Patents by Inventor Frank Himmelsbach

Frank Himmelsbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20060035841

Abstract: A D-Xylopyranosyl-phenyl-substituted cycle compound of general formula I wherein the groups R1 to R6, Z, X, Cy and R7a, R7b and R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.

Type: Application

Filed: August 9, 2005

Publication date: February 16, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders

Publication number: 20060035893

Abstract: The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

Type: Application

Filed: July 26, 2005

Publication date: February 16, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Birgit Jung, Frank Himmelsbach
D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20060025349

Abstract: D-Glucopyranosyl-phenyl-substituted cycles of general formula I wherein the groups R1 to R6, Z, Cy and R7a, R7b, R7c, R7d are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.

Type: Application

Filed: July 27, 2005

Publication date: February 2, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
Methylidene-D-xylopyranosyl- and oxo-D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20060019948

Abstract: D-Xylopyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.

Type: Application

Filed: July 15, 2005

Publication date: January 26, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20060009400

Abstract: A D-Xylopyranosyl-substituted phenyl compound of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.

Type: Application

Filed: June 28, 2005

Publication date: January 12, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
New imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions

Publication number: 20060004074

Abstract: The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: June 24, 2005

Publication date: January 5, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Elke Langkopf, Leo Thomas, Mohammad Tadayyon
4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

Patent number: 6972288

Abstract: The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.

Type: Grant

Filed: February 24, 2000

Date of Patent: December 6, 2005

Assignee: Boehringer Ingelheim Pharma KG

Inventors: Frank Himmelsbach, Elke Langkopf, Birgit Jung, Thomas Metz, Flavio Solca, Stefan Blech
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions

Publication number: 20050234108

Abstract: The present invention relates to substituted xanthines of general formula wherein R is defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: February 17, 2005

Publication date: October 20, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Mohammad Tadayyon, Leo Thomas
Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof

Publication number: 20050233982

Abstract: The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on the sodium-dependent glucose cotransporter SGLT2, the use thereof for the treatment of diseases, particularly metabolic disorders such as diabetes, and the preparation thereof.

Type: Application

Filed: August 24, 2004

Publication date: October 20, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions

Publication number: 20050234235

Abstract: The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: April 8, 2005

Publication date: October 20, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Elke Langkopf, Norbert Hauel, Mohammad Tadayyon, Leo Thomas
Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20050209166

Abstract: Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

Type: Application

Filed: March 15, 2005

Publication date: September 22, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Peter Eickelmann, Frank Himmelsbach, Edward Barsoumian, Leo Thomas
Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions

Publication number: 20050203095

Abstract: The invention relates to substituted imidazopyridazinediones of general formula wherein R1 and R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: March 9, 2005

Publication date: September 15, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Frank Himmelsbach, Iris Kauffmann-Hefner, Elke Langkopf, Mohammad Tadayyon, Leo Thomas
Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture

Publication number: 20050187168

Abstract: The present invention relates to glucopyranosyloxy-substituted aromatic groups of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on the sodium-dependent glucose cotransporter SGLT2, the use thereof for the treatment of diseases, particularly metabolic disorders such as diabetes, and the preparation thereof.

Type: Application

Filed: December 21, 2004

Publication date: August 25, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Peter Eickelmann, Frank Himmelsbach, Edward Barsoumian
8-[3-Amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition

Publication number: 20050187227

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 and R2 are defined as in the claims, the tautomers, the stereoisomers, the mixtures thereof, and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: February 22, 2005

Publication date: August 25, 2005

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Mohammad Tadayyon, Leo Thomas
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them

Publication number: 20050182043

Abstract: The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.

Type: Application

Filed: March 17, 2005

Publication date: August 18, 2005

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions

Publication number: 20050171093

Abstract: The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: December 17, 2004

Publication date: August 4, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Matthias Eckhardt, Norbert Hauel, Frank Himmelsbach, Iris Kauffman-Hefner, Elke Langkopf, Mohammad Tadayyon, Leo Thomas
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them

Patent number: 6924285

Abstract: The present invention relates to bicyclic heterocyclic groups of general formula wherein Ra, Rb, Rc, Rd and X are defined as in claim 1, the tautomers, the stereoisomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, as well as benign prostate hyperplasia (BPH), diseases of the lungs and respiratory tract, and the preparation thereof.

Type: Grant

Filed: March 27, 2003

Date of Patent: August 2, 2005

Assignee: Boehringer Ingelheim Pharma GmbH & Co.

Inventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

Publication number: 20050159436

Abstract: The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb, Rc, A, B, C, D, E and X are defined as in claim 1, the tautomers, the stereoisomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the preparation thereof.

Type: Application

Filed: March 15, 2005

Publication date: July 21, 2005

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions

Publication number: 20050143377

Abstract: The present invention relates to bicyclic imidazole compounds of general formula wherein R1 to R3 and A are defined as in claims 1 to 8, the tautomers, the enantiomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: December 21, 2004

Publication date: June 30, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Norbert Hauel, Mohammad Tadayyon, Leo Thomas
8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition

Publication number: 20050130985

Abstract: The present invention relates to substituted xanthines of the general formula in which R1 to R3 and n are as defined in claims 1 to 8, their tautomers, their enantiomers, their diastereomers, their mixtures, their prodrugs and their salts, which have valuable pharmacological properties, in particular an inhibitory action on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Type: Application

Filed: November 2, 2004

Publication date: June 16, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Mohammad Tadayyon, Leo Thomas

prev … 11 12 13 14 15 16 17 18 19 next