Abstract: The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5?-(Tx)GxGxcsasasgscsastscscsTxGxT-3? and 5?-(Gx)TxTxascstsgscscststscsTxTxA-3?, wherein capital letters designate a beta-D-oxy-LNA nucleotide analog, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analog or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighboring nucleotides/LNA nucleotide analogs, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighboring nucleotides/LNA nucleotide analogs, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g.

Abstract: The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5?-(Tx)GxGxcsasasgscsastscscsTxGxT-3? and 5?-(Gx)TxTxascstsgscscststscsTxTxA-3?, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g.

Abstract: A combination support stand and carrying handle apparatus for use with an associated tablet device having a generally rectangular conformation with opposite front and back substantially planar surfaces. The apparatus includes a mounting member, a handle member, and a support stand for holding the associated tablet device on surfaces at selected angles for convenience of use of the tablet device. The carrying handle is grippable by the hand of an associated user. The support stand apparatus and carrying handle apparatus may be provided individually without the other.

Abstract: A grippable support apparatus functions as a combination support stand and carrying handle for portable electronic devices. The apparatus includes a base member, an attachment member for attaching the base member with a rear surface of the table device, and an interface configured to be gripped by the hand of an associated user for carrying the tablet device from place to place. The interface includes first and second interface members configured to engage a ventral side and a dorsal side, respectively, of the hand of the user.

Abstract: A grippable support apparatus functions as a combination support stand and carrying handle for portable electronic devices. The apparatus includes a base member, an attachment member for attaching the base member with a rear surface of the table device, and an interface configured to be gripped by the hand of an associated user for carrying the tablet device from place to place. The interface includes first and second interface members configured to engage a ventral side and a dorsal side, respectively, of the hand of the user.

Abstract: A combination support stand and carrying handle apparatus for use with an associated tablet device having a generally rectangular conformation with opposite front and back substantially planar surfaces. The apparatus includes a mounting member, a handle member, and a support stand for holding the associated tablet device on surfaces at selected angles for convenience of use of the tablet device. The carrying handle is grippable by the hand of an associated user. The support stand apparatus and carrying handle apparatus may be provided individually without the other.

Abstract: The invention regards an audio processing device with at least one encapsulated electronic component mounted and electrically connected to electric leads in a mounting substrate. Further electric components are mounted for connection with the encapsulated electronic component through the substrate and the encapsulation material is moulded onto the substrate. According to the invention at least one metal layer is deposited on a surface part of the encapsulation material. The invention further regards a method for producing an amplifier for an audio device whereby at least one encapsulated electronic component is mounted on, and electrically connected to a PCB and where the encapsulation material is provided to protect the electronic component wherein further a metal layer is generated at least on a surface area of the encapsulation material.

Abstract: It is an object of the invention to provide an adhesive element having an adhesive surface showing adhesive properties for adhering to a substrate wherein at least a part of the surface has been treated, resulting in alteration of the surface properties of the heat treated part of the surface. By heat treatment it is possible to provide an adhesive surface having parts showing different colour, water absorption properties, and/or adhesive properties.

Abstract: The present invention relates to a surface mounted coil (200) for wireless communication. The coil (200) comprises a wire (202) wounded about a core (204) thereby establishing a plurality of windings and having its ends terminated on mounting sections (208) at each end of the core (204). The coil (200) further comprises a shielding layer (212, 300) wound about a central part of the core (204) thereby covering said windings. The shielding layer (212, 300) comprises a shielding pattern and a contact section (214) for connecting to a ground level and to the shielding pattern.

Abstract: The invention concerns a microphone with a membrane. The membrane has a first side which is in fluid contact with the surroundings and a second side which is facing a back chamber, where a barometric relief opening or vent opening is provided between the back chamber and the surroundings. According to the invention control means are provided for controlling the barometric relief opening.

Abstract: The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5?-(Tx)GxGxcsasasgscsastscscsTxGxT-3? and 5?-(Gx)TxTxascstsgscscststscsTxTxA-3?, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g.

Abstract: A method of decreasing the penetration depth of radiation provided to an interface, such as a surface, or a predetermined volume in a means, where the means has a scattering coefficient larger than one tenth of an absorption coefficient thereof so that the radiation not absorbed at the interface or in the volume but transmitted further into the means is at least partly reflected toward the interface/volume. The radiation intensity is higher in the volume and the absorption coefficient may be reduced while retaining the total absorption in the volume. This may be used for all known techniques where radiation is desired absorbed, such as in welding, surface preparation, polymer chemistry, the activation of photo activatable substances etc.

Abstract: The invention concerns a process for generating a feed-through in a semiconductor wafer, which has electric circuitry embedded in a front surface whereby the hole for the feed-through is generated by the combined use of a front side protection layer and a wet KOH etch process etching the hole from the back side of the wafer, where a photomasking process is subsequently used do define the via followed by deposition of the via material.

Abstract: The invention concerns a hearing aid with at least one primary sound to electric converting transducer converting sounds in the environment into electrical signals and a signal processing unit for amplifying the electrical signal according to the needs of the user and an electrical to sound transducer for receiving the amplified electrical signal and delivering a sound signal to the ear wherein at least one further sound to electrical transducer is provided. The said further transducer has a sensitivity to wind noise which is smaller than the sensitivity to wind noise of the primary transducer and further the signal processing unit has means for detecting the level of wind noise in the signal from the primary sound to electric converting transducer. According to the invention also selecting means are provided for selecting the signal to be amplified from either the primary—or the at least one further sound to electrical transducer.

Abstract: A bottom center mounted drawer slide mechanism for a drawer and cabinet. The mechanism is designed to be mounted along the bottom centerline of the drawer. The mechanism includes a cabinet track structure consisting essentially of a substantially C-shaped cross-section, rollers, and mounting tabs; a drawer track with retention dimples and rollers; a mounting plate onto which the drawer mounts; and a mounting unit which mounts onto the cabinet. The rollers of the cabinet track structure and the drawer track allow the drawer to move in and out smoothly and with little need for alignment adjustment.