Patents by Inventor Frank Lovering

Frank Lovering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biaryl Sulfonamides and Methods for Using Same
    Publication number: 20100137298
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Application
    Filed: June 13, 2008
    Publication date: June 3, 2010
    Applicant: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • Biaryl sulfonamides and methods for using same
    Patent number: 7420001
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: September 2, 2008
    Assignee: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase
    Publication number: 20060211730
    Abstract: This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-?, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.
    Type: Application
    Filed: March 16, 2006
    Publication date: September 21, 2006
    Applicant: Wyeth
    Inventors: Jeremy Levin, Zhong Li, George Diamantidis, Frank Lovering, Weiheng Wang, Jeffrey Condon, Yang-I Lin, Jerauld Skotnicki, Kaapjoo Park
  • Azolylacylguanidines as beta-secretase inhibitors
    Publication number: 20060183790
    Abstract: The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: February 13, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: Derek Cole, Eric Manas, Lee Jennings, Frank Lovering, Joseph Stock, William Moore, John Ellingboe, Jeffrey Condon, Mohani Sukhdeo, Ping Zhou, JunJun Wu, Koi Morris
  • Amino-pyridines as inhibitors of beta-secretase
    Publication number: 20060173049
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 3, 2006
    Applicant: Wyeth
    Inventors: Michael Malamas, William Fobare, William Solvibile, Frank Lovering, Jeffrey Condon, Albert Robichaud
  • Inhibitors of phospholipase enzymes
    Patent number: 6916841
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 12, 2005
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Biaryl sulfonamides and methods for using same
    Publication number: 20050143422
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Application
    Filed: December 1, 2004
    Publication date: June 30, 2005
    Applicant: Wyeth
    Inventors: Jeremy Levin, Thomas Rush, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Wu, Rajeev Hotchandani, Jason Xiang, Xuemei Du, Derek Cole, Steve Tam
  • Inhibitors of phospholipase enzymes
    Patent number: 6828344
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: December 7, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Inhibitors of phospholipase enzymes
    Publication number: 20030153751
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Application
    Filed: May 8, 2002
    Publication date: August 14, 2003
    Applicant: American Home Products Corporation
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf