Patents by Inventor Frank Kroner

Frank Kroner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ANTI-TROPONINT ANTIBODIES
    Publication number: 20220185874
    Abstract: The present invention relates to an improved variant monoclonal antibody binding to cardiac troponin T and having a better KD than the parent monoclonal antibody 11-7
    Type: Application
    Filed: February 8, 2022
    Publication date: June 16, 2022
    Inventors: Sarah LIEDKE, Frank KRONER, Michael SCHRAEML
  • NOVEL ANTI-THYMIDINE KINASE ANTIBODIES
    Publication number: 20210061924
    Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.
    Type: Application
    Filed: October 13, 2020
    Publication date: March 4, 2021
    Inventors: Hartmut Duefel, Alfred Engel, Frank Kroner, Thomas Meier, Sandra Rutz, Michael Schraeml, Gloria Tabares, Ulrike Kurtkaya, Boris Pinchuk, Christina Zimmermann
  • METHOD FOR AFFINITY MATURATION OF ANTIBODIES
    Publication number: 20210009993
    Abstract: The present invention relates to a novel method of generating libraries of polynucleotides encoding a framework region and at least one adjacent complementarity determining region (CDR) of an antibody of interest. These libraries are suitable for use in affinity maturation procedures in order to obtain maturated antibodies with improved characteristics compared to the parent antibody.
    Type: Application
    Filed: September 9, 2020
    Publication date: January 14, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Frank Kroner, Michael Schraeml, Sarah Liedke
  • NOVEL ANTI-TROPONIN T ANTIBODIES
    Publication number: 20210009668
    Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB.
    Type: Application
    Filed: September 9, 2020
    Publication date: January 14, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Frank Kroner, Michael Schraeml, Sarah Liedke
  • NUCLEIC ACIDS ENCODING CHIMERIC POLYPEPTIDES FOR LIBRARY SCREENING
    Publication number: 20190292535
    Abstract: The present disclosure is directed to a library of chimeric polypeptides comprising one or more fragments from the peptidyl-prolyl cis/trans isomerase or FKBP family displaying one or more polypeptides on one or more FKBP members and its use in methods for the screening and selection of constrained peptide surrogates exhibiting binding activity versus predetermined target molecules.
    Type: Application
    Filed: November 8, 2012
    Publication date: September 26, 2019
    Inventors: David Casagolda Vallribera, Frank Kroner, Michael Schraeml
  • SlyD FKBP domain specific antibodies
    Patent number: 10414818
    Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: September 17, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Michael Schraeml, David Casagolda Vallribera, Frank Kroner
  • Anti-HER3 antibodies binding to the beta-hairpin of HER3
    Patent number: 9783611
    Abstract: The invention relates to specific anti-HER3 antibodies, that bind to the beta-hairpin of HER3, their preparation and use as medicament.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 10, 2017
    Assignee: Hoffman-La Roche Inc.
    Inventors: Birgit Bossenmaier, Richard Buick, Michael Gerg, Frank Kroner, Gerhard Niederfellner, Carmen Peess, Michael Schraeml
  • THERMUS THERMOPHILUS SLYD FKBP DOMAIN SPECIFIC ANTIBODIES
    Publication number: 20160237144
    Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
    Type: Application
    Filed: September 22, 2014
    Publication date: August 18, 2016
    Inventors: Michael Schraeml, David Casagolda Vallribera, Frank Kroner
  • ANTI-HER3 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3
    Publication number: 20160002338
    Abstract: The invention relates to specific anti-HER3 antibodies, that bind to the beta-hairpin of HER3, their preparation and use as medicament.
    Type: Application
    Filed: May 12, 2015
    Publication date: January 7, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Birgit Bossenmaier, Richard Buick, Michael Gerg, Frank Kroner, Gerhard Niederfellner, Carmen Peess, Michael Schraeml