Abstract: This application relates to the treatment of lysosomal storage disorders resulting from a deficiency of acid maltase and/or acid ?-glucosidase by administering active barley in comminuted form. Also disclosed are methods of replacing acid maltase and/or acid ?-glucosidase by administering active barley in comminuted form. Further disclosed are compositions for carrying out these methods.

Abstract: This application relates to the treatment of lysosomal storage disorders resulting from a deficiency of acid maltase and/or acid ?-glucosidase by administering active barley in comminuted form. Also disclosed are methods of replacing acid maltase and/or acid ?-glucosidase by administering active barley in comminuted form. Further disclosed are compositions for carrying out these methods.

Abstract: The invention provides methods, compositions and kits for enzyme replacement therapy as well as molecular constructs, cells, tissues and plants suitable for expressing recombinant enzymes. Similarly, the invention provides methods for recombinantly producing and orally administering certain metabolic or lysosomal enzymes such as acid alpha glucosidase (GAA) alone, in a pharmaceutical composition or with an activator protein (AGA). Also, the invention provides methods for treating a glycogen storage disease type II (GSDII) or acid maltase deficiency (AMD) or Pompe disease or Fabry disease.

Abstract: The present invention is directed to heat shock proteins from Mycobacterium leprae as well as their encoding polynucleotides and vectors and host cells containing these polynucleotides. These heat shock proteins and their encoding polynucleotides are useful in detection of Mycobacterium leprae. In addition, the heat shock protein can be used as an adjuvant in a pharmaceutical composition containing an antigen to induce or enhance the immune response against the antigen. Further, the heat shock protein may be used to treat atopic conditions or as a vaccine against Mycobacterium leprae. Alternatively, the heat shock protein can be used to form a fusion protein with an antigen to induce or enhance the immune response against the antigen.