Patents by Inventor Frank Hallock Ebetino
Frank Hallock Ebetino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11400104Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.Type: GrantFiled: October 29, 2020Date of Patent: August 2, 2022Assignees: The Regents of the University of California, BioVinc LLC, University of Southern CaliforniaInventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
-
Publication number: 20210369849Abstract: Described herein are bisphosphonate oxazolidinone compounds, and conjugates and pharmaceutical formulations thereof, that can include a bisphosphonate and an oxazolidinone (or an oxazolidinone antimicrobial or antibiotic agent, substituent or derivative thereof), where the oxazolidinone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate oxazolidinone compounds, conjugates and pharmaceutical formulations thereof. Also provided herein are methods of use of the compounds, conjugates and formulations for treating a bone disease or for use in preparing a formulation for the treatment a bone disease.Type: ApplicationFiled: June 25, 2019Publication date: December 2, 2021Inventors: Frank Hallock EBETINO, Shuting SUN, Charles E. MCKENNA, Keivan SADRERAFI, Philip CHERIAN
-
Publication number: 20210121485Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.Type: ApplicationFiled: October 29, 2020Publication date: April 29, 2021Inventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
-
Patent number: 10857165Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.Type: GrantFiled: May 31, 2017Date of Patent: December 8, 2020Assignees: The Regents of the University of California, BioVinc LLC, University of Southern CaliforniaInventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
-
Publication number: 20190209590Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.Type: ApplicationFiled: May 31, 2017Publication date: July 11, 2019Inventors: Frank Hallock Ebetino, Ph.D., Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
-
Patent number: 8822435Abstract: Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.Type: GrantFiled: March 12, 2014Date of Patent: September 2, 2014Assignee: Warner Chilcott Company, LLCInventors: Frank Hallock Ebetino, Adam Wieslaw Mazur, Roy Lee Martin Dobson
-
Publication number: 20140194389Abstract: Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.Type: ApplicationFiled: March 12, 2014Publication date: July 10, 2014Applicant: WARNER CHILCOTT COMPANY, LLCInventors: Frank Hallock Ebetino, Adam Wieslaw Mazur, Roy Lee Martin Dobson
-
Patent number: 8710215Abstract: Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.Type: GrantFiled: October 12, 2012Date of Patent: April 29, 2014Assignee: Warner Chilcott Company, LLCInventors: Frank Hallock Ebetino, Adam Wieslaw Mazur, Roy Lee Martin Dobson
-
Patent number: 8618079Abstract: Novel imidazo[1,2-?]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.Type: GrantFiled: September 22, 2009Date of Patent: December 31, 2013Assignee: Isis Innovation LimitedInventors: Frank Hallock Ebetino, Adam Mazur, Mark Walden Lundy, Robert Graham Russell
-
Patent number: 8314081Abstract: Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.Type: GrantFiled: October 26, 2010Date of Patent: November 20, 2012Assignee: Warner Chilcott Company, LLCInventors: Frank Hallock Ebetino, Adam Wieslaw Mazur, Roy Lee Martin Dobson
-
Patent number: 8252774Abstract: Novel 5-azaindole bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.Type: GrantFiled: September 22, 2009Date of Patent: August 28, 2012Assignee: Isis Innovation Ltd.Inventors: Frank Hallock Ebetino, Adam Mazur, Mark Walden Lundy, Robert Graham Russell
-
Publication number: 20110237550Abstract: Novel 5-azaindole bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.Type: ApplicationFiled: September 22, 2009Publication date: September 29, 2011Applicant: ISIS INNOVATION LTD.Inventors: Frank Hallock Ebetino, Adam Mazur, Mark Walden Lundy, Robert Graham Russell
-
Publication number: 20110230443Abstract: Novel imidazo[1,2-?]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.Type: ApplicationFiled: September 22, 2009Publication date: September 22, 2011Applicant: ISIS INNOVATION LTD.Inventors: Frank Hallock Ebetino, Adam Mazur, Mark Walden Lundy, Robert Graham Russell
-
Publication number: 20110098251Abstract: Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.Type: ApplicationFiled: October 26, 2010Publication date: April 28, 2011Applicant: WARNER CHILCOTT COMPANY, LLCInventors: Frank Hallock Ebetino, Adam Wieslaw Mazur, Roy Lee Martin Dobson
-
Patent number: 7781418Abstract: Disclosed is a new composition of matter, substantially enantiomerically pure (1R,6S)-2-Azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, methods of preparing this new composition of matter, a pharmaceutical composition comprising the new composition, and administration of the composition in methods of treating bone disorders such as osteoporosis, osteolytic bone metastasis, rheumatoid arthritis and osteoarthritis.Type: GrantFiled: December 11, 2007Date of Patent: August 24, 2010Assignee: Isis Innovation Ltd.Inventors: Frank Hallock Ebetino, Robert Kenneth Boeckman, Jr., Xinyi Song
-
Publication number: 20090069272Abstract: Disclosed is a new composition of matter, substantially enantiomerically pure (1R,6S)-2-Azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, methods of preparing this new composition of matter, a pharmaceutical composition comprising the new composition, and administration of the composition in methods of treating bone disorders such as osteoporosis, osteolytic bone metastasis, rheumatoid arthritis and osteoarthritis.Type: ApplicationFiled: December 11, 2007Publication date: March 12, 2009Applicant: The Procter & Gamble Company and University of RochesterInventors: Frank Hallock Ebetino, Robert Kenneth Boeckman, JR., Xinyi Song
-
Patent number: 7132539Abstract: The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1–C12 linear or branched alkyl, C3–C8 cyclic alkyl, C2–C12 linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1 is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7a is selected from the group consisting of hydrogen, —CO2H, —CONH2, —CONHCH3, and —CON(CH3)2; R8 is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.Type: GrantFiled: October 20, 2003Date of Patent: November 7, 2006Assignee: The Procter & Gamble CompanyInventors: Frank Hallock Ebetino, Xinrong Tian, Wieslaw Adam Mazur, Anny-Odile Colson
-
Patent number: 7087759Abstract: Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic rings; b) aromatic carbocyclic rings; c) non-aromatic heterocyclic rings; d) aromatic heterocyclic rings; wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.Type: GrantFiled: May 28, 2004Date of Patent: August 8, 2006Assignee: The Procter & Gamble CompanyInventors: Wieslaw Adam Mazur, Xinrong Tian, Xiufeng Eric Hu, Frank Hallock Ebetino
-
Patent number: 7026335Abstract: The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein preferably R is substituted aryl, W is a pendant unit having the formula: -L-Q L is a linking unit, Q is preferably a cyclic hydrocarbyl unit; W1 is preferably a carbocyclic unit and W2 is a heteroatom comprising unit.Type: GrantFiled: April 9, 2003Date of Patent: April 11, 2006Assignee: The Procter & Gamble Co.Inventors: Frank Hallock Ebetino, Xuewei Liu, Mark Gregory Solinsky, John August Wos
-
Patent number: 6951916Abstract: Disclosed are MC-4 and/or MC-3 receptor ligands having the formula: wherein B is a suitable linking group comprising a least one amino acid.Type: GrantFiled: July 2, 2003Date of Patent: October 4, 2005Assignee: The Procter & Gamble CompanyInventors: Adam Wieslaw Mazur, Feng Wang, Russell James Sheldon, Frank Hallock Ebetino