Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.

Abstract: Evaluating fraud risk in a transaction between consumer and a merchant over a network is disclosed. The merchant requests service over the network using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned to the merchant. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used to examine numerous factors to calculate fraud risk. A risk score is generated and compared to the merchant's specified risk threshold. The result is returned to the merchant for order disposition.

Abstract: Evaluating fraud risk in a transaction between consumer and a merchant over a network is disclosed. The merchant requests service over the network using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned to the merchant. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used to examine numerous factors to calculate fraud risk. A risk score is generated and compared to the merchant's specified risk threshold. The result is returned to the merchant for order disposition.

Abstract: A technique for evaluating fraud risk in e-commerce transactions between consumer and a merchant is disclosed. The merchant requests service from the system using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used. The system performs analysis including data integrity checks and correlation analyses based on characteristics of the transaction. Other analysis includes comparison of the current transaction against known fraudulent transactions, and a search of a transaction history database to identify abnormal patterns, name and address changes, and defrauders.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.

Abstract: A technique for evaluating fraud risk in e-commerce transactions between consumer and a merchant is disclosed. The merchant requests service from the system using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used. The system performs analysis including data integrity checks and correlation analyses based on characteristics of the transaction. Other analysis includes comparison of the current transaction against known fraudulent transactions, and a search of a transaction history database to identify abnormal patterns, name and address changes, and defrauders.

Abstract: A method and system for evaluating fraud risk in an electronic commerce transaction between consumer and a merchant over a network is disclosed. The merchant requests service from the system over the network using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned to the merchant. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used to examine numerous factors to calculate fraud risk. The fraud screening system performs analysis that utilizes data elements submitted with the order, and includes data integrity checks and correlation analyses based on the characteristics of the transaction.

Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.

Abstract: A catalyst for oxidation reactions, particularly the oxidation of ammonia comprises oxides of (a) at least one element A selected from rare earths and yttrium, and (b) cobalt and element A being in such proportions that the element A to cobalt atomic ratio is in the range 0.8 to 1.2, at least some of said cobalt and element A oxides being present as a mixed oxide phase with less than 25% of the cobalt (by atoms) being present as free cobalt oxides, is disclosed. The catalyst may be supported on a secondary support in the form of an alkali-free alumina or lanthana wash coat on a primary support in the form of a mesh, gauze, pad, or monolith formed from a high temperature iron/aluminum alloy or a mesh, gauze, pad, monolith, or foam of a ceramic material.

Abstract: Low overbased alkaline earth metal alkylaryl sulfonate having a Total Base Number of from about 2 to about 30, a dialkylate content of 0% to about 25% and a monoalkylate content of about 75% to about 90% or more, wherein the alkylaryl moiety is alkyltoluene or alkylbenzene in which the alkyl group is a C15-C21 branched chain alkyl group derived from a propylene oligomer are useful as lubricating oil additives.

Abstract: Low overbased alkaline earth metal alkylaryl sulfonate having a Total Base Number of from about 2 to about 30, a dialkylate content of 0% to about 25% and a monoalkylate content of about 75% to about 90% or more, wherein the alkylaryl moiety is alkyltoluene or alkylbenzene in which the alkyl group is a C15-C21 branched chain alkyl group derived from a propylene oligomer are useful as lubricating oil additives.

Abstract: An exothermic oxidation process wherein a rotating bed containing a variable oxidation state material is cycled through a succession of stages including an oxidative regeneration stage including a step wherein an oxidising fluid is passed through the bed, and a reaction stage wherein feedstock is passed through the bed, whereby said feedstock is oxidised to give products stream with the concurrent reduction of the convertible material to its lower oxidation state. The process can further include a stage wherein cooling fluid is passed through the bed.

