Abstract: The invention relates to a method for the immobilization of biomolecules containing at least one sulfhydryl group, which method comprises contacting a modified metal surface with the biomolecule irradiating the resulting surface with UV radiation in the presence of a photo-initiator, wherein said metal surface is modified with a cross-linker compound comprising a terminal thiol or dithiol group covalently linked to the metal surface, a spacer group, which at the other terminal end is carrying an isolated double or triple bond.

Abstract: The invention relates to a method for the immobilization of biomolecules containing at least one sulfhydryl group, which method comprises contacting a modified metal surface with the biomolecule irradiating the resulting surface with UV radiation in the presence of a photo-initiator, wherein said metal surface is modified with a cross-linker compound comprising a terminal thiol or dithiol group covalently linked to the metal surface, a spacer group, which at the other terminal end is carrying an isolated double or triple bond.

Abstract: The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.

Abstract: The invention relates to compounds, which are suitable for coupling to pharmaceuticals, in particular biopharmaceuticals, in addition to conjugates from the compounds comprising biomolecules or pharmaceutically active substances. The inventive compounds are highly cross-linked and can be formed in a simple manner by using a central cross-linking module. The invention also relates to the use of conjugates as an improved formulation of pharmaceuticals and to the production thereof.

Abstract: The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.

Abstract: The present invention relates to compounds which are suitable for coupling to pharmaceuticals, in particular biopharmaceuticals, and to conjugates composed of the compounds and biomolecules or pharmaceutical active compounds. The compounds according to the invention can be readily formed by means of multicomponent reactions. The invention also relates to the use of the conjugates as an improved formulation of pharmaceuticals, and to their preparation. The invention furthermore provides a laboratory kit for the in-vitro preparation of conjugates which are composed of the compounds according to the invention and pharmaceuticals as well as biotechnological substances, in particular biopharmaceuticals, pharmaceutical active compounds, synthetic molecules or surfaces.

Abstract: The invention concerns combined pharmaceutical preparations which inhibit abnormal growth of tumor cells. The combined preparations comprise as active substances compounds having glutaminase activity in combination with certain antineoplastic agents. The invention concerns in particular combined preparations of compounds having glutaminase activity and cytostatic compounds.

Abstract: The present invention relates to new active carbohydrate containing protecting reagents represented by a carbohydrate central unit, which is attached to a polymer chain at least at one of the hydroxyl groups and to an active linkage group at the anomeric position of the carbohydrate central unit. These new compounds are active carbohydrate containing protecting reagents, glycodendrimers and related hydrophilic oligomers. Further the invention relates to a method for their preparation and their use for production of biologically active molecules, which are modified by these reagents preferred for biotechnological use.