Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A system and method for mitigating interference of a radio frequency (RF) signal includes a receiver configured to include: a decomposition module that decomposes a received RF signal into sub-bands via a multi-stage filter, each sub-band being configured to operate on real and imaginary components of the RF signal, and each stage being scaled for separating time-frequency content of the desired signal from time-frequency content of the interference; a mitigation module that suppresses the interference of the RF signal in each sub-band by zeroing an output of a respective sub-band when the frequency content exceeds a predetermined threshold; and a reconstruction module that reconstructs the RF signal from the mitigation module minus the interference. The receiver is configured to determine whether the multi-stage filter is to be reinitialized with updated time and frequency resolution requirements to improve system response.

Abstract: A system and method for mitigating interference of a radio frequency (RF) signal includes a receiver configured to include: a decomposition module that decomposes a received RF signal into sub-bands via a multi-stage filter, each sub-band being configured to operate on real and imaginary components of the RF signal, and each stage being scaled for separating time-frequency content of the desired signal from time-frequency content of the interference; a mitigation module that suppresses the interference of the RF signal in each sub-band by zeroing an output of a respective sub-band when the frequency content exceeds a predetermined threshold; and a reconstruction module that reconstructs the RF signal from the mitigation module minus the interference. The receiver is configured to determine whether the multi-stage filter is to be reinitialized with updated time and frequency resolution requirements to improve system response.

Abstract: A coupled spin-draw process for making a fully-oriented nylon yarn including extruding molten nylon polymer with a selected RV through a spinneret and cooling to produce a yarn. The yarn is withdrawn from the quench zone with a feed roll rotating at a speed of at least 4500 mpm. The process further includes cold drawing followed by relaxing the yarn using a steam intermingling jet and then winding up.

Abstract: A coupled spin-draw process for making a fully-oriented nylon yarn including extruding molten nylon polymer with a selected RV through a spinneret and cooling to produce a yarn. The yarn is withdrawn from the quench zone with a feed roll rotating at a speed of at least 4500 mpm. The process further includes cold drawing followed by relaxing the yarn using a steam intermingling jet and then winding up.