Abstract: Disclosed herein are recombinant antibodies or a fragment thereof. According to some embodiments of the present disclosure, each of the recombinant antibodies exhibits a binding affinity to and a neutralizing effect on parathyroid hormone-related protein. Also disclosed herein are pharmaceutical compositions comprising the antibodies or antibody fragments, and uses thereof in treating cancers.

Abstract: Presented herein are systems and methods of authenticating clients to access data via proxy layers. A gateway on a proxy layer may receive a request from a client to access data in a compartment on the database layer. The request may include a token based at least on an encryption of an identifier of the compartment responsive to successful authentication of the request at an application layer. The gateway may, responsive to identifying the identifier as referencing the compartment, determine that the client is authorized to access the data in the compartment on the database layer through the proxy layer. The gateway may select a permission for the client to access the compartment through the proxy layer based on the context of the request. The gateway may generate an indication that the client is authorized to access the data in accordance with the permission.

Abstract: A method includes providing a neural network with metrics obtained from an execution of an application in a test environment to determine rule-related weights, scaling rule results with the rule-related weights to determine scaled rule results. The method also includes re-training the neural network with the rule results of the application, an indication that the executed application is selected for deployment in the production environment, and rule results of other applications in the test environment in response to a determination that the scaled rule results fail a threshold but that the application is selected for deployment in a production environment. The method also includes providing the re-trained neural network with the rule results to generate updated rule-related weights and scaling the rule results by the updated rule-related weights to determine updated scaled rule results.

Abstract: A blade assembly for a folding knife includes a blade and a bearing assembly. The blade includes a cutting portion and a tang portion. The tang portion comprises a pivot opening, a first recess, and a second recess. The bearing assembly is coupled to the blade and includes a first bearing member, a second bearing member, and a sleeve. The first bearing member is disposed within the first recess of the tang portion, the second bearing member is disposed within the second recess of the tang portion, and the sleeve extends through the first bearing member, the second bearing member, and the pivot opening of the tang portion.

Abstract: A method includes providing a neural network with metrics obtained from an execution of an application in a test environment to determine rule-related weights, scaling rule results with the rule-related weights to determine scaled rule results. The method also includes re-training the neural network with the rule results of the application, an indication that the executed application is selected for deployment in the production environment, and rule results of other applications in the test environment in response to a determination that the scaled rule results fail a threshold but that the application is selected for deployment in a production environment. The method also includes providing the re-trained neural network with the rule results to generate updated rule-related weights and scaling the rule results by the updated rule-related weights to determine updated scaled rule results.

Abstract: A blade assembly for a folding knife includes a blade and a bearing assembly. The blade includes a cutting portion and a tang portion. The tang portion comprises a pivot opening, a first recess, and a second recess. The bearing assembly is coupled to the blade and includes a first bearing member, a second bearing member, and a sleeve. The first bearing member is disposed within the first recess of the tang portion, the second bearing member is disposed within the second recess of the tang portion, and the sleeve extends through the first bearing member, the second bearing member, and the pivot opening of the tang portion.

Abstract: Methods and systems for searching directory access groups are disclosed. A set of groups associated with a logon user is determined. The set of groups is partitioned into one or more disjoint subsets, wherein each of the disjoint subsets is represented by a data representation including a root node and one or more intermediate nodes. For each of the disjoint subsets, the disjoint subset is path compressed to flatten a structure of the data representation representing the disjoint subset. The data representation is cached to a database cache.

Abstract: A folding knife includes a blade, a handle, an actuation mechanism, and a switch. The handle includes first and second side portions. The blade is pivotably coupled to the first and second side portions. The actuation mechanism is coupled to the handle and is movable between engaged and disengaged configurations. In the engaged configuration, the actuation mechanism prevents relative movement between the first and second side portions of the handle in a first direction. In the disengaged configuration, the actuation mechanism allows relative movement between the first and second side portions of the handle in the first direction. The switch is coupled to the handle and the actuation mechanism. The switch is configured such that moving the switch along a first path retains the actuation mechanism in the engaged configuration and moving the switch along a second path moves the actuation mechanism between the engaged and disengaged configurations.

Abstract: A method for controlling a playback tempo of an audio track to be presented at an audio output, the audio track comprising a plurality of audio components, a first audio component of the plurality of audio components being associated with a plurality of sets of audio data, wherein each set of audio data in the plurality of sets of audio data is associated with a respective playback tempo range, the method comprising receiving a playback tempo for presenting the audio track at the audio output, selecting, from the plurality of sets of audio data, a set of audio data that has an associated playback tempo range comprising the received playback tempo, and allocating the selected set of audio data to the first audio component for presenting the audio track at the audio output.

Abstract: A method for controlling a playback tempo of an audio track to be presented at an audio output, the audio track comprising a plurality of audio components, a first audio component of the plurality of audio components being associated with a plurality of sets of audio data, wherein each set of audio data in the plurality of sets of audio data is associated with a respective playback tempo range, the method comprising receiving a playback tempo for presenting the audio track at the audio output, selecting, from the plurality of sets of audio data, a set of audio data that has an associated playback tempo range comprising the received playback tempo, and allocating the selected set of audio data to the first audio component for presenting the audio track at the audio output.

