Patents by Inventor Frank Hacket

Frank Hacket has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150297738
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 22, 2015
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • Patent number: 8840879
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: September 23, 2014
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Wolfram Eichner, Martin Schimmel, Frank Hacket, Elmar Kraus, Norbert Zander, Ronald Frank, Harald Conradt, Klaus Langer, Michele Orlando, Klaus Sommermeyer
  • Publication number: 20140088298
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 27, 2014
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • Publication number: 20140073779
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • Publication number: 20140073778
    Abstract: The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken
  • Publication number: 20130230898
    Abstract: The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidised reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
    Type: Application
    Filed: February 19, 2013
    Publication date: September 5, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Frank Hacket, Thomas Hey, Franziska Hauschild, Helmut Knoller, Martin Schimmel, Klaus Sommermeyer
  • Publication number: 20130217871
    Abstract: The present invention relates to hydroxyalkyl starch conjugates and a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one primary hydroxyl group, wherein the hydroxyalkyl starch is linked via said primary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold and a molar substitution (MS) in the range of from 0.6 to 1.5.
    Type: Application
    Filed: July 11, 2011
    Publication date: August 22, 2013
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Saswata Lahiri, Nitin Gupta, Vivek Kumar, Mukesh Madan Mudgal
  • Publication number: 20130184454
    Abstract: The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken
  • Publication number: 20130184455
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • Publication number: 20130178437
    Abstract: The present invention relates to hydroxyalkyl starch (HAS) conjugates and to a method for preparing the hydroxyalkyl starch (HAS) conjugates, the hydroxyalkyl starch (HAS) conjugates comprising a hydroxyalkyl starch derivative and a cytotoxic agent, said conjugate having a structure according the following formula HAS?(-M)n wherein M is a residue of a cytotoxic agent, the cytotoxic agent comprising a carbonyl group, HAS? is a residue of the hydroxyalkyl starch derivative comprising at least one functional group X, n is greater than or equal to 1, and wherein the cytotoxic agent is linked via the carbonyl function present in the cytotoxic agent to the functional group X comprised in the hydroxyalkyl starch derivative, wherein the linkage via the carbonyl function is a cleavable linkage, which is capable of being cleaved in vivo so as to release the cytotoxic agent.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 11, 2013
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander
  • Patent number: 8404834
    Abstract: The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidized reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: March 26, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Frank Hacket, Thomas Hey, Franziska Hauschild, Helmut Knoller, Martin Schimmel, Klaus Sommermeyer
  • Patent number: 8287850
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: October 16, 2012
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Wolfram Eichner, Michele Orlando, Norbert Zander, Harald S. Conradt, Frank Hacket, Klaus Langer, Ronald Frank
  • Patent number: 8017739
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: September 13, 2011
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Wolfram Eichner, Martin Schimmel, Frank Hacket, Elmar Kraus, Norbert Zander, Ronald Frank, Harald Conradt, Klaus Langer, Michele Orlando, Klaus Sommermeyer
  • Publication number: 20110200555
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
    Type: Application
    Filed: February 1, 2011
    Publication date: August 18, 2011
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Wolfram Eichner, Martin Schimmel, Frank Hacket, Elmar Kraus, Norbert Zander, Ronald Frank, Harald Conradt, Klaus Langer, Michele Orlando, Klaus Sommermeyer
  • Publication number: 20100305033
    Abstract: The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidised reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
    Type: Application
    Filed: December 15, 2008
    Publication date: December 2, 2010
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Frank Hacket, Thomas Hey, Franziska Hauschild, Helmut Knoller, Martin Schimmel, Klaus Sommermeyer
  • Publication number: 20100297078
    Abstract: A method of producing a hydroxyalkyl starch (HAS) derivative, comprising a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups —O—NH2 or a salt thereof, and b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W1 and W2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.
    Type: Application
    Filed: December 15, 2008
    Publication date: November 25, 2010
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Frank Hacket, Wolfram Eichner, Helmut Knoller, Andreas Mitsch, Martin Schimmel, Norbert Zander, Franziska Hauschild
  • Publication number: 20090047251
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
    Type: Application
    Filed: September 8, 2006
    Publication date: February 19, 2009
    Inventors: Wolfram Eichner, Martin Schimmel, Frank Hacket, Elmar Kraus, Norbert Zander, Ronald Frank, Harald Conradt, Klaus Langer, Michele Orlando, Klaus Sommermeyer
  • Publication number: 20070134197
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
    Type: Application
    Filed: September 8, 2006
    Publication date: June 14, 2007
    Inventors: Wolfram Eichner, Michele Orlando, Norbert Zander, Harald Conradt, Frank Hacket, Klaus Langer, Ronald Frank