Patents by Inventor Frank Herting

Frank Herting has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mono-acylated o-phenylendiamines derivatives
    Patent number: 7501451
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A: which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: March 10, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors
    Patent number: 7423060
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: September 9, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • Thiophene derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7396944
    Abstract: Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: July 8, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • Hydroxamates, Their Manufacture And Use As Pharmaceutical Agents
    Publication number: 20080139640
    Abstract: Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the In preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 13, 2005
    Publication date: June 12, 2008
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors
    Publication number: 20080070976
    Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 13, 2005
    Publication date: March 20, 2008
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • Thiophene Derivatives, Their Manufacture and Use as Pharmaceutical Agents
    Publication number: 20070232602
    Abstract: Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 13, 2005
    Publication date: October 4, 2007
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • N-monoacylated o-phenylenediamines
    Patent number: 7208491
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Treatment of neurodegenerative disorders
    Publication number: 20070072795
    Abstract: A method of treating neurodegenerative disorders of the brain and spinal cord using a novel ethropoietic agent.
    Type: Application
    Filed: September 28, 2005
    Publication date: March 29, 2007
    Inventors: Anton Haselbeck, Frank Herting, Joerg Huwyler, Michael Jarsch
  • Oxime derivatives and their use as pharmaceutically active agents
    Patent number: 7173060
    Abstract: The present invention relates to compounds of formula I, their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds as inhibitors of histone deacetylase (HDAC) and therefore in the control or prevention of illnesses and disorders as mentioned above, or in the manufacture of corresponding pharmaceutical compositions.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: February 6, 2007
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
    Patent number: 7098247
    Abstract: The present invention describes compounds of the general formula I as well as processes for their manufacture, pharmaceutical compositions containing them and methods for using these compounds and pharmaceutical compositions as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 29, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Thiophene hydroxamic acid derivatives
    Patent number: 7098241
    Abstract: The (R) and (S) enantiomers of a compound of formula I are novel antiproliferative therapeutic agents. These compounds have HDAC inhibitor activity and are useful in the treatment of cancer. Also disclosed are methods of making and using compounds of formula (I), as well as pharmaceutical compositions containing compounds of formula (I).
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 29, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Adelbert Grossmann, Frank Herting, Matthias Koerner, Klaus-Peter Kuenkele, Anja Limberg, Olaf Mundigl, Ulrich Tibes
  • Mono-acylated o-phenylendiamines derivatives
    Patent number: 7071219
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A wherein Ar, R1, and R2 are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: July 4, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Mono-acylated o-phenylendiamines derivatives
    Publication number: 20060089403
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A: which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Application
    Filed: December 6, 2005
    Publication date: April 27, 2006
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Oxime derivatives and their use as pharmaceutically active agents
    Publication number: 20040214880
    Abstract: The present invention relates to compounds of formula I, 1
    Type: Application
    Filed: March 31, 2004
    Publication date: October 28, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Mono-acylated o-phenylendiamines derivatives
    Publication number: 20040162317
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 19, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • N-monoacylated o-phenylenediamines
    Publication number: 20040157841
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula I 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 12, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
    Publication number: 20040138270
    Abstract: The present invention describes compounds of the general formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Thiophene hydroxamic acid derivatives
    Publication number: 20040122079
    Abstract: The (R) and (S) enantiomers of a compound of formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Inventors: Adelbert Grossmann, Frank Herting, Matthias Koerner, Klaus-Peter Kuenkele, Anja Limberg, Olaf Mundigl, Ulrich Tibes