Abstract: A wireless data transceiver includes a media access controller (MAC) that receives an inbound packet from an air interface and to buffer that packet for transport to a host, and receives an outbound packet and transfers that packet to the air interface. A host interface receives the inbound packet from the MAC and transfers the inbound packet to the host, and receives the outbound packet from the host for transfer to the MAC. Transport controller circuitry (TCC), including processing circuitry configured to execute instructions, manages the transceiver. Hardware data transport circuitry (HDTC) for transporting packets in either direction between the MAC and the host interface includes a buffer memory having a plurality of slots. The TCC or HDTC issues a start or stop signal to the host interface causing the HDTC and the host interface to begin or end transfer of data between the buffer memory and the host interface.

Abstract: A method for controlling a playback tempo of an audio track to be presented at an audio output, the audio track comprising a plurality of audio components, a first audio component of the plurality of audio components being associated with a plurality of sets of audio data, wherein each set of audio data in the plurality of sets of audio data is associated with a respective playback tempo range, the method comprising receiving a playback tempo for presenting the audio track at the audio output, selecting, from the plurality of sets of audio data, a set of audio data that has an associated playback tempo range comprising the received playback tempo, and allocating the selected set of audio data to the first audio component for presenting the audio track at the audio output.

Abstract: A distributed search framework with virtual indexing is disclosed. According to some embodiments, a virtual index that includes a first physical index is created, where the first physical index includes a first number of shards. A request to index a document is received. In response to the request, whether the first physical index has reached a capacity threshold is determined. In response to determining that the first physical index has reached the capacity threshold, a second physical index is automatically created and added to the virtual index, where the second physical index includes a second number of shards. The document is added into the second physical index.

Abstract: A wireless network interface generates a beacon frame, and transmits the beacon frame outside of a wireless local area network (WLAN) served by an access point (AP). Additionally or alternatively, the wireless network interface receives a first probe request frame from a client station in the WLAN, and in response, generates and transmits a probe response frame outside of the WLAN. The wireless network interface receives one or more frames from the client station of the WLAN, the one or more frames having been transmitted outside of the WLAN. Network security information corresponding to the WLAN is extracted from the one or more frames, and the wireless network interface uses the network security information to wirelessly connect to the AP as part of the WLAN.

Abstract: A method for constructing an adaptive media file comprising a plurality of audio components configured to be used to form an audio output arranged to have a controllable tempo, the method comprising providing first audio data associated with a first audio component of the plurality of audio components, setting a playback tempo range of the first audio data, providing second audio data associated with the first audio component, setting a playback tempo range of the second audio data, wherein the tempo range of the second audio data is different to the tempo range of the first audio data, and associating the first audio data, the second audio data and the respective playback tempo ranges.

Abstract: A folding knife includes a blade, a handle, an actuation mechanism, and a switch. The handle includes first and second side portions. The blade is pivotably coupled to the first and second side portions. The actuation mechanism is coupled to the handle and is movable between engaged and disengaged configurations. In the engaged configuration, the actuation mechanism prevents relative movement between the first and second side portions of the handle in a first direction. In the disengaged configuration, the actuation mechanism allows relative movement between the first and second side portions of the handle in the first direction. The switch is coupled to the handle and the actuation mechanism. The switch is configured such that moving the switch along a first path retains the actuation mechanism in the engaged configuration and moving the switch along a second path moves the actuation mechanism between the engaged and disengaged configurations.

Abstract: A wireless data transceiver includes a media access controller (MAC) configured to receive an inbound data packet from an air interface and to buffer the inbound packet for transport to a host, and to receive an outbound data packet from elsewhere in the transceiver and to transfer the outbound packet to the air interface. The transceiver further includes a host interface configured to receive the inbound packet transported from the MAC and to transfer the inbound packet to the host, and to receive the outbound packet from the host for transfer to the MAC. The transceiver also includes transport controller circuitry configured to execute instructions to generate and transfer management packets. In addition, the wireless data transceiver includes hardware data transport circuitry for transporting the inbound packet from the MAC to the host interface, and for transporting the outbound packet from the host interface to the MAC, without executing instructions.

Abstract: A folding knife includes a blade, first and second handle portions, a post, and an engaging plate. The post extends from the first handle portion. The blade is pivotable relative to the handle portions about a pivot axis between open and closed positions. The engaging plate is coupled to the second handle portion and is movable relative to the second handle portion between first and second positions. In the first position, the engaging plate engages the post, thereby restricting relative movement between the first and second handle portions in a direction parallel to the pivot axis and retaining the blade between the first and second handle portions. In the second position, the engaging plate disengages the post, thereby allowing relative movement between the first and second handle portions in the direction parallel to the pivot axis and allowing the blade to be separated from the first and second handle portions.

Abstract: Provided is a method in a device under configuration (DUC) for communicating with a remote device over a wireless local area network. The method comprises transmitting a beacon to a remote device, providing a first security key to the remote device using first security measures, authenticating the remote device using second security measures, receiving encrypted secrets from the remote device, and obtaining network access using the secrets. Also, provided is a method of providing network access information over a wireless network. The method comprises identifying a device under configuration (DUC) from information contained in a beacon transmitted by the DUC, retrieving a public KEY from the DUC, authenticating the DUC using first security measures, encrypting secrets, and transmitting encrypted commands to the DUC.

Abstract: A folding knife can include a handle portion, a pivot element, a blade, a locking element, a cap, and a rotatable wheel. The handle portion can comprise a first side portion and a second side portion. The blade can pivot about the pivot element between an open position and a closed position. The locking element can prevent disassembly of the first and second side portions when the locking element is in a locked position and allow disassembly of the first and second side portions when the locking element is in an unlocked position. The cap can be coupled to the first side portion adjacent the locking element. The pivot element can extend into the cap. The rotatable wheel can be disposed between the first and second side portions and can rotated to selectively retain the first and second side portions together.