Patents by Inventor Frank L. Brodie

Frank L. Brodie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11844724
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: December 19, 2023
    Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans Affairs
    Inventors: Robert H. Grubbs, Marshall L Stoller, Ying Han, Frank L. Brodie
  • Patent number: 11471326
    Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 18, 2022
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lihong Wang, Frank L. Brodie, Yuecheng Shen, Yan Liu, Haowen Ruan
  • Publication number: 20220040000
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Applicants: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans Affairs
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
  • Publication number: 20210353406
    Abstract: A method of using an implantable artificial intraocular lens capsule to provide accommodative functionality through forward backward movement. The implantable artificial capsule has a ring with a central opening to accommodate an intraocular lens and at least three haptic arms extending from the ring. Visual accommodation is accomplished by forward or backward motion of the artificial intraocular lens which is made possible by the flexibility or stimuli induced shape change of the haptic arms. Stimuli include (i) mechanical forces acting on the haptic arms for example by the ciliary muscle, (ii) gravitational forces acting on the artificial intraocular lens, (iii) forces acting indirectly on the haptics arms or (iv) external forces including electrical or electromagnetic delivered via the externalized haptics.
    Type: Application
    Filed: October 22, 2019
    Publication date: November 18, 2021
    Inventors: Frank L. BRODIE, Stephen D. MCLEOD
  • Patent number: 11166846
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: November 9, 2021
    Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans Affairs
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
  • Patent number: 11170625
    Abstract: A position sensing system comprises a position sensor having an accelerometer and a gyroscope, an alarm, and a controller configured to receive data from the position sensor and activate the alarm according to alarm management instructions stored in a memory. In some embodiments, the alarm instructions include a snooze option to allow the user/patient to temporarily deactivate the alarm. The controller is communicably linked to a remote display device configured to display the orientation of the user's body part.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 9, 2021
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert H. Grubbs, Hyuck Choo, Frank L. Brodie
  • Publication number: 20210315687
    Abstract: An implantable artificial capsule and a method of implantation are provided. The implantable artificial capsule has a ring with a central opening to accommodate an intraocular lens and at least three haptic arms extending substantially orthogonal from the outer surface of the ring. Each arm has transcleral anchors for sutureless scleral fixation. Upon implantation of the implantable artificial capsule the arms are externalized trans-sclerally and atraumatically. The arms sit subconjunctivally. The implantable artificial capsule does not have any sutures for fixation and is suturelessly implanted in an eye, which is a major advantage as it significantly reduces complications during surgery and recovery.
    Type: Application
    Filed: October 13, 2019
    Publication date: October 14, 2021
    Inventors: Frank L. Brodie, David Myung, David Buickians
  • Patent number: 10827950
    Abstract: A position sensing apparatus includes a position sensor, a voltage/current detector, and an alarm. The position sensor is coupled to the body part and includes a capsule, and first and second electrodes. The capsule has an interior volume configured to contain a liquid with a first density, and a contact member having a second density different from the first density. The first and second electrodes are fixed to the capsule to define a sensor meridian that is coupled to a tilt angle of the body part, with each electrode having a distal portion in the interior volume of the capsule, and the distal portions being configured to form a circuit with the liquid or the contact member. The voltage/current detector is configured to detect a change in a state of the circuit, and the alarm is configured to respond to the voltage/current detector.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 10, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Hyuck Choo, Frank L. Brodie, Robert H. Grubbs
  • Publication number: 20200214890
    Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 9, 2020
    Inventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
  • Publication number: 20200051415
    Abstract: A position sensing system comprises a position sensor having an accelerometer and a gyroscope, an alarm, and a controller configured to receive data from the position sensor and activate the alarm according to alarm management instructions stored in a memory. In some embodiments, the alarm instructions include a snooze option to allow the user/patient to temporarily deactivate the alarm. The controller is communicably linked to a remote display device configured to display the orientation of the user's body part.
    Type: Application
    Filed: May 20, 2019
    Publication date: February 13, 2020
    Inventors: Robert H. Grubbs, Hyuck Choo, Frank L. Brodie
  • Publication number: 20190125583
    Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Applicant: California Institute of Technology
    Inventors: Lihong Wang, Frank L. Brodie, Yuecheng Shen, Yan Liu, Haowen Ruan
  • Publication number: 20160256081
    Abstract: A position sensing apparatus includes a position sensor, a voltage/current detector, and an alarm. The position sensor is coupled to the body part and includes a capsule, and first and second electrodes. The capsule has an interior volume configured to contain a liquid with a first density, and a contact member having a second density different from the first density. The first and second electrodes are fixed to the capsule to define a sensor meridian that is coupled to a tilt angle of the body part, with each electrode having a distal portion in the interior volume of the capsule, and the distal portions being configured to form a circuit with the liquid or the contact member. The voltage/current detector is configured to detect a change in a state of the circuit, and the alarm is configured to respond to the voltage/current detector.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Inventors: Hyuck Choo, Frank L. Brodie, Robert H. Grubbs