Patents by Inventor Frank L. Schwartz

Frank L. Schwartz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention and treatment of non-alcoholic fatty liver disease
    Patent number: 10392381
    Abstract: Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. Methods for inhibiting excessive accumulation of fat in liver tissue. The methods include administering to the subject or contacting the liver tissue with a therapeutically effective amount of at least one compound of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof. The pharmaceutical composition includes at least one compound of the General Formula (I) or the General Formula (II) for administration to a subject for the prevention or treatment of non-alcoholic fatty liver disease.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: August 27, 2019
    Assignee: Ohio University
    Inventors: Kelly D. McCall, Frank L. Schwartz, Douglas J. Goetz
  • Prevention and treatment of non-alcoholic fatty liver disease
    Patent number: 9750723
    Abstract: Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. The methods include administering a therapeutically effective amount of phenylmethimazole, methimazole derivatives, and/or tautomeric cyclic thiones to the subject. The pharmaceutical composition includes phenylmethimazole, methimazole derivatives, and/or tautomeric cyclic thiones formulated for administration to a subject for the prevention or treatment of non-alcoholic fatty liver disease.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: September 5, 2017
    Assignee: Ohio University
    Inventors: Kelly D. McCall, Frank L. Schwartz, Douglas J. Goetz, Ramiro Malgor
  • METHODS AND COMPOSITIONS TO MODIFY GSK-3 ACTIVITY
    Publication number: 20170202818
    Abstract: Methods for modulating GSK-3 activity and methods for treating a GSK-3-mediated disorder in a subject in need thereof. The methods include contacting a cell expressing GSK-3 with or administering to the subject in need a therapeutically effective amount of one or more compounds of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof.
    Type: Application
    Filed: May 6, 2015
    Publication date: July 20, 2017
    Applicant: Ohio University
    Inventors: Douglas Goetz, Kelly D. McCall, Stephen C. Bergmeier, Frank L. Schwartz, Pooja Bhatt, Sudhir Deosarkar
  • PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Publication number: 20170196845
    Abstract: Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. Methods for inhibiting excessive accumulation of fat in liver tissue. The methods include administering to the subject or contacting the liver tissue with a therapeutically effective amount of at least one compound of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof. The pharmaceutical composition includes at least one compound of the General Formula (I) or the General Formula (II) for administration to a subject for the prevention or treatment of non-alcoholic fatty liver disease.
    Type: Application
    Filed: May 6, 2015
    Publication date: July 13, 2017
    Applicant: Ohio University
    Inventors: Kelly D. McCall, Frank L. Schwartz, Douglas J. Goetz
  • PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Publication number: 20160256439
    Abstract: Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. The methods include administering a therapeutically effective amount of phenylmethimazole, methimazole derivatives, and/or tautomeric cyclic thiones to the subject. The pharmaceutical composition includes phenylmethimazole, methimazole derivatives, and/or tautomeric cyclic thiones formulated for administration to a subject for the prevention or treatment of non-alcoholic fatty liver disease.
    Type: Application
    Filed: October 31, 2014
    Publication date: September 8, 2016
    Applicant: Ohio University
    Inventors: Kelly D. McCall, Frank L. Schwartz, Douglas J. Goetz, Ramiro Malgor