Abstract: An apparatus for circulatory isolation and treatment of a part of a patient's body includes a fluid circulation loop having a first end and a second end, a flow obstructer adapted for obstructing blood flow in a patient's blood vessel such that a body part or organ becomes circulatorily isolated from the circulation of the rest of the body, and a flow-through arrangement including first and second flow-through members respectively connected to the first and second ends of the fluid circulation loop, for providing the isolated part of the patient's body with a fluid connection to the fluid circulation loop, allowing circulation of a therapeutic fluid through the isolated body part.