Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: The runtime retargeting approaches discussed herein can enable real time adaptation of character and object motion. In particular, fixed-source motion can be dynamically adjusted to variable situations encountered during runtime. In this way, the runtime retargeting approaches discussed herein can preserve the intent, visual quality, and essence of such fixed-source motion, while modifying it to meet new physical constraints or goals.

Abstract: A method executed by a computing device includes determining that a set of words are included in a word set. The method further includes determining a set of identigens for each word of the word set to produce sets of identigens, where a set of identigens of the sets of identigens represents one or more different meanings of a word of the word set. The method further includes interpreting, using identigen pairing rules, the sets of identigens to produce an entigen set. The method further includes assigning a single new entigen to represent the entigen set, where the single new entigen represents a most likely meaning interpretation of the word set.

Abstract: Methods for filling gaps with dielectric material involve deposition using an atomic layer deposition (ALD) technique to fill a gap followed by deposition of a cap layer on the filled gap by a chemical vapor deposition (CVD) technique. The ALD deposition may be a plasma-enhanced ALD (PEALD) or thermal ALD (tALD) deposition. The CVD deposition may be plasma-enhanced CVD (PECVD) or thermal CVD (tCVD) deposition. In some embodiments, the CVD deposition is performed in the same chamber as the ALD deposition without intervening process operations. This in-situ deposition of the cap layer results in a high throughput process with high uniformity. After the process, the wafer is ready for chemical-mechanical planarization (CMP) in some embodiments.

Abstract: Aspects of the present disclosure include systems, apparatuses, or methods for a system for reducing battery cell failure propagation risk includes a rechargeable battery including a plurality of rechargeable cells connected in series, parallel, or a combination of series and parallel and a BMS coupled with the battery. The BMS includes a processor and a memory including computer-executable instructions to receive information indicative of a status of each of the rechargeable cells; determine that a particular rechargeable cell is likely in a failure condition; identify a group of rechargeable cells that is in within one hop of the rechargeable cell that is likely in the failure condition; couple the group of rechargeable cells to a discharging system without coupling the rechargeable cell in the failure condition to the discharging system; and discharge the group of rechargeable cells to a target SOC.

Abstract: A method includes generating a content entigen group for content using identigen pairing rules. The method further includes obtaining a contradicting entigen group based on the content entigen group. The method further includes updating the knowledge database to include the content entigen group. A contradicted entigen of the content entigen group is established to indicate duplication of a contradicted entigen of the contradicting entigen group.

Abstract: A trunnion-to-disk connection for use on an open fan configuration of a gas turbine engine may include an integral trunnion and blade spar inserted through a trunnion aperture of a fan disk and supported by top bearing and a bottom bearing. A cavity can be provided between a trunnion of the integral trunnion and blade spar and the fan disk, as well as between the top bearing and bottom bearing. Pressurized hydraulic fluid can be supplied to the cavity to urge the integral trunnion and blade spar in a direction to preload the bearings. Prior to pressurization, and prior to installation of the bottom bearing, the trunnion can be inserted into a trunnion aperture of the fan disk such that an end of the trunnion extends past the fan disk to provide sufficient space to insert the bottom bearing from within the open interior of the fan disk.

Abstract: A method includes selecting an entigen group from a knowledge database. The entigen group is a most likely meaning of a phrase of a string of words. An entigen of the entigen group corresponds to a selected identigen from a set of identigens regarding a word of the string of words. The set of identigens represent different meanings of the word. The method further includes identifying other entigen groups of alternate phrases having a similar most likely meaning from the knowledge database. The alternate phrases are different permutations of the string of words. The method further includes determining a dominant sentiment the other entigen groups and generating an updated clarifying entigen group based on the sentiment.

Abstract: A method executed by a computing device includes determining to extend knowledge within a knowledge database for an object represented by linked entigens of an entigen group based on a deficiency of the entigen group. The method further includes determining a set of identigens for each word of a phrase associated with the object to produce sets of identigens. The method further includes interpreting the sets of identigens to determine a most likely meaning interpretation of the phrase and produce a new entigen group. The method further includes updating the entigen group utilizing the new entigen group to produce a curated entigen group such that a deficiency of the entigen group is resolved providing more accurate and more complete knowledge of the object.

