Patents by Inventor Frank Gonzalez
Frank Gonzalez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11555818Abstract: The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.Type: GrantFiled: May 14, 2019Date of Patent: January 17, 2023Assignee: The USA, as represted by the Secretary, Dept. of and Human Services, National Institutes of HealthInventors: Majda Haznadar, Ewy Mathe, Andrew D. Patterson, Curtis Craig Harris, Frank Gonzalez, Kristopher Krausz, Soumen Manna
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Publication number: 20210102121Abstract: The present disclosure is directed to etching compositions that are useful, e.g., for selectively removing tungsten (W) and/or titanium nitride (TiN) from a semiconductor substrate as an intermediate step in a multistep semiconductor manufacturing process.Type: ApplicationFiled: November 24, 2020Publication date: April 8, 2021Inventors: Tomonori Takahashi, Frank Gonzalez
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Patent number: 10961453Abstract: The present disclosure is directed to etching compositions that are useful, e.g., for selectively removing tungsten (W) and/or titanium nitride (TiN) from a semiconductor substrate as an intermediate step in a multistep semiconductor manufacturing process.Type: GrantFiled: August 15, 2019Date of Patent: March 30, 2021Assignee: Fujifilm Electronic Materials U.S.A., Inc.Inventors: Tomonori Takahashi, Frank Gonzalez
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Publication number: 20200079998Abstract: The present disclosure is directed to etching compositions that are useful, e.g., for selectively removing tungsten (W) and/or titanium nitride (TiN) from a semiconductor substrate as an intermediate step in a multistep semiconductor manufacturing process.Type: ApplicationFiled: August 15, 2019Publication date: March 12, 2020Inventors: Tomonori Takahashi, Frank Gonzalez
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Publication number: 20190369102Abstract: The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.Type: ApplicationFiled: May 14, 2019Publication date: December 5, 2019Inventors: Majda HAZNADAR, Ewy MATHE, Andrew D. PATTERSON, Curtis Craig HARRIS, Frank GONZALEZ, Kristopher KRAUSZ, Soumen MANNA
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Patent number: 10393745Abstract: The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.Type: GrantFiled: July 11, 2014Date of Patent: August 27, 2019Assignee: The USA, as represented by the Secretary, Department of Heath and Human ServicesInventors: Majda Haznadar, Ewy Mathe, Andrew D. Patterson, Curtis Craig Harris, Frank Gonzalez, Kristopher Krausz, Soumen Manna
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Publication number: 20160169899Abstract: The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.Type: ApplicationFiled: July 11, 2014Publication date: June 16, 2016Inventors: Majda HAZNADAR, Ewy MATHE, Andrew D. PATTERSON, Curtis Craig HARRIS, Frank GONZALEZ, Kristopher KRAUSZ, Soumen MANN
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Publication number: 20100058485Abstract: An end to end content protection system that includes enhanced digital rights management (DRM). The system provides content delivery to devices over a managed multimedia home network. The system includes a domain manager for receiving content, wherein the domain manager includes a cable card, conditional access component and a MSO security application and a managed client device, coupled to and registered with the domain manager, the managed client device running a security DRM application client, the managed client device communicates with the MSO security application in the domain manager, wherein the MSO security application of the domain manager and the security DRM application client of the managed client instantiate a preferred DRM as an overlay on top of any other content protection scheme.Type: ApplicationFiled: August 26, 2009Publication date: March 4, 2010Inventor: Frank Gonzalez
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Publication number: 20070154971Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C19 levels in individuals relative to P450 2C19 levels in a control population.Type: ApplicationFiled: March 7, 2007Publication date: July 5, 2007Applicant: National Institutes of HealthInventors: Harry Gelboin, Kristopher Krausz, Frank Gonzalez
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Patent number: 7147798Abstract: The present invention provides an aluminum etchant solution for etching an aluminum surface in the presence of solder bumps. The etchant solution includes about 42% to about 80% phosphoric acid; about 0.1% to about 6% nitric acid; about 5% to about 40% acetic acid; about 0.005% to about 5% of an amine oxide surfactant; about 0.1% to about 8% of a Pb solubilizing additive; and about 5 to about 25% de-ionized water; wherein the solder bumps are substantially phosphate free after the etching. Also provided is a process for etching an exposed aluminum surface in a semiconductor structure in the presence of solder bumps including the steps of: contacting the exposed aluminum surface with the etchant solution; rinsing the semiconductor structure with de-ionized water; and drying the semiconductor structure to remove residual water; wherein the solder bumps are substantially phosphate free after the etching.Type: GrantFiled: August 19, 2004Date of Patent: December 12, 2006Assignee: Arch Specialty Chemicals, Inc.Inventors: Frank Gonzalez, Emil Kneer, Michelle Elderkin, Vince Leon
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Publication number: 20050266695Abstract: The present invention provides an aluminum etchant solution for etching an aluminum surface in the presence of solder bumps. The etchant solution includes about 42% to about 80% phosphoric acid; about 0.1% to about 6% nitric acid; about 5% to about 40% acetic acid; about 0.005% to about 5% of an amine oxide surfactant; about 0.1% to about 8% of a Pb solubilizing additive; and about 5 to about 25% de-ionized water; wherein the solder bumps are substantially phosphate free after the etching. Also provided is a process for etching an exposed aluminum surface in a semiconductor structure in the presence of solder bumps including the steps of: contacting the exposed aluminum surface with the etchant solution; rinsing the semiconductor structure with de-ionized water; and drying the semiconductor structure to remove residual water; wherein the solder bumps are substantially phosphate free after the etching.Type: ApplicationFiled: July 1, 2005Publication date: December 1, 2005Applicant: Arch Specialty Chemicals, Inc.Inventors: Frank Gonzalez, Emil Kneer, Michelle Elderkin, Vince Leon