Abstract: Mixture of alkyl phenyl sulfonates of alkaline earth metals having: (a) from 20% to 70% by weight of a linear mono alkyl phenyl sulfonate in which the linear mono alkyl substituent contains from 14 to 40 carbon atoms, preferably from 20 to 24 carbon atoms, and the mole % of the phenyl sulfonate radical fixed on position 1 or 2 of the linear alkyl chain is between 10% and 25%, preferably between 13% and 20%, and (b) from 30% to 80% by weight of a branched mono alkyl phenyl sulfonate in which the branched mono alkyl substituent contains from 14 to 18 carbon atoms.

Abstract: Shaped particles, comprising a calcium aluminate cement and at least one oxide of a Group VIII metal M selected from nickel and cobalt, said particles containing 10 to 70% by weight of said Group VIII metal oxide (expressed as the divalent oxide, MO) and having a porosity in the range 25 to 50%, in which at least 30% of the pore volume is in the form of pores of size in the range 15 to 35 nm and less than 40% of the pore volume is in the form of pores of diameter greater than 35 nm. These particles are used to catalytically decompose oxidizing agents including hypohalites.

Abstract: A catalytic hydrogenation process comprising contacting a catalyst effective to promote a hydrogenation reaction with a feed stream comprising gaseous hydrogen and an unsaturated hydrocarbon thereby hydrogenating at least some of said unsaturated hydrocarbon, said catalyst being prepared from a precursor comprising a calcium aluminate cement and at least one oxide of a metal selected from nickel and cobalt by reduction of said metal oxide, and wherein said precursor contains 10 to 70% by weight of said metal oxide (expressed as the divalent oxide, MO) and has a porosity in the range 25 to 50%, in which at least 30% of the pore volume is in the form of pores of size in the range 15 to 35 nm and less than 40% of the pore volume is in the form of pores of diameter greater than 35 nm.

Abstract: Shaped particles suitable for use as a catalyst, or precursor thereto, particularly for the decomposition of hypohalite ions in aqueous solution, comprising a calcium aluminate cement and at least one oxide of a Group VIII metal M selected from nickel and cobalt, said particles containing 10 to 70% by weight of said Group VIII metal oxide (expressed as the divalent oxide, MO) and having a porosity in the range 25 to 50%, in which at least 30% of the pore volume is in the form of pores of size in the range 15 to 35 nm and less than 40% of the pore volume is in the form of pores of diameter greater than 35 nm.

Abstract: A catalyst system and process for the selective hydrogenation of aliphatic unsaturation in copolymers containing aromatic groups for example styrene-butadiene copolyers, the catalyst system comprising palladium supported on non-porous carbon black poisoned by a Lewis base containing nitrogen, phosphorus or sulphur moiety.

Abstract: A three dimensional interstitial catalyst support and a catalyst system comprising the support for use in (especially pressure-sensitive) surface reactions involving disturbed fluid flow, especially trickle feed three phase reactions such as the hydrogenation of crotonaldehydes or butyraldehyde. The support comprises a three dimensional self-supporting form-stable interstitial structure composed of five or more superimposed intermeshing layers of knitted cloth and the volume of the interstices in the structure is from 60 to 98 (preferably at least 85) % of the volume of the structure. The combination of the use of intermeshing knitted wire, form-stability and an open structure allows disturbances comprising components of motion transverse to the general flow of the fluid through the support to be imparted by the catalyst system with less risk of blockages, flooding or damage by attrition and hence less need to increase pressure during a reaction which is undesirable in pressure sensitive reactions.

Abstract: Automated machine for the continuous bias cutting of an elongated tube of material, such as tubular knitted fabric, into a plurality of individual strips, and winding the strips into a plurality of rolls. The tubular material is advanced axially at a uniform rate from a supply to a cutting and rolling section by a plurality of skewable rotatable cylinders acting as a positive feeding means. As the tubular material is withdrawn from the supply, it passes over a spreader which opens and tensions it. The skewed cylinders cause the tube to rotate about its axis as it advances. Control means are utilized to adjust automatically the skew angles of the cylinders, to increase or decrease the rate of advance of the tube, to compensate for variations inherent in the material which affect its rate of feed. Control means also are utilized to adjust automatically the tension exerted by the spreader, to correlate such tension with the rate of advance as determined by the skew angles of the cylinders.