Patents by Inventor Frank Koehn

Frank Koehn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytotoxic macrolides and methods of use
    Patent number: 5684036
    Abstract: Novel macrolide compounds, including Lasonolide A and Lasonolide B, have been isolated from a marine sponge. These compounds, analogs, derivatives, or isomers of these compounds, and compositions comprising the compounds or its derivatives, are useful as antitumor agents and as biochemical tools.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 4, 1997
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Paul A. Horton, Frank Koehn, Ross E. Longley, Oliver J. McConnell, Shirley A. Pomponi
  • Cytotoxic macrolides and methods of use
    Patent number: 5478861
    Abstract: A novel macrolide compound, lasonolide A, has been isolated from a marine sponge. This compound, derivatives of the compound, and compositions comprising the compound or its derivatives, are useful as antitumor agents and as biochemical tools.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: December 26, 1995
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Paul A. Horton, Frank Koehn, Ross E. Longley, Oliver J. McConnell, Shirley A. Pomponi
  • Novel antiviral and anti-leukemia terpene hydroquinones and methods of use
    Patent number: 5204367
    Abstract: Novel terpene hydroquinones have been isolated from the marine sponge Strongylophora hartmanii. These compounds have been found to have antiviral and anti-leukemia activity. Thus, these compounds, and derivatives thereof, can be used to treat human and animal leukemia as well as viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.
    Type: Grant
    Filed: December 5, 1991
    Date of Patent: April 20, 1993
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Amy E. Wright, Sue S. Cross, Neal S. Burres, Frank Koehn
  • Novel antiviral terpene hydroquinones and methods of use
    Patent number: 5091412
    Abstract: Novel terpene hydroquinones have been isolated from the marine sponge Stronglophora hartmanii. These compounds have been found to have antiviral activity. Thus, these compounds, and derivatives thereof, can be used to treat viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: February 25, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Amy S. Wright, Sue S. Cross, Neal S. Burres, Frank Koehn
  • Biologically active compounds from blue-green algae
    Patent number: 5091368
    Abstract: Novel bioactive compounds have been isolated from blue-green alga. These compounds have been found to have antitumor, antiviral, and immunomodulatory properties. Thus, these compounds, and derivatives thereof, can be used to treat human and animal tumors, inhibit viral growth, and provide immunomodulatory activity.
    Type: Grant
    Filed: August 8, 1990
    Date of Patent: February 25, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Frank Koehn, Sue S. Cross, Ross E. Longley
  • Sterol disulfates and methods of use
    Patent number: 5079239
    Abstract: Novel sterol disulfates have been isolated from the marine sponge Petrosia weinbergii. These compounds, and derivatives thereof, are useful antiviral compounds. One of these compounds is active against the AIDS virus and exhibits immunosuppressive activity.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: January 7, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: H. Howard Sun, Sue S. Cross, Frank Koehn, Malika Gunasekera
  • Novel antiviral and antitumor terpene hydroquinones and methods of use
    Patent number: 5051519
    Abstract: Novel terpene hydroquinones have been isolated from the marine sponge Strongylophora hartmanii. These compounds have been found to have antiviral and antitumor activity. Thus, these compounds, and derivatives thereof, can be used to treat human and animal tumors as well as viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: September 24, 1991
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Amy E. Wright, Sue S. Cross, Neal Burres, Frank Koehn
  • Antiviral compositions derived from marine sponge epipolasis reiswigi and their methods of use
    Patent number: 4935439
    Abstract: This invention relates to antiviral organic compositions and derivatives thereof; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are derived from marine sponges of the genus Epipolasis.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: June 19, 1990
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Yoel Kashman, Shulamit Hirsch, Sue S. Cross, Frank Koehn