Abstract: A method of preplanning for guided medical procedures includes obtaining a first 3D diagnostic dataset for a region of interest of a subject. This first dataset can be a non-stereotactic dataset and provide sufficient contrast to identify target tissue in the region of interest. A treatment preplan is developed to treat the target tissue using the first dataset exclusive of stereotactic data. The treatment preplan includes placement locations for a plurality of initial radiation beams and their respective dose intensities. A second, stereotactic 3D dataset can be obtained for the region of interest. A registered dataset can then be created by registering the first dataset to the second dataset. The treatment preplan can be modified using data associated with the registering step to generate a stereotactic treatment plan including a plurality of radiation treatment beams with respective placement positions based on the registered dataset to treat the target tissue.

Abstract: Devices, methods and systems for frameless guidance of image-based medical procedures such as stereotactic radiotherapy and surgery. Devices including custom fitting subject-specific articles include contoured surfaces that provide spatial reference to the location of target regions within the subject. The devices are attached exclusive of fasteners anchored to the tissue of the subject and reside on the front of a head of the subject when attached. The devices and articles can be fabricated using computer-directed fabrication technology.