel sensors (S1 to S4) and electronic circuits capable to control, for slip control purposed, electromagnetically actuable pressure fluid inlet valves (24,25,29,30) and pressure fluid outlet valves (22,23,35,36) provided in the pressure fluid conduits, with pressure pulsation attenuators (27) of a defined volume expansion and flow length being provided for noise reduction purposed during the control operation, between the master cylinder (2) and the wheel brakes (31 through 34).