Abstract: The invention provides anti-variant Fc-region antibodies which specifically bind to an antibody that has the mutation P329G or the mutations P329G/L234A/L235A or the mutations 1253A/H310A/H435A in the Fc-region, and methods of using the same.

Abstract: An electrical connector includes: at least a first housing part and a second housing part, one of the first housing part and the second housing part engaging, at least partially and concentrically, in an other of the first housing part and the second housing part in an engagement region, the first housing part and the second housing part being rotatable relative to one another in the engagement region about an axis of rotation. The first housing part and the second housing part each have a magnetic structure extending, at least in part, circumferentially on an inside or an outside in the engagement region, the respective magnetic structures interacting.

Abstract: A dialysis concentrate container for single-use, comprising a container portion (1, 2) which can be filled with dialysis concentrate and a connecting portion (13, 3) connected thereto for connecting the dialysis concentrate container to a dialysis machine, wherein the connecting portion (13, 3) has laterally spaced fluid connection elements (31) for connecting to a fluid outlet and a fluid inlet of the dialysis machine, wherein the container body (1, 2) is formed as a rigid box, wherein the connecting portion (13, 3) is further arranged at the lower end of the container body, wherein the connecting portion (13, 3) is formed by a plate body which can be clamped into a connecting block of the dialysis machine, and on the underside of which the fluid connecting elements (31) are formed, one of which being connected to a fluid inlet of the container body (1) and the other one being connected to a fluid outlet thereof.

Abstract: A magnetic separation rack made of a plastics material for performing automated magnetic separation processes comprises a base plate in which a matrix of m×n wells is formed, and a comb-like hollow rod plate with a matrix of m×n hollow rods each connected with its upper end to a horizontal carrier plate and having a radially outwardly protruding ring collar on its lower end region. The carrier plate has a recess on the position of placement of each hollow rod, the extension of the recess corresponding at least to the projection of the ring collar onto the carrier plate. Each hollow rod has on its outer circumference a plurality of radial ribs extending along the axis of the hollow rod towards the upper end starting from the ring collar, and their connecting the hollow rod to the carrier plate is in one piece while extending radially through the recess.

Abstract: A dialysis concentrate container for single-use, comprising a container portion (1, 2) which can be filled with dialysis concentrate and a connecting portion (13, 3) connected thereto for connecting the dialysis concentrate container to a dialysis machine, wherein the connecting portion (13, 3) has laterally spaced fluid connection elements (31) for connecting to a fluid outlet and a fluid inlet of the dialysis machine, wherein the container body (1, 2) is formed as a rigid box, wherein the connecting portion (13, 3) is further arranged at the lower end of the container body, wherein the connecting portion (13, 3) is formed by a plate body which can be clamped into a connecting block of the dialysis machine, and on the underside of which the fluid connecting elements (31) are formed, one of which being connected to a fluid inlet of the container body (1) and the other one being connected to a fluid outlet thereof.

Abstract: A cartridge piston has a venting valve and a valve part that is inserted into a front-side recess of the piston, the recess comprising a through opening and a surrounding annular groove. The valve part consists of a central body passing through said through opening and has a projection coacting with a sealing edge and protruding over the back side of the piston. The valve part also consists of a double-walled wall body located in the annular groove and connected to the central body by a front wall, wherein a venting path passes from the piston front side through an air passage into an interspace of the wall body and a filter path formed between an annular wall of the wall body and an annular wall part of the piston provided between said through opening and said groove, and through an annular gap between said wall part and said central body to said sealing edge.

Abstract: A dosing device comprises a housing. The housing has a slot-shaped opening in the axial direction. The respective region of a setting cylinder located inside the housing can be seen from the exterior through the opening. The setting cylinder can be radially rotated or set by way of a setting wheel. Quantitative indications of the discharge volumes for various syringe types at various settings are arranged in columns on the setting cylinder in the form of a table. The cylinder is oriented relative to the window in the housing such that at a given angular setting of the cylinder the correct discharge volume is visible in the window for every syringe type.

Abstract: A dosing device comprises a housing. The housing has a slot-shaped opening in the axial direction. The respective region of a setting cylinder located inside the housing can be seen from the exterior through the opening. The setting cylinder can be radially rotated or set by way of a setting wheel. Quantitative indications of the discharge volumes for various syringe types at various settings are arranged in columns on the setting cylinder in the form of a table. The cylinder is oriented relative to the window in the housing such that at a given angular setting of the cylinder the correct discharge volume is visible in the window for every syringe type.

