Patents by Inventor Frank Otto
Frank Otto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200317735Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: June 18, 2020Publication date: October 8, 2020Applicant: POLYPHOR AGInventors: Frank Otto GOMBERT, Daniel OBRECHT, Odile SELLIER-KESSLER
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Patent number: 10723765Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: December 27, 2013Date of Patent: July 28, 2020Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Odile Sellier-Kessler
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Patent number: 10519022Abstract: Dispensing assembly comprising a container, containing a pressurized beverage, connected to or provided with a dispense assembly, wherein the dispense assembly comprises an outlet channel closable by a valve body and a chamber between the container and the valve body, which chamber is at least partly closed by a movable and/or deformable wall part connected to the valve body or a valve seat, such that pressurized beverage from the container filling the chamber forces the wall part, into a position biasing the valve body or the valve seat in a position closing the outlet channel and by pushing the wall part the valve body or the valve seat can be forced into a position opening the outlet channel, wherein preferably at least during use there is an open connection between said chamber and a beverage compartment of the container.Type: GrantFiled: April 17, 2019Date of Patent: December 31, 2019Assignee: HEINEKEN SUPPLY CHAIN B.V.Inventors: Bernardus Cornelis Johannes Landman, Jeroen Frank Otto, Rudolf Klaas Van Beelen, Vincent Schats
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Publication number: 20190284038Abstract: Dispensing assembly comprising a container, containing a pressurized beverage, connected to or provided with a dispense assembly, wherein the dispense assembly comprises an outlet channel closable by a valve body and a chamber between the container and the valve body, which chamber is at least partly closed by a movable and/or deformable wall part connected to the valve body or a valve seat, such that pressurized beverage from the container filling the chamber forces the wall part, into a position biasing the valve body or the valve seat in a position closing the outlet channel and by pushing the wall part the valve body or the valve seat can be forced into a position opening the outlet channel, wherein preferably at least during use there is an open connection between said chamber and a beverage compartment of the container.Type: ApplicationFiled: April 17, 2019Publication date: September 19, 2019Inventors: BERNARDUS CORNELIS JOHANNES LANDMAN, JEROEN FRANK OTTO, RUDOLF KLAAS VAN BEELEN, VINCENT SCHATS
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Publication number: 20190284363Abstract: The invention relates to PUR rigid foams which can be obtained by reacting an organic polyisocyanate component B) in a specified viscosity range with a hydrogen-containing component A) which is reactive to isocyanate groups, at least containing a polyol component, water, and optionally stabilizers, catalysts, and other auxiliary agents and additives, in the presence of suitable propellants and to a method for producing same, having the steps of a) providing a mold, b) introducing the foam-forming reaction mixture of component A), the polyisocyanate component B), and propellants T) into the mold, and c) foaming the reaction mixture.Type: ApplicationFiled: November 24, 2017Publication date: September 19, 2019Inventors: Reinhard Albers, Martin Marazita, Frank Otto
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Patent number: 10363284Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8, Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: February 27, 2017Date of Patent: July 30, 2019Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Alexander Lederer, Johann Zimmermann, Christian Oefner
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Patent number: 10308494Abstract: Dispensing assembly (10) comprising a container (1), containing a pressurized beverage, connected to or provided with a dispense assembly, wherein the dispense assembly comprises an outlet channel (12) closable by a valve body (16) and a chamber (14) between the container (1) and the valve body (16), which chamber (14) is at least partly closed by a movable and/or deformable wall part (28) connected to the valve body (16) or a valve seat, such that pressurized beverage from the container filling the chamber forces the wall part (28), into a position biasing the valve body (16) or the valve seat in a position closing the outlet channel (12) and by pushing the wall part the valve body (16) or the valve seat can be forced into a position opening the outlet channel (12), wherein preferably at least during use there is an open connection between said chamber (14) and a beverage compartment of the container (1).Type: GrantFiled: February 3, 2015Date of Patent: June 4, 2019Assignee: HEINEKEN SUPPLY CHAIN B.V.Inventors: Bernardus Cornelis Johannes Landman, Jeroen Frank Otto, Rudolf Klaas Van Beelen, Vincent Schats
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Patent number: 10273267Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues of certain types which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: December 27, 2013Date of Patent: April 30, 2019Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Odile Sellier-Kessler, Alexander Lederer, Christian Ludin, Manuella Schmitt-Billet, Steffen Weinbrenner
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Patent number: 10207911Abstract: Dispensing assembly (10) for beverage from a container (1), comprising an outlet channel (8) for beverage and a valve body (16) operable to open and close said outlet channel (8), wherein the channel defines a direction of flow of the beverage towards an outlet end (13), and wherein the valve body (16) is provided at or near the outlet end (13) of the outlet channel (8) and has a shape with a base (21) facing in a direction against the direction of flow and a tip (22) with an end facing in the direction of flow, wherein the tip, between the base and the end, has an outwardly curved outer surface (24), such that beverage engaging the base (21) can be guided from the base over the outer surface (24) to the end forming a beverage jet when leaving the surface at or near said end.Type: GrantFiled: February 3, 2015Date of Patent: February 19, 2019Assignee: HEINEKEN SUPPLY CHAIN B.V.Inventors: Bernardus Cornelis Johannes Landman, Jeroen Frank Otto, Rudolf Klaas Van Beelen, Vincent Schats
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Publication number: 20170369523Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 8 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have agonizing or antagonizing activity against urotensin II or show inhibition of the STAT6/NCoA-1 interaction and can be used for preventing or treating diseases or disorders related to urotensin II, STAT6 and NCoA-1. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: POLYPHOR AGInventors: John Anthony ROBINSON, Kerstin MÖHLE, Markus SEITZ, Ludovic T. MAILLARD, Roba MOUNME, Frank Otto GOMBERT, Odile SELLIER-KESSLER, Heiko HENZE, Daniel OBRECHT, Christian BISANG, Alexander LEDERER
