Patents by Inventor Frank R. Sharp

Frank R. Sharp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosis and treatment of Alzheimer's Disease
    Patent number: 11598774
    Abstract: Provided are methods of mitigating, reversing or eliminating in a subject one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain (e.g., olfactory dysfunction as a risk factor of dementia, mild cognitive impairment, Alzheimer's Disease) by detecting and targeting gram negative bacteria in the brain.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 7, 2023
    Assignee: The Regents of the University of California
    Inventors: Xinhua Zhan, Boryana S. Stamova-Kiossepacheva, Frank R. Sharp
  • Methods for diagnosing ischemia
    Patent number: 11421276
    Abstract: This invention provides methods and compositions for diagnosing ischemia, ischemia reference expression profiles, and methods for identifying compounds for treating or preventing ischemia.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: August 23, 2022
    Assignee: The Regents of the University of California
    Inventors: Huichun Xu, Frank R. Sharp
  • METHODS FOR DIAGNOSING ISCHEMIA
    Publication number: 20200157624
    Abstract: This invention provides methods and compositions for diagnosing ischemia, ischemia reference expression profiles, and methods for identifying compounds for treating or preventing ischemia.
    Type: Application
    Filed: June 27, 2019
    Publication date: May 21, 2020
    Applicant: The Regents of the University of California
    Inventors: Huichun Xu, Frank R. Sharp
  • METHODS OF DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20200088724
    Abstract: Provided are methods of mitigating, reversing or eliminating in a subject one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain (e.g., olfactory dysfunction as a risk factor of dementia, mild cognitive impairment, Alzheimer's Disease) by detecting and targeting gram negative bacteria in the brain.
    Type: Application
    Filed: April 23, 2019
    Publication date: March 19, 2020
    Applicant: The Regents of the University of California
    Inventors: Xinhua Zhan, Boryana S. Stamova-Kiossepacheva, Frank R. Sharp
  • GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY
    Publication number: 20110217715
    Abstract: Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD.
    Type: Application
    Filed: October 15, 2009
    Publication date: September 8, 2011
    Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Brenda L. Wong, Frank R. Sharp, Lisa Lit
  • GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY
    Publication number: 20100105054
    Abstract: Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD.
    Type: Application
    Filed: October 14, 2009
    Publication date: April 29, 2010
    Applicants: CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER, THE UNIVERSITY OF CALIFORNIA AT DAVIS
    Inventors: Brenda L. Wong, Frank R. Sharp, Lisa Lit
  • Blood assessment of injury
    Publication number: 20030104393
    Abstract: Methods of injury assessment in an individual include the steps of determining a pattern of expression exhibited by blood cells obtained from an individual and comparing the pattern of expression exhibited by the obtained blood cells to an injury database to assess the injury.
    Type: Application
    Filed: November 28, 2001
    Publication date: June 5, 2003
    Inventors: Frank R. Sharp, Yang Tang, Aigang Lu
  • Stress response imaging by detection of decreased protein synthesis
    Patent number: 5624660
    Abstract: Physiological conditions in a subject which result in a reduction in the rate of protein synthesis are detected by the administration of a labeled amino acid, followed by imaging of the subject's body to detect the uptake of the labeled amino acid in protein synthesis. The method is particularly useful as applied to the detection of ischemic events, focal or global, as well as hypoglycemia and status epilepticus.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 29, 1997
    Assignee: The Regents of the University of California
    Inventor: Frank R. Sharp