Abstract: In a mixing system for two-component cartridges having a neck section structure with an inner discharge channel and an outer tubular discharge channel for discharging first and second material components from first and second chambers of the cartridge, the inner discharge channel is provided with pockets extending into the outer discharge channel for dividing the second material flow into second material flow strands and a baffle plate is arranged centrally in front of the inner discharge channel for directing the inner material flow outwardly through the pockets in strands of the inner material component between strands of the outer material component, so that a pre-mixing of the material components occurs already directly at the openings of the discharge channels.

Abstract: A rigid container made of plastics for receiving a solid or liquid concentrate for the preparation of a dialysis fluid for use in a dialysis machine, the container consisting of a base part and a lid part and being equipped with a first connector for feeding and a second connector for draining a liquid and for connecting to a dialysis machine, and being otherwise closed or closable in an airtight manner, is characterized in that the second connector is connected to an outlet line (3), the feeding opening of which is arranged near the bottom of the base part.

Abstract: In a mixing system for two-component cartridges having a neck section structure with an inner discharge channel and an outer tubular discharge channel for discharging first and second material components from first and second chambers of the cartridge, the inner discharge channel is provided with pockets extending into the outer discharge channel for dividing the second material flow into second material flow strands and a baffle plate is arranged centrally in front of the inner discharge channel for directing the inner material flow outwardly through the pockets in strands of the inner material component between strands of the outer material component, so that a pre-mixing of the material components occurs already directly at the openings of the discharge channels.

Abstract: In a two chamber cartridge with chambers arranged axially one after the other, wherein the front chamber in a front part of the cartridge interior is divided by a double wall insert into an outer partial chamber and an inner partial chamber which are both closed at the rear ends by pistons and the rear chamber is formed by a beaker which is inserted into the rear of the cartridge and has a beaker bottom with a pin extending from the beaker bottom though an annular piston closing the beaker, the rear end of the double wall insert abuts the annular piston closing the beaker and the annular piston includes passages leading to gap between the two spaced walls of the double wall insert and the two front partial chambers and the intermediate space are in communication with a mouthpiece space at the front end of the cartridge.

Abstract: In a bicarbonate container for one-time use with a hemodialysis apparatus which container consists of a bottom part with a trough for containing the bicarbonate, a cover for closing the trough and a two-channel plug-in connector for connection to a dialysis apparatus, the bottom part and the top part include flanges which are joined and form therebetween a conduit channel extending from one end of the container where the plug-in connector is disposed to the other end of the container for conducting liquid supplied through one of the plug-in connector channels through the bicarbonate filling of the trough of the container in which the bicarbonate is disposed to the other channel of the plug-in connector.

Abstract: In a bicarbonate container for one-time use with a hemodialysis apparatus which container consists of a bottom part with a trough for containing the bicarbonate, a cover for closing the trough and a two-channel plug-in connector for connection to a dialysis apparatus, the bottom part and the top part include flanges which are joined and form therebetween a conduit channel extending from one end of the container where the plug-in connector is disposed to the other end of the container for conducting liquid supplied through one of the plug-in connector channels through the bicarbonate filling of the trough of the container in which the bicarbonate is disposed to the other channel of the plug-in connector.

Abstract: A cartridge stopper having a valve function, especially for printing ink cartridges made of plastic, includes a valve sleeve that is axially elastic and rests on a mouthpiece neck. The valve sleeve includes a sealing lip that cooperates with a central body, and can move elastically forward (open) when pressure is exerted on the cartridge contents in order to clear a slit opening between the mouthpiece neck and the central body.

Abstract: An apparatus proportions and dispenses at least two different plastic materials such as, two component adhesives or sealants in which the components are stored separately from one another before use and are mixed with one another only for use. The apparatus includes a multichamber cartridge made from injection-molded plastic with at least two cartridge tube wall parts located one inside the other to form at least two chambers that receive one material component each. An end wall part is located at the anterior end of the cartridge tube wall parts on which a mouthpiece for dispensing the plastic material components from the cartridge is formed. Piston elements are inserted in the rear end of the cartridge tube wall parts to express the material components. The end wall part is formed as a separate head piece and the cartridge tube wall parts likewise are formed from two separately manufactured parts. Snap connections are provided to connect the cartridge tube wall parts with the head piece.

Abstract: A stepping motor is used to feed sheet stock to a blank making assembly in a container making process. A translator provides necessary pulses to the stepping motor and is controlled by a counter which is provided with a pulse train indicative of the number of pulses provided the stepping motor. The contents of the counter compensate for the number of pulses necessary to stop the motor which will be produced by the translator. Alternatively, a print registration indicia may be sensed to initiate deceleration of the stepping motor. The indicia is offset a predetermined distance from a point of proper registration in order to compensate for the distance necessary to decelerate the stepping motor.