Patents by Inventor Frank J. Villani

Frank J. Villani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel crystals and process of making 5-(-METHYL)-2-METHOXY-BENZOIC ACID
    Publication number: 20140011851
    Abstract: The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
    Type: Application
    Filed: June 24, 2013
    Publication date: January 9, 2014
    Inventors: Luigi Anzalone, Frank J. Villani, Christopher A. Teleha, Penina Feibush, Barry Fegely
  • Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
    Patent number: 8609865
    Abstract: The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: December 17, 2013
    Assignee: Furiex Pharmaceuticals, Inc.
    Inventors: Luigi Anzalone, Frank J. Villani, Christopher A. Teleha, Penina Feibush, Barry Fegely
  • Process for the preparation of chymase modulators
    Patent number: 8378122
    Abstract: The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: February 19, 2013
    Assignee: Janssen Pharmaceutica NV.
    Inventors: Luigi Anzalone, Penina Feibush, Ilias Konstantinos Dorziotis, Frank J. Villani
  • PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS
    Publication number: 20120309986
    Abstract: The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: August 9, 2012
    Publication date: December 6, 2012
    Inventors: Luigi Anzalone, Penina Feibush, IIias Konstantinos Dorziotis, Xun Li, Frank J. Villani
  • PROCESS FOR SYNTHESIZING PHOSPHONIC AND PHOSPHINIC ACID COMPOUNDS
    Publication number: 20120259130
    Abstract: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 11, 2012
    Inventors: Luigi Anzalone, Daniel J. Pippel, Neelakandha S. Mani, Penina Feibush, IIias K. Dorziotis, Stefan Horns, Frank J. Villani, JR.
  • Process for the preparation of chymase modulators
    Patent number: 8263785
    Abstract: The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: September 11, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Luigi Anzalone, Penina Feibush, Ilias Konstantinos Dorziotis, Xun Li, Frank J. Villani
  • Process for synthesizing phosphonic and phosphinic acid compounds
    Patent number: 8222431
    Abstract: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: July 17, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Luigi Anzalone, Daniel J. Pippel, Neelakandha S. Mani, Penina Feibush, Ilias K. Dorziotis, Stefan Horns, Frank J. Villani, Jr.
  • Liquid phase peptide synthesis of KL-4 pulmonary surfactant
    Patent number: 8217142
    Abstract: The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 10, 2012
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ahmed F. Abdel-Magid, Urs Eggmann, Cynthia Anne Maryanoff, Adrian Thaler, Frank J. Villani
  • NOVEL CRYSTALS AND PROCESS OF MAKING 5-(-METHYL)-2-METHOXY-BENZOIC ACID
    Publication number: 20110263868
    Abstract: The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 27, 2011
    Inventors: Luigi Anzalone, Frank J. Villani, Christopher A. Teleha, Penina Feibush, Barry Fegely
  • Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
    Patent number: 7994206
    Abstract: The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: August 9, 2011
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Luigi Anzalone, Frank J. Villani, Christopher A. Teleha, Penina Feibush, Barry Fegely
  • Sulfamide derivative useful for the treatment of epilepsy
    Patent number: 7897636
    Abstract: The present invention is directed to novel sulfamide derivatives, pharmaceutical compositions comprising said compounds and methods for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, said compounds, either alone or as co-therapy with one or more anticonvulsant and/or anti-epileptic agents.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: March 1, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael Breslav, Brian Klein, Xun Li, John A. Moyer, Frank J. Villani
  • Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives
    Patent number: 7872138
    Abstract: The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: January 18, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Frank J. Villani, Hua Zhong
  • SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20100267701
    Abstract: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Inventors: John M. Keith, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
  • Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
    Patent number: 7777031
    Abstract: Processes are disclosed for making certain compounds of Formula (II): or their pharmaceutically active salts, that are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases. In one embodiment, the process comprises reacting a compound of formula (7-1): with a compound of formula (B3): in the presence of at least one equivalent of a first base, in a first organic solvent, to give a compound of Formula (II).
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 17, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
  • PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS
    Publication number: 20100145075
    Abstract: The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: October 29, 2009
    Publication date: June 10, 2010
    Inventors: Luigi Anzalone, Penina Feibush, Ilias Konstantinos Dorziotis, Xun Li, Frank J. Villani
  • PROCESS FOR THE PREPARATION OF PROTECTED L ALANINE DERIVATIVES
    Publication number: 20100145090
    Abstract: The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.
    Type: Application
    Filed: October 27, 2009
    Publication date: June 10, 2010
    Inventors: Luigi ANZALONE, Penina FEIBUSH, Frank J. VILLANI
  • Compounds having inhibitory activity against sodium-dependent glucose transporter
    Patent number: 7666845
    Abstract: The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: February 23, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Kevin L. Cook, Heng-Keang Lim, Frank J. Villani, Lorraine Scott, Christian Andrew Baumann
  • Liquid Phase Peptide Synthesis of KL-4 Pulmonary Surfactant
    Publication number: 20090259021
    Abstract: The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Application
    Filed: September 30, 2008
    Publication date: October 15, 2009
    Inventors: Ahmed F. Abdel-Magid, Urs Eggmann, Cynthia Anne Maryanoff, Adrian Thaler, Frank J. Villani
  • SULFAMIDE DERIVATIVE USEFUL FOR THE TREATMENT OF EPILEPSY
    Publication number: 20090176865
    Abstract: The present invention is directed to novel sulfamide derivatives, pharmaceutical compositions comprising said compounds and methods for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, said compounds, either alone or as co-therapy with one or more anticonvulsant and/or anti-epileptic agents.
    Type: Application
    Filed: August 7, 2008
    Publication date: July 9, 2009
    Inventors: Michael Breslav, Brian Klein, John A. Moyer, Frank J. Villani
  • Process for synthesizing phosphonic and phosphinic acid compounds
    Publication number: 20090124801
    Abstract: The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
    Type: Application
    Filed: October 16, 2008
    Publication date: May 14, 2009
    Inventors: Luigi Anzalone, Daniel J. Pippel, Neelakandha S. Mani, Penina Feibush, Ilias K. Dorziotis, Stefan Horns, Frank J. Villani, JR.