Patents by Inventor Frank Graham
Frank Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11573256Abstract: A method and circuit for detecting a fault in a power transformer having an conductive shield layer sandwiched between electrical insulating layers separating the conductive shield layer from a first conductor and a second conductor, the second conductor opposite the conductive shield layer from the first conductor, and including, sensing a voltage energizing the shield layer, comparing the sensed voltage to a threshold voltage value corresponding to a fault, and upon satisfaction of the comparison, providing a fault indication when the comparison indicates the presence of a fault.Type: GrantFiled: December 16, 2019Date of Patent: February 7, 2023Assignee: GE Aviation Systems LimitedInventors: Peter James Handy, Benjamin Robert Daffurn, Frank Graham Osborne, Michael James Smith
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Publication number: 20200191852Abstract: A method and circuit for detecting a fault in a power transformer having an conductive shield layer sandwiched between electrical insulating layers separating the conductive shield layer from a first conductor and a second conductor, the second conductor opposite the conductive shield layer from the first conductor, and including, sensing a voltage energizing the shield layer, comparing the sensed voltage to a threshold voltage value corresponding to a fault, and upon satisfaction of the comparison, providing a fault indication when the comparison indicates the presence of a fault.Type: ApplicationFiled: December 16, 2019Publication date: June 18, 2020Inventors: Peter James Handy, Benjamin Robert Daffurn, Frank Graham Osborne, Michael James Smith
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Patent number: 10035009Abstract: A method of treating pancreatic cancer includes: inserting a device into a stomach or a duodenum; securing at least a portion of the device in position relative to the stomach or the duodenum; and delivering ultrasonic energy from the device to treat a target site in a pancreas.Type: GrantFiled: April 15, 2014Date of Patent: July 31, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Frank Graham Sommer, Chris J. Diederich
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Publication number: 20150018725Abstract: A method of treating pancreatic cancer includes: inserting a device into a stomach or a duodenum; securing at least a portion of the device in position relative to the stomach or the duodenum; and delivering ultrasonic energy from the device to treat a target site in a pancreas.Type: ApplicationFiled: April 15, 2014Publication date: January 15, 2015Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Frank Graham Sommer
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Patent number: 7704606Abstract: A method for repairing a basecoat/clearcoat finish or coating comprised of a fluorinated organosilane topcoat. A fluorinated urethane additive is added to the fluorinated organosilane topcoat composition to improve recoat adhesion with the repair basecoat.Type: GrantFiled: February 4, 2008Date of Patent: April 27, 2010Assignee: E. I. du Pont de Nemours and CompanyInventors: William Frank Graham, Douglas Robert Anton, Jeffery W. Johnson, Michael Joseph Michalczyk, Sape Kwesi Quashie
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Publication number: 20070128165Abstract: In the present invention, viruses, plasmids or both are constructed which contain viral DNA and lox sites positioned such that site-specific recombination between lox sites in separate plasmids results in generation of infectious viral DNA at high-efficiency in cotransfected host cells that have been engineered to express the Cre recombinase. Because of the high-efficiency and specificity of the Cre enzyme, suitably engineered plasmids can be readily recombined to produce infectious virus at high-efficiency in cotransfected 293 cells, without, at the same time, producing wild-type adenovirus, with the attendant problems for removal thereof. Use of recombinases besides Cre and recombinase recognition sites besides lox sites, and use of cells other than 293 cells are also disclosed and enabled, as are kits incorporating the site-specific vector system.Type: ApplicationFiled: November 6, 2006Publication date: June 7, 2007Inventors: Frank Graham, Robin Parks, Philip Ng
