Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 5-substituted tetrandrine derivatives of formula (I) and a pharmaceutically acceptable adduct, complex and salt thereof, to a process for the preparation of these compounds, pharmaceutical compositions containing such compounds and their use in preparing antineoplastic medicaments.

Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-alkyl- or 2-aromatic-substituted tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When Z?R, said derivative is 2-alkyl-substituted tanshinone I; when Z?Ar, said derivative is 2-aryl-substituted tanshinone I; when Z=Het, said derivative is 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I.

Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel homoharringtonine acylated derivatives of formula (I) and formula (II) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel aminated homoharringtonine derivatives of formula (I) and a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.

Abstract: The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.

Abstract: The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.

Abstract: The invention provides substituted quinoxalines having the general formulas where R1, R2, R3, and R4 are, inter alia, alkyl, aryl, or heteroaryl groups; Z is NH or O; and X is, inter alia, COOH or CONH2. The compounds of the invention have antiviral and immunomodulatory activity and are useful for treating infectious diseases, particularly viral infections.

Abstract: The invention relates to substituted quinoxalines which have antiviral and immunomodulatory activity. The compounds of the invention are useful for treating infectious diseases, particularly viral diseases.

Abstract: Methods for generation of nucleoside libraries are provided in which nucleosides or nucleoside precursors (e.g., a sugar or a base) are coupled to a solid phase and sequentially reacted with various substrates.

Abstract: Methods for forming fastener holes in the construction of fuselage assemblies. The method utilizes a triple gantry drilling system with upper, left and right side gantries, within which are dedicated robotic deployment arms having an automatic tool change system with drill attachment exchangeable with a plurality of tools. Each gantry is capable of translational movement along three different axis, as well as rotational movement about an axis of rotation and axis of pitch, respectively, such that simultaneous drilling about the fuselage can be achieved. The method further includes the incorporation of a vision system with camera to assist mechanics to view the drilling processes and verify structure position.