Abstract: A tire includes a pair of sidewalls extending from a respective bead area to a tread. The tread is formed with a plurality of tread elements and a radially outer surface. A sensor unit is mounted to the tire and includes a pair of electrical contacts. The tread wear sensor plug includes a cylindrical projection extending through an opening formed in one of the tread elements, a flange, and a wire including proximal ends disposed in the flange and a distal end near a radially outer surface of the projection. An electrical circuit is formed by each proximal end of the wire electrically contacting a respective one of the sensor unit electrical contacts. When the tread element and the cylindrical projection wear down to the distal end of the wire, the wire and the circuit break. A notice is transmitted by the sensor unit when the circuit breaks.

Abstract: A tire includes a pair of sidewalls extending from a respective bead area to a tread. The tread is formed with a plurality of tread elements and a radially outer surface. A sensor unit is mounted to the tire and includes a pair of electrical contacts. The tread wear sensor plug includes a cylindrical projection extending through an opening formed in one of the tread elements, a flange, and a wire including proximal ends disposed in the flange and a distal end near a radially outer surface of the projection. An electrical circuit is formed by each proximal end of the wire electrically contacting a respective one of the sensor unit electrical contacts. When the tread element and the cylindrical projection wear down to the distal end of the wire, the wire and the circuit break. A notice is transmitted by the sensor unit when the circuit breaks.

Abstract: A tire includes a pair of sidewalls extending from a respective bead area to a tread. The tread is formed with a plurality of tread elements and a radially outer surface, and a chamber is formed in one of the tread elements. A sensor unit is mounted to the tire and includes a pair of electrical contacts. The polymer plug includes a wire disposed in the chamber. The wire includes proximal ends and a distal end near a radially outer surface of the tread. A liquid polymer is injected into the chamber and cured. An electrical circuit is formed by each proximal end of the wire electrically contacts a respective one of the sensor unit electrical contacts. When the tread element wears down to the distal end of the wire, the wire and the circuit break. A notice is transmitted by the sensor unit when the circuit breaks.

Abstract: The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.

Abstract: The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.

Abstract: An off-road vehicle includes a body having at least one fender positioned over at least one wheel or track of the off-road vehicle. The at least one wheel or track is configured to engage a ground surface. The off-road vehicle also includes at least one spatial locating antenna positioned beneath the at least one fender. A top side of the at least one fender is positioned above the at least one spatial locating antenna relative to the ground surface, and the top side extends beyond a lateral extent and a longitudinal extent of the at least one spatial locating antenna.

Abstract: The present application relates generally to a method for vision correction using corneal collagen crosslinking (“CCXL”), in which the physician is able to precisely control the pattern of ultraviolet (“UV”) energy delivered to the cornea, by means of a programmable masking array placed between the UV source and the cornea. A CCXL LCD masked is used to create various patterns of “on” and “off” pixels. The physician is able to control the degree of polarization of the LCD pixels, thereby allowing the physician to create various patterns of UV irradiation and thus, varying levels of CCXL.

Abstract: A fundus camera for photographing a fundus of an eye that includes a plurality of light sources with differing frequencies for illuminating the fundus, a plurality of fixation lights configured to orient the fundus in varying positions, and an imaging sensor. The fundus camera further includes at least one processor configured to cause the illumination of the plurality of light sources and the plurality of fixation lights in a predetermined pattern to obtain a plurality of narrow bandwidth images of the fundus and to manipulate and stitch the resulting narrow bandwidth images into a composite color image.

Abstract: A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea.

Abstract: An off-road vehicle includes a body having at least one fender positioned over at least one wheel or track of the off-road vehicle. The at least one wheel or track is configured to engage a ground surface. The off-road vehicle also includes at least one spatial locating antenna positioned beneath the at least one fender. A top side of the at least one fender is positioned above the at least one spatial locating antenna relative to the ground surface, and the top side extends beyond a lateral extent and a longitudinal extent of the at least one spatial locating antenna.

Abstract: A fundus camera for photographing a fundus of an eye that includes a plurality of light sources with differing frequencies for illuminating the fundus, a plurality of fixation lights configured to orient the fundus in varying positions, and an imaging sensor. The fundus camera further includes at least one processor configured to cause the illumination of the plurality of light sources and the plurality of fixation lights in a predetermined pattern to obtain a plurality of narrow bandwidth images of the fundus and to manipulate and stitch the resulting narrow bandwidth images into a composite color image.

Abstract: An off-road vehicle includes a body having at least one fender positioned over at least one wheel or track of the off-road vehicle. The at least one wheel or track is configured to engage a ground surface. The off-road vehicle also includes at least one spatial locating antenna positioned beneath the at least one fender. A top side of the at least one fender is positioned above the at least one spatial locating antenna relative to the ground surface, and the top side extends beyond a lateral extent and a longitudinal extent of the at least one spatial locating antenna.

Abstract: A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea.

Abstract: An air maintenance tire pump simulator that simulates the environment of an air maintenance tire system is provided. The simulator includes at least one pneumatic cylinder, a structure that forms a closed cavity, and a pneumatic conduit extending between and fluidly connecting the pneumatic cylinder and the closed cavity. A cam is operably connected to a motor, and is also operably connected to the pneumatic cylinder. Engagement of the motor actuates rotation of the cam, which in turn actuates operation of the pneumatic cylinder to increase a pressure in the closed cavity. A method of simulating an air maintenance tire system is also provided.

Abstract: A device and method for applying light to the cornea of the eye as, for example, to promote crosslinking of collagen in the cornea for vision correction. The device may include a structure having form and size similar to a conventional contact lens. The structure may include an optically dispersive element such as a mass of an optically dispersive material that may be contained in a cavity of a reflective element. Light applied to the dispersive mass as, for example, by an optical fiber connected to the structure is dispersed in the structure and passes into the cornea. The patient may blink or close the eye during the procedure, which increases patient comfort and aids in maintaining hydration of the cornea.

Abstract: The present application relates generally to a method for vision correction using corneal collagen crosslinking (“CCXL”), in which the physician is able to precisely control the pattern of ultraviolet (“UV”) energy delivered to the cornea, by means of a programmable masking array placed between the UV source and the cornea. A CCXL LCD masked is used to create various patterns of “on” and “off” pixels. The physician is able to control the degree of polarization of the LCD pixels, thereby allowing the physician to create various patterns of UV irradiation and thus, varying levels of CCXL.

Abstract: An off-road vehicle includes a body having at least one fender positioned over at least one wheel or track of the off-road vehicle. The at least one wheel or track is configured to engage a ground surface. The off-road vehicle also includes at least one spatial locating antenna positioned beneath the at least one fender. A top side of the at least one fender is positioned above the at least one spatial locating antenna relative to the ground surface, and the top side extends beyond a lateral extent and a longitudinal extent of the at least one spatial locating antenna.

Abstract: An air maintenance tire pump simulator that simulates the environment of an air maintenance tire system is provided. The simulator includes at least one pneumatic cylinder, a structure that forms a closed cavity, and a pneumatic conduit extending between and fluidly connecting the pneumatic cylinder and the closed cavity. A cam is operably connected to a motor, and is also operably connected to the pneumatic cylinder. Engagement of the motor actuates rotation of the cam, which in turn actuates operation of the pneumatic cylinder to increase a pressure in the closed cavity. A method of simulating an air maintenance tire system is also provided.

Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.

Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.