Patents by Inventor Frank Grosveld

Frank Grosveld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies binding CTLA-4 and uses thereof
    Patent number: 12240905
    Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: March 4, 2025
    Assignee: Harbour BioMed (Shanghai) Co., Ltd.
    Inventors: Xin Gan, Yun He, Yuqiang Shen, Jiuqiao Zhao, Yiping Rong, Frank Grosveld, Dubravka Drabek, Marinus (Rien) Van Haperen, Rick Janssens
  • ANTIBODIES BINDING CTLA-4 AND USES THEREOF
    Publication number: 20220002414
    Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 6, 2022
    Applicant: Harbour BioMed (Shanghai) Co., Ltd.
    Inventors: Xin GAN, Yun HE, Yuqiang SHEN, Jiuqiao ZHAO, Yiping RONG, Frank Grosveld, Dubravka Drabek, Marinus (Rien) Van Haperen, Rick Janssens
  • Antibodies binding CTLA-4 and uses thereof
    Patent number: 11098122
    Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 24, 2021
    Assignee: HARBOUR BIOMED (SHANGHAI) CO., LTD.
    Inventors: Xin Gan, Yun He, Yuqiang Shen, Jiuqiao Zhao, Yiping Rong, Frank Grosveld, Dubravka Drabek, Marinus (Rien) Van Haperen, Rick Janssens
  • Method for analysing the interaction of nucleotide sequences in a three-dimensional DNA structure
    Patent number: 10934575
    Abstract: The present invention provides a method for analysing the interaction of one or more nucleotide sequence(s) from one or more region(s) of interest with other nucleotides sequences in a three-dimensional DNA structure, comprising the steps of: (a) providing a sample of crosslinked DNA; (b) digesting the cross-linked DNA with a first restriction enzyme; (c) ligating the cross-linked nucleotide sequences; (d) reversing the cross-linking; e) fragmenting the ligation and ligated molecules from (d); (f) hybridising the fragments from (e) to one or more oligonucleotides representing the sequences which are adjacent to the cleavage site of the first restriction enzyme in order to enrich for the ends of the nucleotide sequences that have been ligated to another nucleotide sequence in step (c); and (g) analysing the nucleotide sequence of the enriched fragments in order to identify the nucleotide sequences involved in interaction(s).
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: March 2, 2021
    Assignee: Erasmus Universiteit Medisch Centrum Rotterdam
    Inventors: Frank Grosveld, Tobias Knoch
  • ANTI-CD47 ANTIBODIES AND METHODS OF USE
    Publication number: 20200291114
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Application
    Filed: January 16, 2020
    Publication date: September 17, 2020
    Inventors: Frank GROSVELD, Scott CHAPPEL, Jonathan HILL, Pamela M. HOLLAND, Andrew LAKE, Alison PATERSON
  • Anti-CD47 antibodies and methods of use
    Patent number: 10570201
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: February 25, 2020
    Assignees: Erasmus University Medical Center, Surface Oncology, Inc.
    Inventors: Frank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
  • Anti-CD47 antibodies and methods of use
    Patent number: 10442858
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 15, 2019
    Assignees: Erasmus University Medical Center, Surface Oncology, Inc.
    Inventors: Frank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
  • ANTI-CD47 ANTIBODIES AND METHODS OF USE
    Publication number: 20180201677
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Application
    Filed: September 21, 2017
    Publication date: July 19, 2018
    Inventors: Frank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
  • ANTI-CD47 ANTIBODIES AND METHODS OF USE
    Publication number: 20180105591
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Application
    Filed: September 21, 2017
    Publication date: April 19, 2018
    Inventors: Frank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
  • Anti-CD47 antibodies and methods of use
    Patent number: 9803016
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: October 31, 2017
    Assignees: Erasmus University Medical Center, Surface Oncology, Inc.
    Inventors: Frank Grosveld, Scott Chappel, Jonathan Hill, Pamela M. Holland, Andrew Lake, Alison Paterson
  • ANTI-CD47 ANTIBODIES AND METHODS OF USE
    Publication number: 20170204181
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 20, 2017
    Inventor: Frank Grosveld
  • Anti-CD47 antibodies and methods of use
    Patent number: 9650441
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: May 16, 2017
    Assignees: Erasmus University Medical Center, Surface Oncology, Inc.
    Inventors: Frank Grosveld, Vito Palombella, Pamela M. Holland, Alison Paterson, Jonathan Hill
  • ANTI-CD47 ANTIBODIES AND METHODS OF USE
    Publication number: 20170081407
    Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.
    Type: Application
    Filed: September 21, 2016
    Publication date: March 23, 2017
    Inventors: Frank Grosveld, Vito Palombella, Pamela M. Holland, Alison Paterson, Jonathan Hill
  • METHOD FOR ANALYSING THE INTERACTION OF NUCLEOTIDE SEQUENCES IN A THREE-DIMENSIONAL DNA STRUCTURE
    Publication number: 20160289738
    Abstract: The present invention provides a method for analysing the interaction of one or more nucleotide sequence(s) from one or more region(s) of interest with other nucleotides sequences in a three-dimensional DNA structure, comprising the steps of: (a) providing a sample of cross-linked DNA; (b) digesting the cross-linked DNA with a first restriction enzyme; (c) ligating the cross-linked nucleotide sequences; (d) reversing the cross-linking; e) fragmenting the ligation and ligated molecules from (d); (f) hybridising the fragments from (e) to one or more oligonucleotides representing the sequences which are adjacent to the cleavage site of the first restriction enzyme in order to enrich for the ends of the nucleotide sequences that have been ligated to another nucleotide sequence in step (c); and (g) analysing the nucleotide sequence of the enriched fragments in order to identify the nucleotide sequences involved in interaction(s).
    Type: Application
    Filed: November 18, 2014
    Publication date: October 6, 2016
    Inventors: Frank Grosveld, Tobias Knoch
  • IMMUNOGLOBULIN 1
    Publication number: 20140037616
    Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
    Type: Application
    Filed: July 26, 2013
    Publication date: February 6, 2014
    Applicant: Erasmus Universiteit Rotterdam
    Inventor: Frank Grosveld
  • Circular chromosome conformation capture (4C)
    Patent number: 8642295
    Abstract: The present invention relates in one aspect to a method for analyzing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (eg.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: February 4, 2014
    Assignee: Erasmus University Medical Center
    Inventors: Wouter De Laat, Frank Grosveld
  • Immunoglobulin 2
    Publication number: 20140033335
    Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
    Type: Application
    Filed: July 30, 2013
    Publication date: January 30, 2014
    Applicant: Erasmus Universiteit Rotterdam
    Inventor: Frank Grosveld
  • Method for the production of a single heavy chain antibody
    Patent number: 8507748
    Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: August 13, 2013
    Assignee: Erasmus Universiteit Rotterdam
    Inventor: Frank Grosveld
  • Method for the production of a single heavy chain antibody
    Patent number: 8502014
    Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: August 6, 2013
    Assignee: Erasmus Universiteit Rotterdam
    Inventor: Frank Grosveld
  • Capture and characterized co-localized chromatin (4C) technology
    Patent number: 8153373
    Abstract: The present invention relates in one aspect to a method for analyzing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (e.g.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: April 10, 2012
    Assignee: Erasmus University Medical Center
    Inventors: Wouter De Laat, Frank Grosveld