Abstract: Systems and methods for computation of derivatives of stochastic programs are disclosed. A system having at least one processor is configured for automatically determining a derivative of an expectation of a stochastic program with respect to its input parameters, where the stochastic program includes continuous and discrete sources of randomness.

Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Abstract: A method is provided for providing a software application on a computer unit. The method comprises the following steps: carrying out an AOT compilation of the software application present in the form of source code to generate assembler code from the source code of the software application; obfuscating the assembler code of the software application; posting the obfuscated assembler code of the software application to a software distribution platform; and downloading the obfuscated assembler code to the computer unit. Further, a corresponding computer unit is provided.

Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Abstract: A PKI key pair comprising a private key and a public key is arranged for the end device. The public key is stored at the communication partner. The communication partner is arranged to provide a session key, encrypt data using the session key, encrypt the session key using the public key and convey the encrypted data to the end device. The communication system is further characterized in that it comprises a server system, remote from the mobile end device, in which the private key is stored in a secure environment. For this, the communication partner is furthermore arranged to transmit the encrypted session key to the server system. Moreover, the server system is arranged to decrypt the session key for the end device with the private key and to transmit it in decrypted form to the end device for decrypting the data.

Abstract: A method is provided for providing a software application on a computer unit. The method comprises the following steps: carrying out an AOT compilation of the software application present in the form of source code to generate assembler code from the source code of the software application; obfuscating the assembler code of the software application; posting the obfuscated assembler code of the software application to a software distribution platform; and downloading the obfuscated assembler code to the computer unit. Further, a corresponding computer unit is provided.

Abstract: A method is provided for installing a security-relevant portion of an application made available by an application provider in a security element of a terminal. The terminal requests the application from the application provider and receives the application. Subsequently, the received security-relevant portion of the application is transmitted to a trustworthy instance administrating the security element. The trustworthy instance subsequently installs the security-relevant portion of the application in the security element.

Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Abstract: A method for operating a computer unit having a processor on which a software application can run comprises the steps: upon invoking the software application or upon carrying out a transaction with the software application on the computer unit the step of checking whether the computer unit has been restarted since the last invoking of the software application; carrying out a first form of authentication for starting the software application or for carrying out the transaction with the software application if the computer unit has not been restarted since the last invoking of the software application; and carrying out a second form of authentication for starting the software application or for carrying out the transaction with the software application if the computer unit has been restarted since the last invoking of the software application. Further provided are a correspondingly designed software application as well as a correspondingly designed computer unit.

Abstract: A PKI key pair comprising a private key and a public key is arranged for the end device. The public key is stored at the communication partner. The communication partner is arranged to provide a session key, encrypt data using the session key, encrypt the session key using the public key and convey the encrypted data to the end device. The communication system is further characterized in that it comprises a server system, remote from the mobile end device, in which the private key is stored in a secure environment. For this, the communication partner is furthermore arranged to transmit the encrypted session key to the server system. Moreover, the server system is arranged to decrypt the session key for the end device with the private key and to transmit it in decrypted form to the end device for decrypting the data.

Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.

Abstract: A data sink/data source data transmission device and data terminal device for a circuit-switched and packet-switched network that eliminates the logical separation between applications, which are based on the circuit-switched network (e.g., PSTN, ISDN), and applications, which are based on the packet-switched network, (e.g., Internet). To this end, a data transmission device for transmitting and receiving data into/from the circuit-switched network includes controllable switchover parts. This data transmission device is or can be assigned to a universally useable unit for automatically processing data and for transmitting and receiving data to/from the packet-switched network and is assigned or can be assigned to the at least one data terminal device for transmitting and receiving data into/from the circuit-switched network.

Abstract: A method is provided for installing a security-relevant portion of an application made available by an application provider in a security element of a terminal. The terminal requests the application from the application provider and receives the application. Subsequently, the received security-relevant portion of the application is transmitted to a trustworthy instance administrating the security element. The trustworthy instance subsequently installs the security-relevant portion of the application in the security element.

Abstract: The invention relates to a composite part having a decor skin with a first and a second section, preferably each including leather, and a holding portion, wherein the first and second sections are connected to one another by a seam and a part region of the decor skin is connected to the holding portion. In accordance with the invention, the part region of the decor skin is preferably connected to the holding portion with material continuity in the region of the seam.

Abstract: A profiled retaining section for positioning a seam connecting two decorative layers includes an upper region, a center region and a lower region forming at least one anchor. The upper region is designed as a piping, or in the manner of a piping, for protruding over a visible side of the skins to be positioned. The center region includes two sides to be sewn to the decorative layers. The anchor is designed to be introduced in a groove having a lesser width than the anchor itself and to exert a force on the groove in the lateral direction. The upper region, the center region and the anchor are integral with each other and arranged in the vertical direction relative to each other. Also described is a composite part that uses the profiled retaining section.

Abstract: The invention relates to a composite part having a decor skin with a first and a second section, preferably each including leather, and a holding portion, wherein the first and second sections are connected to one another by a seam and a part region of the decor skin is connected to the holding portion. In accordance with the invention, the part region of the decor skin is preferably connected to the holding portion with material continuity in the region of the seam.

Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Allskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.

Abstract: The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.

Abstract: The present invention is directed toward, a data sink/data source data transmission device and data terminal device for a circuit-switched and packet-switched network, the ability to eliminate the logical separation between applications, which are based on the circuit-switched network (e.g., PSTN, ISDN), and applications, which are based on the packet-switched network, (e.g., Internet). To this end, a data transmission device for transmitting and receiving data into/from the circuit-switched network includes controllable switchover parts. This data transmission device is or can be assigned to a universally useable unit for automatically processing data and for transmitting and receiving data to/from the packet-switched network and is assigned or can be assigned to the at least one data terminal device for transmitting and receiving data into/from the circuit-switched network.