Patents by Inventor Frank J. Massino

Frank J. Massino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions
    Patent number: 8575182
    Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 5, 2013
    Assignee: Institute of Experimental Botany, Academy of Sciences of the Czeck Republic
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • Heterocyclic compounds based on N-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
    Patent number: 8552013
    Abstract: Novel heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: October 8, 2013
    Assignee: USTAV Experimentalni Botaniky Akademie Ved Ceske Republiky
    Inventors: Igor Popa, Jan Holub, René Lenobel, Stefaan Werbrouck, Karel Dolezal, Miroslav Strnad, Marek Zatloukal, Frank J. Massino
  • 6,9-Disubstituted Purine Derivatives and Their Use for Treating Skin
    Publication number: 20130072505
    Abstract: The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 21, 2013
    Inventors: Lucie Szucova, Marek Zatioukai, Lukas Spichal, Ludek Frohich, Karel Dolezal, Miroslav Stmad, Frank J. Massino
  • 6, 9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions
    Publication number: 20110230503
    Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 22, 2011
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • 6, 9-Disubstituted Purine Derivatives and Their Use for Treating Skin
    Publication number: 20110224238
    Abstract: The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 15, 2011
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Ludek Frolich, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • 6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions
    Patent number: 7960397
    Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: June 14, 2011
    Assignee: Institute of Experimental Botany, Academy of Sciences of the Czech Republic
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • 6,9-Disubstituted Purine Derivatives and Their Use For Treating Skin
    Publication number: 20100234401
    Abstract: The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
    Type: Application
    Filed: May 24, 2010
    Publication date: September 16, 2010
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Ludek Frohlich, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • 6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions
    Publication number: 20090170879
    Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
    Type: Application
    Filed: December 28, 2007
    Publication date: July 2, 2009
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Jiri Voller, Karel Dolezal, Miroslav Strnad, Frank J. Massino
  • 6,9-Disubstituted Purine Derivatives And Their Use For Treating Skin
    Publication number: 20080009508
    Abstract: The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
    Type: Application
    Filed: July 9, 2007
    Publication date: January 10, 2008
    Inventors: Lucie Szucova, Marek Zatloukal, Lukas Spichal, Ludek Frohlich, Karel Dolezal, Miroslav Strnad, Frank J. Massino