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Publication number: 20070014769Abstract: The present invention relates to methods for efficient and reliable construction of adenovirus vectors which contain and express foreign DNA and are useful for gene transfer into mammalian cells, for vaccines and for gene therapy. The invention provides for the growth and purification of adenovirus vectors (helper dependent vectors or HDVs) from which all or most of the viral genes have been removed. The vector system described herein is a new method designed to eliminate helper viruses from the final HDV preparation by cleavage of the helper virus DNA with an endonuclease, alone or in combination with other methods known to limit the level of helper virus contamination of helper dependent vector preparations. The disclosed methods and compositions also provide for regulated control of gene expression.Type: ApplicationFiled: September 25, 2006Publication date: January 18, 2007Inventors: Frank Graham, Silvia Bacchetti, Philip Ng, Robin Parks, Mauro Anglana
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Publication number: 20060110798Abstract: Embodiments of the invention provide cells that stably express an integrase family recombinase, for example Cre or FLP. Examples of production of such cells, and uses of such cells, are provided. In some embodiments, a cell may additionally express one or more adenovirus E1 proteins. In some embodiments, the cell is an in vitro human cell.Type: ApplicationFiled: December 30, 2005Publication date: May 25, 2006Inventor: Frank Graham
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Publication number: 20060063259Abstract: Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent adenoviruses (RCA). In certain embodiments are disclosed early region 1 (E1) deficient recombinant adenoviral vectors and complementing E1 positive host cells whose sequences are designed to avoid formation of RCA by homologous recombination between sequences in the vector and E1 sequences in the cells. One aspect of the invention involves the inversion of the packaging signal in a recombinant adenoviral vector relative to an adjacent or nearby inverted terminal repeat (ITR). Methods include use of site-specific intregrase family recombinases such as Cre or FLP and recombinase recognition sites such as lox sites or frt sites.Type: ApplicationFiled: September 21, 2004Publication date: March 23, 2006Inventor: Frank Graham
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Publication number: 20030118554Abstract: This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase target sites that are useful in reducing the level of contamination of helper virus in helper-dependent adenovirus vector preparations.Type: ApplicationFiled: July 26, 2002Publication date: June 26, 2003Inventors: Frank Graham, Michael A. Rudnicki, Martina Anton
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Patent number: 6385299Abstract: A centralized test apparatus is provided for a telecommunications network which includes local switches and a core network. Each local switch is connected through terminating lines to terminating equipment such as telephone handsets. The test apparatus enables a field engineer to obtain the identity of a terminating line from one of the local switches. When a field engineer dials the number of the test apparatus, the test apparatus retrieves the calling line identity on answering the call. It then transmits the calling line identity in speech form back to the calling line. After transmitting the calling line identity, the test apparatus offers a menu of further services which comprise a ring back service and the provision of a test tone on a specified telephone line.Type: GrantFiled: July 7, 2000Date of Patent: May 7, 2002Assignee: British Telecommunications public limited companyInventors: Alvin Brooks, Frank Graham Ward, Stephen F Lee
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Patent number: 6169783Abstract: A centralized test apparatus is provided for a telecommunications network which includes local switches and a core network. Each local switch is connected through terminating lines to terminating equipment such as telephone handsets. The test apparatus enables a field engineer to obtain the identity of a terminating line from one of the local switches. When a field engineer dials the number of the test apparatus, the test apparatus retrieves the calling line identity on answering the call. It then transmits the calling line identity in speech form back to the calling line. After transmitting the calling line identity, the test apparatus offers a menu of further services which comprise a ring back service and the provision of a test tone on a specified telephone line.Type: GrantFiled: March 10, 1998Date of Patent: January 2, 2001Assignee: British Telecommunicaitons public limited companyInventors: Alvin Brooks, Frank Graham Ward, Stephen F Lee