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Publication number: 20050136433Abstract: The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.Type: ApplicationFiled: August 3, 2004Publication date: June 23, 2005Inventors: Frank Gonzalez, Pedro Fernandez-Salguero
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Publication number: 20050075487Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C family members, and in methods of screening individuals for a poor metabolizing individual human P450 2C family phenotypes.Type: ApplicationFiled: July 9, 2003Publication date: April 7, 2005Applicant: Health and Human Services, Department of United States of AmericaInventors: Harry Gelboin, Kristopher Krausz, Frank Gonzalez
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Publication number: 20050054009Abstract: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C19 levels in individuals relative to P450 2C19 levels in a control population.Type: ApplicationFiled: September 14, 2004Publication date: March 10, 2005Applicant: National Institutes of HealthInventors: Harry Gelboin, Kristopher Krausz, Frank Gonzalez
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Publication number: 20050040139Abstract: The present invention provides an aluminum etchant solution for etching an aluminum surface in the presence of solder bumps. The etchant solution includes about 42% to about 80% phosphoric acid; about 0.1% to about 6% nitric acid; about 5% to about 40% acetic acid; about 0.005% to about 5% of an amine oxide surfactant; about 0.1% to about 8% of a Pb solubilizing additive; and about 5 to about 25% de-ionized water; wherein the solder bumps are substantially phosphate free after the etching. Also provided is a process for etching an exposed aluminum surface in a semiconductor structure in the presence of solder bumps including the steps of: contacting the exposed aluminum surface with the etchant solution; rinsing the semiconductor structure with de-ionized water; and drying the semiconductor structure to remove residual water; wherein the solder bumps are substantially phosphate free after the etching.Type: ApplicationFiled: August 19, 2004Publication date: February 24, 2005Inventors: Frank Gonzalez, Emil Kneer, Michelle Elderkin, Vince Leon
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Patent number: 5851221Abstract: An implantable medical device of the type formed of a hermetically sealed enclosure attached on a enclosure attachment surface thereof to a module attachment surface of a pre-formed header module is disclosed. The pre-formed header module is attached to the enclosure attachment surface through use of a retention structure extending away from the enclosure surface into proximity with a portion of the pre-formed header module when the enclosure and module attachment surfaces are aligned with respect to one another. The retention structure comprises a bendable member that is bent from an initial position allowing the pre-formed header module to be seated with respect to the hermetically sealed enclosure to a retention position making an attachment against a bend engaging portion of the pre-formed header module.Type: GrantFiled: August 1, 1997Date of Patent: December 22, 1998Assignee: Medtronic Inc.Inventors: Eric M. Rieder, Frank Gonzalez, Randal C. Schulhauser, Bryan Zart
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Patent number: 5433756Abstract: Catalytic clean-combustion-promoter compositions for use with finished gasoline or diesel fuels in compression ignition engines and spark ignition engines improve fuel efficiency and reduce air polluting emissions. The compositions utilize ketones as solvents, alcohols as cosolvents, nitroparaffin compounds as combustion supporters, and, to promote the chemical reactions, a catalytic medium is used. When the additive compositions are employed in microvolumetric concentrations ranging from 670 to 1,350 parts per million by volume of engine fuel, the chemical bonding of the carbon molecules with the oxygen molecules is increased during the combustion process, thus, producing a synergistic effect, which increases the combustion characteristic of the fuels to be burned and reduces the tendency of the fuel to create deposits, and therefore reduces the CO.sub.2 and NO.sub.X emissions, and increases the fuel economy.Type: GrantFiled: February 22, 1994Date of Patent: July 18, 1995Inventor: Frank Gonzalez
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Patent number: 5316558Abstract: Petroleum derived fuel compositions of improved efficiency for use with finished gasoline and diesel fuels in compression ignition engines and spark ignition engines include a catalytic clean-combustion-promoter composition to improve fuel efficiency and reduce their air polluting effects. The catalytic clean-combustion-promoter compositions utilize ketones as solvents, alcohols as cosolvents, ethers as octane supporters, nitroparaffin compounds as combustion supporters, and, to promote the chemical reactions a catalytic medium is used in combination with aromatic amines. When all the compounds are combined in the recited quantities, the molecular structure and surface tension of the fuel is transformed through chemical bonding to produce a synergistic effect, which increases the combustion characteristic of the fuels to be burned and reduces the tendency of the fuel to create deposits, and therefore reduces the exhaust emissions.Type: GrantFiled: August 19, 1992Date of Patent: May 31, 1994Inventor: Frank Gonzalez
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Patent number: 5141524Abstract: The incorporation of these catalytic clean combustion promoters compositions to liquid fuels for internal combustion engines, improve their combustion properties; thus, reducing their air polluting emissions as nitrogen oxides (NO.sub.x), carbon monoxide (CO), and unburned hydrocarbons (HC). Also, these fuel activators reduce smoke and particulate matter exhaust emissions. Moreover, the addition of these fuel activators, reduce the corrosion properties of fuels, clean the whole fuel systems of gums and varnishes, clean and prevent carbon deposits on injectors, valves and on the combustion chamber parts.The composition of these catalytic clean combustion promoters additives includes aromatic and aliphatic hydrocarbon solvents with and without oxygenated functional groups, aromatic amines, a catalytic agent in chemical reactions, nitroparaffin solvents, aliphatic ether as an octaine assistant, and/or Kerosene as a cetane assistant.Type: GrantFiled: November 2, 1990Date of Patent: August 25, 1992Inventor: Frank Gonzalez