Abstract: A system (20) and method for printing on clear polymeric film web (24) are disclosed. A first stationary inkjet print unit (44, 60, 70, 82) has first ejection nozzles that span a width of the clear polymeric film web and a second stationary inkjet print unit (44, 60, 70, 82) has second ejection nozzles that span the width of the clear polymeric film web. A web transport conveys the clear polymeric film web past the stationary inkjet print units. First and second print controllers operate the first and second and stationary inkjet print units to deposit drops of a first and a second material on the clear polymeric film web at a first and a second resolution, respectively. In addition, dimensions and position of a page element to be printed on the clear polymeric film web are adjusted to compensate for distortion that may occur to the printed page element due to shrinking of the clear polymeric film web.

Abstract: A portable cooler container with active temperature control includes a double-walled insulated container body with a chamber to receive and hold temperature sensitive products. A control system is at least partially disposed between an outer wall and an inner wall of the container body. An electronic display screen on one of the lid and the container body configured to display shipping address information for the portable cooler container.

Abstract: A glass manufacturing apparatus includes a forming apparatus defining a travel path extending in a travel direction. The forming apparatus conveys a ribbon of glass-forming material along the travel path in the travel direction of the forming apparatus. The glass manufacturing apparatus includes a cooling tube extending substantially parallel to the travel path and extending across the travel direction. The cooling tube includes a plurality of orifices spaced apart along the cooling tube and facing the travel path. Methods of manufacturing glass can comprise flowing a coolant from an outlet of a conduit in a direction toward a target location of a flowing ribbon of molten material. Methods can also include changing a phase of the coolant while the coolant is flowing towards the target location. The change in phase can cool the target location.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable media for utilizes a collaboration application to provide data beneficial to the authentication of the user. The present application discloses receiving at least one item of personal identifying information for a user from a primary multi-factor authentication device. The present application further discloses receiving at least one item of personal identifying information for a user from a conferencing service in which the user is engaged in a conference. The present application also discloses determining whether to authenticate the user based on the items of personal identifying information from the primary multi-factor authentication device and from the conferencing service.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable media for utilizes a collaboration application to provide data beneficial to the authentication of the user. The present application discloses receiving at least one item of personal identifying information for a user from a primary multi-factor authentication device. The present application further discloses receiving at least one item of personal identifying information for a user from a conferencing service in which the user is engaged in a conference. The present application also discloses determining whether to authenticate the user based on the items of personal identifying information from the primary multi-factor authentication device and from the conferencing service.

Abstract: A method includes detecting an incomplete entigen group within a knowledge database. The incomplete entigen group includes entigens and one or more entigen relationships between at least some of the entigens. The incomplete entigen group represents knowledge of a topic. The method further includes obtaining additive content for the topic based on the incomplete entigen group and generating an additive entigen group based on the additive content. The method further includes updating the incomplete entigen group utilizing the additive entigen group to produce an updated entigen group. The method further includes indicating that the updated entigen group has an un-curated status when the additive entigen group conflicts with the incomplete entigen group.

Abstract: A method executed by a computing device includes determining a set of identigens for each phrase word of a phrase to produce sets of identigens. A set of identigens of the sets of identigens represents one or more different meanings of a phrase word of the phrase. The method further includes obtaining sensor information for one or more phrase words of the phrase. The method further includes selecting an identigen of a first set of identigens based on the sensor information to produce a first identigen selection for the first set of identigens having a selected meaning of one or more different meanings of the first phrase word. The method further includes interpreting remaining sets of identigens of the sets of identigens to produce an entigen group so that the entigen group represents a most likely meaning interpretation of the phrase.

Abstract: A method executed by a computing device includes determining a set of identigens for each query word of a query to produce sets of identigens. A set of identigens of the sets of identigens represents one or more different meanings of a query word of the query. The method further includes determining that a first query word is associated with a first query command. When selecting the first query command, the method further includes interpreting remaining sets of identigens to produce a query entigen group that represents a most likely meaning interpretation of remaining query words. The method further includes accessing a knowledge database utilizing the query entigen group to obtain entigen information and outputting a response based on the entigen information and the first query command.

Abstract: A method performed by a computing device includes determining a set of identigens for each word of words of a subjective query to produce sets of identigens. The method further includes interpreting, using identigen pairing rules of a knowledge database, the sets of identigens to determine a most likely meaning interpretation of the subjective query and produce a query entigen group that includes query entigens. The method further includes identifying one or more characteristic entigen categories for a subjective category entigen of the query entigen group. The method further includes recovering a set of response entigens for the subjective query from the knowledge database utilizing the query entigen group and based on the one or more characteristic entigen categories. The set of response entigens provides an answer for the subjective query.

Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.