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Patent number: 6083284Abstract: A method and apparatus for treating a load with dyeliquor includes a pump/motor set, a dyeliquor circulating system holding the load and directing all the dyeliquor pumped by the pump to flow through the load, a motor current measurement device to measure current consumed by the electric motor while driving the pump, and a throttle valve adjusted to create a flowrate of the dyeliquor through the dyeliquor circulating system based on the current measured by the motor current measurement device. The flowrate of the dyeliquor increases linearly in proportion with increases in the current consumed by said electric motor while driving said pump. The apparatus also has a low system resistance to fluid flow allowing variations in a load resistance of the load to fluid flow to produce corresponding variations in the current of the electric motor measurable by the motor current measurement device.Type: GrantFiled: May 29, 1998Date of Patent: July 4, 2000Assignee: Falmer Investments, Ltd.Inventors: Frank Graham Clifford, William Tsui
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Patent number: 5948851Abstract: A coating composition that forms a finish that is soil resistant and easily cleaned having a binder of(A) an acrylic polymer of polymerized hydroxyl containing monomers of hydroxy alkyl (meth)acrylate having 1-4 carbon atoms in the alkyl group, and polymerized monomers from the group of alkyl (meth)acrylates having 1-18 carbon atoms in the alkyl group, styrene or any mixtures of the above and the acrylic polymer having a weight average molecular weight of about 2,000-20,000 determined by gel permeation chromatography,(B) an acrylic polymeric additive of polymerized monomers from the group of alkyl (meth)acrylates having 1-18 carbon atoms in the alkyl groups, styrene or any mixtures of the above, and polymerized fluoro alkyl containing monomer represented by the formula ##STR1## where R is selected from the group of hydrogen or an alkyl group having 1-2 carbon atoms, X is a divalent radical and R.sub.Type: GrantFiled: November 21, 1997Date of Patent: September 7, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: Douglas Robert Anton, Michael J. Darmon, William Frank Graham, Richard Ronald Thomas
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Patent number: 5914384Abstract: A coating composition that forms a finish that is soil resistant and easily cleaned having a binder of(A) an acrylic polymer of polymerized hydroxyl containing monomers of hydroxy alkyl (meth)acrylates having 1-4 carbon atoms in the alkyl groups and polymerized monomers from the group of alkyl (meth)acrylates having 1-18 carbon atoms in the alkyl groups, styrene or any mixtures of the above and the acrylic polymer has a weight average molecular weight of about 2,000-20,000 determined by gel permeation chromatography,(B) an acrylic polymeric additive of polymerized hydroxyl containing monomers of hydroxy alkyl (meth)acrylates having 1-4 carbon atoms in the alkyl groups, polymerized monomers from the group of alkyl (meth)acrylates having 1-18 carbon atoms in the alkyl groups, styrene or any mixtures of the above and polymerized fluoro alkyl containing monomer represented by the formula ##STR1## where R is selected from the group of hydrogen or an alkyl group having 1-2 carbon atoms, X is a divalent radical andType: GrantFiled: November 21, 1997Date of Patent: June 22, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: Douglas Robert Anton, Michael J. Darmon, William Frank Graham, Richard Ronald Thomas
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Patent number: 5705276Abstract: A coating composition containing about 45-80% by weight of a binder and 20-55% by weight of an organic liquid; wherein the binder contains(A) about 40-90% by weight, based on the weight of the binder, of an acrylic polymer containing polymerized hydroxyl containing monomers of the following group of hydroxy alkyl acrylate or methacrylates having 1-4 carbon atoms in the alkyl group, and polymerized alkyl acrylates and methacrylates having 1-18 carbon atoms in the alkyl groups, or styrene or any mixtures of the above and 0.1-5.0% by weight, based on the weight of the acrylic polymer, of polymerized fluoroalkyl containing monomer represented by the formula ##STR1## where R is hydrogen or an alkyl group having 1-2 carbon atoms, n is an integer of 1-11 and R.sub.f is a fluoroalkyl containing group having at least 4 carbon atoms and(B) about 10-60% by weight, based on the weight of the binder, of a fluorinated organic polyisocyanate crosslinking agent.Type: GrantFiled: October 28, 1996Date of Patent: January 6, 1998Assignee: E. I. Du Pont de Nemours and CompanyInventors: Douglas Robert Anton, Michael J. Darmon, William Frank Graham, Richard Ronald Thomas