Abstract: Disclosed are methods of treating an ocular disease associated with retinal ischemic injury in a subject comprising administering to the subject a p75NTR modulator, a MSC comprising decreased p75NTR expression or activity or a MSC secretome collected from a MSC comprising decreased p75NTR expression or activity. Disclosed are methods of treating late stage diabetes in a subject comprising administering to the subject in need thereof a p75NTR modulator, a MSC comprising decreased p75NTR expression or activity or a MSC secretome collected from a MSC comprising decreased p75NTR expression or activity.

Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.

Abstract: Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.

Abstract: The present invention provides methods of modulating neurotrophic factor-associated activity, especially CNTF-associated levels and activity, using aldose reductase inhibitors. These methods are especially useful in individuals suffering from, or at risk of developing, neurological disorders, including neurodegenerative disorders. The invention also provides methods of palliating neurological disorders and delaying development of neurological disorders using aldose reductase inhibitors.

Abstract: A relational to object mapping system and method permit the transfer and translation of data between a database server having a relational database and an object-oriented apparatus. The object code, such as C++, is translated by a generator object into suitable relational database statements, such as structured query language (SQL). The SQL statement is passed to a query object which executes the statement. In executing the SQL statement, the query object accesses an environment object which supplies the query object with appropriate connection objects for establishing a link between the query object and the database server. The database server supplies the requested data from the relational database to the query object which then stores the data in a storage buffer. The object-oriented apparatus can then access the data from the storage buffer. The query object may activate a transaction object for processing the data before the data is accessed by the object-oriented apparatus.