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Patent number: 9713886Abstract: A cavity between inner and outer walls of an open-box-shaped mold is filled with a polyurethane reaction mixture, containing an isocyanate and an emulsion of an isocyanate-reactive composition with three polyols and a blowing agent, which is cured to a polyurethane containing polymer. The inner and outer wall are a fixed distance from one another and each wall comprises a bottom and sides. The mixture is fed through an inlet in the bottom of the outer wall. Before filling the cavity, the mold is turned downwards so that the mixture foams upwards, filling the cavity. The three polyols are polyether polyol obtained by adding an epoxy to carbohydrates or difunctional or higher-functional alcohols; polyether polyol obtained by adding an epoxy to an aromatic amine; and polyester polyether polyol obtained by adding an epoxy to the esterification product of an aromatic dicarboxylic acid derivative and a difunctional or higher-functional alcohol.Type: GrantFiled: February 20, 2014Date of Patent: July 25, 2017Assignee: Covestro Deutschland AGInventors: Stephanie Vogel, Reinhard Albers, Michael Loof, Frank Otto
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Publication number: 20170174494Abstract: Dispensing assembly (10) comprising a container (1), containing a pressurized beverage, connected to or provided with a dispense assembly, wherein the dispense assembly comprises an outlet channel (12) closable by a valve body (16) and a chamber (14) between the container (1) and the valve body (16), which chamber (14) is at least partly closed by a movable and/or deformable wall part (28) connected to the valve body (16) or a valve seat, such that pressurized beverage from the container filling the chamber forces the wall part (28), into a position biasing the valve body (16) or the valve seat in a position closing the outlet channel (12) and by pushing the wall part the valve body (16) or the valve seat can be forced into a position opening the outlet channel (12), wherein preferably at least during use there is an open connection between said chamber (14) and a beverage compartment of the container (1).Type: ApplicationFiled: February 3, 2015Publication date: June 22, 2017Inventors: Bernardus Cornelis Johannes LANDMAN, Jeroen Frank OTTO, Rudolf Klaas VAN BEELEN, Vincent SCHATS
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Publication number: 20170166432Abstract: Dispensing assembly (10) for beverage from a container (1), comprising an outlet channel (8) for beverage and a valve body (16) operable to open and close said outlet channel (8), wherein the channel defines a direction of flow of the beverage towards an outlet end (13), and wherein the valve body (16) is provided at or near the outlet end (13) of the outlet channel (8) and has a shape with a base (21) facing in a direction against the direction of flow and a tip (22) with an end facing in the direction of flow, wherein the tip, between the base and the end, has an outwardly curved outer surface (24), such that beverage engaging the base (21) can be guided from the base over the outer surface (24) to the end forming a beverage jet when leaving the surface at or near said end.Type: ApplicationFiled: February 3, 2015Publication date: June 15, 2017Inventors: Bernardus Cornelis Johannes LANDMAN, Jeroen Frank OTTO, Rudolf Klaas VAN BEELEN, Vincent SCHATS
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Publication number: 20170165319Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr12-Xaa13Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8, Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicant: POLYPHOR AGInventors: Frank Otto GOMBERT, Daniel OBRECHT, Alexander LEDERER, Johann ZIMMERMANN, Christian OEFNER
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Patent number: 9637520Abstract: Novel template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are ?-amino acid residues connected from the carbonyl (C?O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these ?-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilization of stem cells.Type: GrantFiled: July 9, 2015Date of Patent: May 2, 2017Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Alexander Lederer, Ralf Löwe, Daniel Obrecht, Barbara Romagnoli, Johann Zimmermann, Kalpana Patel
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Patent number: 9617308Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Xaa6-DPro7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Xaa14-Xaa15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa6, Xaa8 Xaa13, Xaa14 and Xaa15 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.Type: GrantFiled: June 6, 2012Date of Patent: April 11, 2017Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Alexander Lederer, Johann Zimmermann, Christian Oefner
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Patent number: 9556231Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Tyr1-His2-Xaa3-Cys4-Ser5-Ala6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Tyr12-Xaa13-Aaa14-DPro15-Pro16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa3, Xaa7, Xaa8, Xaa13 and Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have favorable pharmacological properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: June 5, 2015Date of Patent: January 31, 2017Assignee: POLYPHOR AGInventors: Daniel Obrecht, Frank Otto Gombert, Johann Zimmermann
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Publication number: 20160333053Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues of certain types which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: December 27, 2013Publication date: November 17, 2016Applicant: POLYPHOR AGInventors: Frank Otto GOMBERT, Daniel OBRECHT, Odile SELLIER-KESSLER, Alexander LEDERER, Christian LUDIN, Manuella SCHMITT-BILLET, Steffen WEINBRENNER
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Publication number: 20160318976Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: ApplicationFiled: December 27, 2013Publication date: November 3, 2016Applicant: POLYPHOR AGInventors: Frank Otto GOMBERT, Daniel OBRECHT, Odile SELLIER-KESSLER
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Patent number: 9284352Abstract: ?-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Cys4-Xaa5-Xaa6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa12, Xaa13, Xaa14, Xaa15 and Xaa16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair.Type: GrantFiled: August 22, 2014Date of Patent: March 15, 2016Assignee: POLYPHOR AGInventors: Daniel Obrecht, Frank Otto Gombert, Alexander Lederer, Barbara Romagnoli, Christian Bisang