Patents by Inventor Frank R. Pieper

Frank R. Pieper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lysosomal proteins produced in the milk of transgenic animals
    Publication number: 20040003421
    Abstract: The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6′ position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
    Type: Application
    Filed: January 23, 2003
    Publication date: January 1, 2004
    Applicant: Pharming B.V.
    Inventors: Arnold J.J. Reuser, Ans T. Van der Ploeg, Frank R. Pieper, Martin Ph. Verbeet
  • Lysosomal proteins produced in the milk of transgenic animals
    Publication number: 20030097665
    Abstract: The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6′ position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
    Type: Application
    Filed: March 1, 2000
    Publication date: May 22, 2003
    Inventors: Arnold J.J. Reuser, Ans T. Van der Ploeg, Frank R. Pieper, Martin Ph. Verbeet
  • Lysosomal proteins produced in the milk of transgenic animals
    Patent number: 6118045
    Abstract: The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: September 12, 2000
    Assignees: Pharming B.V., The Universiteit Leiden, Academic Hospital, Eramus Universiteit
    Inventors: Arnold J. J. Reuser, Ans T. Van der Ploeg, Frank R. Pieper, Martin Ph. Verbeet