Patents by Inventor Frank Rösch

Frank Rösch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Labeling precursors and radiotracers for nuclear medicine diagnosis and therapy of prostate cancer-induced bone metastases
    Publication number: 20240100201
    Abstract: The invention relates to a labeling precursor for nuclear medicine diagnostics and theranostics that has the structure with a first PSMA-specific targeting vector TV1, a second targeting vector TV2 having osteoaffinity, a chelator Chel for complexing a radioisotope, and two or three linkers L1, L2 and L3.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 28, 2024
    Applicant: SCV-SpezialChemikalienVertrieb GmbH
    Inventors: Frank RÖSCH, Tilman GRUS
  • Labeling precursors with squaric acid coupling
    Patent number: 11833229
    Abstract: The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111In, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: December 5, 2023
    Assignee: SCV Spezial-Chemikalien-Vertriebs GmbH
    Inventors: Frank Rösch, Lukas Greifenstein, Nils Engelbogen, Ralf Bergmann
  • Smart Drug Delivery System and Pharmaceutical Kit for Dual Nuclear Medical Cytotoxic Theranostics
    Publication number: 20230112958
    Abstract: The invention generally relates to a smart drug delivery system for dual nuclear medical cytotoxic theranostics incorporating either (i) a first compound with the structure CT-L1-Chel-S1-TV or or (ii) a second compound with the structure Chel-S-TV and a third compound with the structure CT-L-TV. In the first, second and third compounds Chel is a radical of a chelating agent for complexing a radioisotope; CT is a radical of a cytotoxic compound; TV is a biological targeting vector; L1 and L are each linkers; S1, S2 and S are each spacers.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 13, 2023
    Applicant: SCV-SpezialChemikalienVertrieb GmbH
    Inventors: Frank RÖSCH, Hanane LAHNIF, Tilmann GRUS
  • LABELING PRECURSORS WITH SQUARIC ACID COUPLING
    Publication number: 20220331456
    Abstract: The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111In, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.
    Type: Application
    Filed: May 16, 2022
    Publication date: October 20, 2022
    Applicant: SCV - SpezialChemikalienVertrieb GmbH
    Inventors: Frank RÖSCH, Lukas GREIFENSTEIN, Nils ENGELBOGEN, Ralf BERGMANN
  • MARKING PRECURSOR WITH SQUARIC ACID COUPLING
    Publication number: 20210369877
    Abstract: The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111ln, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.
    Type: Application
    Filed: October 21, 2019
    Publication date: December 2, 2021
    Applicant: SCV- Spezial Chemikalien Vertrieb GmbH
    Inventors: Frank RÖSCH, Lukas GREIFENSTEIN, Nils ENGELBOGEN, Ralf BERGMANN
  • Conjugated bisphosphonates for the diagnosis and therapy of bone diseases
    Patent number: 10508127
    Abstract: The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator X, said targeting vectors having the structure -L1-R1-L2-R2-L3-R3, wherein R3 contains a bisphosphonate. A pharmaceutical consists of the compound V and a metallic isotope which is complexed with compound V.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 17, 2019
    Assignee: SCV GmbH
    Inventors: Frank Rösch, Marian Meckel
  • Bifunctional chelating agents based on the 1,4-diazepine scaffold (DAZA) for non-invasive molecular imaging
    Patent number: 10130722
    Abstract: A compound for radio metal complexation includes a chelator and one or more biological targeting vectors TV conjugated to said chelator, wherein the chelator has structure (A) or (B) or (C), based on 1,4-diazepine with groups R1, R2, R3, R4, X1, X2, X3. The compound is particularly suited for complexation of radio-isotopic metals, such as 66Ga(III), 67Ga(III) and 68Ga(III).
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: November 20, 2018
    Assignee: Johannes Gutenberg-Universität Mainz
    Inventors: Frank Rösch, Bradley Peter Waldron, David Parker
  • CONJUGATED BISPHOSPHONATES FOR THE DIAGNOSIS AND THERAPY OF BONE DISEASES
    Publication number: 20170327520
    Abstract: The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator X, said targeting vectors having the structure -L1-R1-L2-R2-L3-R3, wherein R3 contains a bisphosphonate. A pharmaceutical consists of the compound V and a metallic isotope which is complexed with compound V.
    Type: Application
    Filed: October 16, 2015
    Publication date: November 16, 2017
    Inventors: Frank Rösch, Marian Meckel
  • BIFUNCTIONAL CHELATING AGENTS BASED ON THE 1,4-DIAZEPINE SCAFFOLD (DAZA) FOR NON-INVASIVE MOLECULAR IMAGING
    Publication number: 20160136309
    Abstract: A compound fur radio metal complexation includes a chelator and one or more biological targeting vectors TV conjugated to said chelator, wherein the chelator has structure (A) or (B)or (C). based on 1,4-diazepine with groups R1, R2, R3, R4, X1, X2, X3. The compound is particularly suited for complexation of radio-isotopic metals, such as 66Ga(III), 67Ga(III) and 68Ga(III).
    Type: Application
    Filed: May 14, 2014
    Publication date: May 19, 2016
    Inventors: Frank RÖSCH, Bradley Peter WALDRON, David PARKER
  • Method and Device for Producing a Radionuclide
    Publication number: 20120325052
    Abstract: The present relates to a method and a device for producing a radionuclide in which an absorption column containing the radionuclide is eluted by means of an eluent in a first flow direction and subsequently in a second, opposite flow direction.
    Type: Application
    Filed: October 12, 2010
    Publication date: December 27, 2012
    Inventors: Frank Rösch, Dimitry Filosofov
  • Method and device for isolating a chemically and radiochemically cleaned Ga-radionuclide and for marking a marking precursor with the Ga-radionuclide
    Patent number: 8147804
    Abstract: The invention relates to initial 68Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon 68Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and radio chemical manner. Subsequently, the 68Ga-radio nuclide is combined with a radio pharmaceutical substance by a marking precursor made of a ligand or a peptide or a protein which is cross-linked in a covalent manner to a ligand.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: April 3, 2012
    Assignee: Johannes Gutenberg-Universität Mainz
    Inventors: Frank Roesch, Dmitry V. Filosofov, Konstantin Zhernosekov, Marc Jennewein