Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described. A composition for use in diagnosing and treating cancer related to PMN-MDSC is provided that contains antagonists and/or inhibitors of genes related to the ER stress response.

Abstract: Provided herein are methods and compositions comprising a set of paired peptides comprising a first bacterial effector polypeptide or fragment thereof linked to a second bacterial effector polypeptide or fragment thereof. The paired peptides can be linked to a protein transduction domain. The compositions can be formulated as pharmaceuticals. The compositions are useful for the treatment of inflammatory disorders.

Abstract: Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in undesired frequency of urination an effective amount of a pharmaceutical composition comprising one or more prostaglandin pathway inhibitors. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in undesired frequency of urination an effective amount of a pharmaceutical composition comprising one or more prostaglandin pathway inhibitors. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in undesired frequency of urination an effective amount of a pharmaceutical composition comprising one or more prostaglandin pathway inhibitors. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in undesired frequency of urination an effective amount of a pharmaceutical composition comprising one or more prostaglandin pathway inhibitors. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier.

Abstract: Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in undesired frequency of urination an effective amount of a pharmaceutical composition comprising one or more prostaglandin pathway inhibitors. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier.

Abstract: Nucleic acid and amino acid sequences of a BRCA1 associated protein, BAP-1, are provided. These sequences, the protein, and anti-BAP-1 antibodies are useful in therapeutics and diagnostics for cancers associated with loss of the 3p21 chromosomal region and/or inappropriate BAP-1 levels.

Abstract: The present invention provides three unique monoclonal antibodies directed against a portion of the Wilms' tumor antigen, and methods of use therefor in detecting, monitoring and diagnosing malignancies characterized by over-expression or inappropriate expression of the WT 1 protein.

Abstract: Three unique monoclonal antibodies, each having an epitope located in amino acids 1-181 of the WT1 tumor protein, and the hybridomas which secrete them have been constructed. These monoclonal antibodies are useful in the detection, monitoring, and diagnosis of malignancies characterized by inappropriate expression of the WT1 protein.

Abstract: A venipuncture site protector to be secured to a patient over a venipuncture site containing an intravenous needle for shielding the site and needle against contact by other objects which would cause trauma to the endothelial lining of the venal wall, pain and discomfort to the patient, and other adverse effects. The protector has a body including a relatively rigid cup-like shield of frustro-pyramidal shape and mounting tabs extending from the shield, these tabs are taped to the patient's body with the shield positioned over the venipuncture site and the intravenous needle entering the shield through a side opening. The protector body is constructed of relatively thin, stiff but readily bendable material having a low modulus of elasticity such that the protector may be bent without appreciable springback to accommodate the protector to the patient's body surface contour at the venipuncture site.

Abstract: An intravenous alarm device provides an alarm signal to indicate that a predetermined amount of liquid remains in a liquid dispensing container of the type such as an I.V. bottle or bag adapted to be suspended from an arm. The device includes an attitude-sensitive transducer such as a mercury switch defining a reference axis, and the alarm signal is given when the reference axis extends along a line in predetermined angular relationship with the horizontal. The device further includes a structure supporting the transducer, with the structure including, at a first point thereof, a hanger portion to suspend the device from such an arm; at a second point thereof, a holding portion to suspend the container from the device; and, at a third point thereof, a device center of gravity. The first, second, and third points are spaced to define vertices of a triangle.

Abstract: A plastic-cabinet-confined, battery-energized, electric-motor-powered, push-button-switch-controlled, tube-squeezing paste dispenser which extrudes paste when the push-button is held closed and retracts back into the tube paste dripping therefrom when said push-button is released.