Patents by Inventor Frank M. Longo

Frank M. Longo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations comprising neurotrophin mimetics
    Patent number: 8916556
    Abstract: Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: December 23, 2014
    Assignees: The University of North Carolina at Chapel Hill, The Regents of The University of California, The United States of America represented by the Department of Vetran Affairs
    Inventors: Frank M. Longo, Stephen M. Massa
  • NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS
    Publication number: 20140296343
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 2, 2014
    Inventors: Frank M. LONGO, Stephen M. MASSA, Sandeep GUPTA
  • METHODS OF FACILITATING NEURAL CELL SURVIVAL USING NON-PEPTIDE AND PEPTIDE BDNF NEUROTROPHIN MIMETICS
    Publication number: 20140200277
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 17, 2014
    Applicants: The University of North Carolina at Chapel Hill, The United States of America as represented by the Department of Veterans Affairs, The Regents of the University of California
    Inventors: Frank M. Longo, Stephen M. Massa
  • NEUROTROPHIN MIMETICS AND USES THEREOF
    Publication number: 20140100224
    Abstract: The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.
    Type: Application
    Filed: June 26, 2013
    Publication date: April 10, 2014
    Applicants: The University of North Carolina at Chapel Hill, U.S. Government represented by the Department of Veterans Affairs, The Regents of the University of California
    Inventors: Frank M. Longo, Stephen M. Massa
  • Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics
    Patent number: 8686045
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: April 1, 2014
    Assignees: The University of North Carolina at Chapel Hill, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Frank M. Longo, Stephen M. Massa
  • CRYSTALLINE FORMS OF NEUROTROPHIN MIMETIC COMPOUNDS AND THEIR SALTS
    Publication number: 20130005731
    Abstract: The present invention includes crystalline forms of 2-amino-3-methyl-N-(2-morpholinoethyl)-pentanamide and crystalline forms of salts and/or solvates of 2-amino-3-methyl-N-(2-morpholinoethyl)-pentanamide. Furthermore, the present invention provides compositions comprising the crystalline forms and therapeutic use of the crystalline forms.
    Type: Application
    Filed: November 12, 2010
    Publication date: January 3, 2013
    Applicant: Pharmatrophix, Inc.
    Inventors: Rajgopal Munigeti, Frank M. Longo
  • NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS
    Publication number: 20120004310
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: January 5, 2012
    Inventors: Frank M. LONGO, Stephen M. Massa, Sandeep Gupta
  • NEUROTROPHIN MIMETICS AND USES THEREOF
    Publication number: 20110230479
    Abstract: The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.
    Type: Application
    Filed: October 22, 2010
    Publication date: September 22, 2011
    Inventors: Frank M. Longo, Stephen M. Massa
  • METHODS OF TREATING MULTIPLE SCLEROSIS USING NEUROTROPHIN MIMETICS
    Publication number: 20110003819
    Abstract: Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.
    Type: Application
    Filed: April 19, 2010
    Publication date: January 6, 2011
    Inventors: Frank M. Longo, Stephen M. Massa
  • PHARMACEUTICAL FORMULATIONS COMPRISING NEUROTROPHIN MIMETICS
    Publication number: 20100267727
    Abstract: Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.
    Type: Application
    Filed: April 19, 2010
    Publication date: October 21, 2010
    Inventors: Frank M. Longo, Stephen M. Massa
  • Methods of facilitating cell survival using neurotrophin mimetics
    Patent number: 7723328
    Abstract: Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: May 25, 2010
    Assignees: The University of North Carolina at Chapel Hill, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Frank M. Longo, Stephen M. Massa
  • Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
    Patent number: 5958875
    Abstract: This invention provides compounds displaying NGF agonist activity, wherein the compounds comprise a multimer of a sequence of amino acid residues or biologically functional equivalents thereof, the sequence being substantially homologous to residues 29-38 of NGF, residues 43-47 of NGF or residues 92-97 of NGF. Preferably, the multimer is a cyclic dimer wherein the monomeric amino acid sequences are linked to each other by disulfide bridges. This invention also provides methods and compositions for the treatment of disorders involving NGF-responsive cells, by administering an effective amount of the multimeric NGF agonists of this invention to an individual suffering from such disorder.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: September 28, 1999
    Assignee: The Regents of the University of California
    Inventors: Frank M. Longo, Marston Manthorpe
  • Nerve growth factor peptides
    Patent number: 5134121
    Abstract: The present invention provides both agonist and antagonist nerve growth factor peptides. The NGF blocking peptides can be used to inhibit the expression of mRNA and their encoded proteins whose expression is stimulated by NGF, such as .beta.-protein precursor and prion proteins, which proteins or their products are associated with neurodegenerative disorders, whereas the NGF agonist peptides can be used to treat neoplastic disorders such as neuroblastomas.
    Type: Grant
    Filed: January 14, 1991
    Date of Patent: July 28, 1992
    Assignee: Regents of the University of California
    Inventors: William C. Mobley, Frank M. Longo, James C. Kauer