Abstract: A valve rotating device with valve stem seal includes a valve rotating device, with a cylinder head rest and a spring rest intended to bear against a valve spring during operation. The valve rotating device is designed to rotate the spring rest relative to the cylinder head rest during operation. A valve stem seal is attached to the cylinder head rest of the valve rotating device. The valve stem seal being designed to bear against a valve stem and to seal same during rotational and axial movements.

Abstract: A device for managing subscriptions of subscribers stores subscription entries. Each subscription entry includes information indicating data of interest in a first part, and includes subscriber information related to subscribers of the data of interest in a second part. Moreover, a subscription entry of the subscription entries includes in its second part subscriber information related to at least two subscribers of the data of interest indicated by the information in the first part. The device further provides the data of interest indicated by the information in the first part of the subscription entry to the at least two subscribers associated with the subscriber information in the second part.

Abstract: The invention relates to substituted S-alaninate derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.

Abstract: A method for monitoring a working environment of a movable device utilizing a monitoring apparatus, wherein the working environment includes a working area and at least one protected area and the movable device is located within the working area during normal operation of said movable device, where the method includes a user inputting a plurality of convex polytopes into the monitoring apparatus, the convex polytopes corresponding to areas in which the movable device is located during normal operation, determining a convex polytope hull using the monitoring apparatus, the convex polytope hull completely enclosing the multiplicity of convex polytopes, and determining the at least one protected area by calculating a difference from the convex polytope hull and the input using the monitoring apparatus, such that monitoring of the position of the movable device is simplified because the working area can be modeled autonomously.

Abstract: A device for managing subscriptions of subscribers stores subscription entries. Each subscription entry includes information indicating data of interest in a first part, and includes subscriber information related to subscribers of the data of interest in a second part. Moreover, a subscription entry of the subscription entries includes in its second part subscriber information related to at least two subscribers of the data of interest indicated by the information in the first part. The device further provides the data of interest indicated by the information in the first part of the subscription entry to the at least two subscribers associated with the subscriber information in the second part.

Abstract: A method for monitoring a working environment of a movable device utilizing a monitoring apparatus, wherein the working environment includes a working area and at least one protected area and the movable device is located within the working area during normal operation of said movable device, where the method includes a user inputting a plurality of convex polytopes into the monitoring apparatus, the convex polytopes corresponding to areas in which the movable device is located during normal operation, determining a convex polytope hull using the monitoring apparatus, the convex polytope hull completely enclosing the multiplicity of convex polytopes, and determining the at least one protected area by calculating a difference from the convex polytope hull and the input using the monitoring apparatus, such that monitoring of the position of the movable device is simplified because the working area can be modeled autonomously.

Abstract: An electrically-powered vehicle assembly for moving on partially electrified railway tracks, the vehicle assembly comprising: i. an electrically powered traction system; ii. a storage and autonomous electric power supply system comprising i. an accumulator unit comprising one or more electricity accumulators, and ii. a super capacitor unit comprising one or more super-capacitive assemblies; iii. a power supply device for supplying external power when available to the traction and the storage and supply system, and iv.

Abstract: The present invention relates to a method for converting a diesel-electric, or diesel hydraulic rail vehicle to an all-electric rail vehicle capable of moving on partially electrified railway tracks, comprising providing the vehicle a storage and autonomous supply electric power system comprising an electric traction unit, if not present in the vehicle prior to the conversion, or if the existing electric traction unit is to be replaced; an accumulator unit comprising one or more electricity accumulators, and a super capacitor unit comprising one or more super-capacitive assemblies; a power supply device for supplying external power when available to the traction and the storage and supply system, and a control and distribution system for distributing electric power between the traction system, the power supply device and the electric power storage and autonomous supply system according to the traction operation and availability of external power.

Abstract: A method controls a folding box machine having a plurality of machining stations and a plurality of control devices for controlling the quality of folding boxes. Each control device controls different quality features of each folding box, and each control device transmits the result of the control to a control unit. Target values are stored in the control unit in order to classify the control results into results which meet the quality standard and results which do not meet the quality standard, and a folding box is discharged depending on an evaluation. The method advantageously reduces waste.

Abstract: A method controls a folding box machine having a plurality of machining stations and a plurality of control devices for controlling the quality of folding boxes. Each control device controls different quality features of each folding box, and each control device transmits the result of the control to a control unit. Target values are stored in the control unit in order to classify the control results into results which meet the quality standard and results which do not meet the quality standard, and a folding box is discharged depending on an evaluation. The method advantageously reduces waste.

Abstract: The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Abstract: The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Abstract: The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Abstract: The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.

Abstract: The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.

Abstract: The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

Abstract: The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.

Abstract: The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.

Abstract: A module for temporarily storing a succession of flat printed products includes a first carrier element train on a first transport element assigned to a first side wall, and a second carrier element train on a second transport element assigned to a second side wall located opposite the first side wall. The transport elements are movable relative to the side walls and correlated with one another, for a form-locking, at least partial support of a printing product loaded into the module. Support for an underside of the loaded printing product is provided by upper sides of first and second carrier elements. Third and fourth carrier elements have respective undersides making form-locking contact with the upper side of the loaded printed product for holding down the underside of the loaded printed product on the upper sides of the first and second carrier elements. A further processing device includes the module.

Abstract: A module for temporarily storing a succession of flat printed products includes a first carrier element train on a first transport element assigned to a first side wall of the module, and a second carrier element train on a second transport element assigned to a second side wall of the module. The second side wall is located opposite the first side wall. The transport elements are movable relative to the side walls and correlated with one another, for a form-locking, at least partial support of a printing product loaded into the module. Support for an underside of the loaded printing product is provided by an upper side of the first carrier element and by an upper side of the second carrier element.