Patents by Inventor Frank H. Ebetino

Frank H. Ebetino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10660884
    Abstract: The present invention provides compositions and methods for providing controllable local delivery of a conjugate of chloroquine (CQ) and a bisphosphonate to treat diseases characterized by abnormal bone metabolism. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: May 26, 2020
    Assignee: University of Rochester
    Inventors: Robert Boeckman, Brendan Boyce, Lifeng Xiao, Zhenqiang Yao, Frank H. Ebetino
  • Publication number: 20190169214
    Abstract: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 6, 2019
    Inventors: Frank H. EBETINO, Shuting SUN, Mark W. LUNDY, Charles E. MCKENNA, Eric RICHARD, Parish SEDGHIZADEH, Keivan SADRERAFI, Philip T. CHERIAN
  • Publication number: 20180318282
    Abstract: The present invention provides compositions and methods for providing controllable local delivery of a conjugate of chloroquine (CQ) and a bisphosphonate to treat diseases characterized by abnormal bone metabolism. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.
    Type: Application
    Filed: November 2, 2016
    Publication date: November 8, 2018
    Inventors: Robert Boeckman, Brendan Boyce, Lifeng Xiao, Zhingqiang Yao, Frank H. Ebetino
  • Publication number: 20160310621
    Abstract: Described herein are single and dual modality bisphosphonate conjugated imaging probes. Also described herein are methods of synthesizing and using the single and dual modality bisphosphonate conjugated imaging probes.
    Type: Application
    Filed: April 20, 2016
    Publication date: October 27, 2016
    Inventors: Charles E. McKenna, Shuting Sun, Frank H. Ebetino, Mark W. Lundy, Zibo Li
  • Patent number: 5574024
    Abstract: The present invention involves novel methylene phosphonoalkylphosphinic acids, pharmaceutical compositions containing such compounds, and methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism by administering such compounds to a human or lower animal.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: November 12, 1996
    Inventor: Frank H. Ebetino
  • Patent number: 5519013
    Abstract: The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: May 21, 1996
    Assignee: The Procter & Gamble Company
    Inventors: Frank H. Ebetino, James J. Benedict
  • Patent number: 5393746
    Abstract: The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cylopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: February 28, 1995
    Assignee: P&G Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, Kent W. Buckingham, Jocelyn E. McOsker
  • Patent number: 5391743
    Abstract: The present invention relates to quaternary nitrogen-containing phosphonate compounds, and the pharmaceutically-acceptable salts and esters thereof and having the general structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.5 and R.sup.8 are defined in claim 1, m and n are integers from 0 to 10; m+n is from 0 to 10;Z is a saturated, unsaturated, or aromatic, monocyclic or polycyclic carbocycle or monocyclic or polycyclic heterocycle containing one or more heteroatoms selected from O, S, or N, wherein at least one heteroatom is a quaternary nitrogen atom;R is COOH; PO.sub.3 H.sub.2 ; SO.sub.3 H; or P(O)(OH)R.sub.4, wherein R.sub.4 is substituted or unsubstituted alkyl of 1-8 carbon atoms;The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: February 21, 1995
    Assignee: Procter & Gamble Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, Susan M. Kaas, Marion D. Francis, Dennis G. A. Nelson, John M. Janusz
  • Patent number: 5334586
    Abstract: The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: August 2, 1994
    Assignee: Procter & Gample Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, James J. Benedict
  • Patent number: 5137880
    Abstract: The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cylopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: August 11, 1992
    Assignee: Norwich Eaton Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, Kent W. Buckingham, Jocelyn E. McOsker
  • Patent number: 5128244
    Abstract: A screening assay for recognizing the presence of dioxins (and other related toxins) in a sample is disclosed. In one aspect of the invention, Ah receptor from mice and a radioactively labelled halogenated dioxin are used in a competitive binding assay to test for the presence of toxins. The label is .sup.125 I substituted directly on the main dioxin structure. The relative binding of the toxin in the samples (in competition with labelled dioxin) for Ah receptor can be compared against standard curves. A kit is provided for running such an assay and a preferred .sup.125 I ligand is provided.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: July 7, 1992
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Alan P. Poland, Christopher A. Bradfield, Edward N. Glover, Andrew S. Kende, Frank H. Ebetino
  • Patent number: 5071840
    Abstract: The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: December 10, 1991
    Assignee: Norwich Eaton Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, James J. Benedict
  • Patent number: 4963681
    Abstract: The present invention involves processes for making aminomethylene phosphonoalkylphosphinate compounds comprising:(a) heating a substantially anhydrous mixture comprising an amine, an ester of an alkyl phosphite, and an ester of a phosphate acetal; and then(b) adding water to the mixture.
    Type: Grant
    Filed: July 6, 1987
    Date of Patent: October 16, 1990
    Assignee: Norwich Eaton Pharmaceuticals, Inc.
    Inventor: Frank H. Ebetino
  • Patent number: 4868164
    Abstract: The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cyclopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: September 19, 1989
    Assignee: Norwich Eaton Pharmaceuticals, Inc.
    Inventors: Frank H. Ebetino, Kent W. Buckingham, Jocelyn E. McOsker