Patents by Inventor Frank SCHMITGES

Frank SCHMITGES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide therapy for Wilson disease
    Patent number: 11578327
    Abstract: The present disclosure provides antisense oligonucleotides, compositions, and methods that target ATP7B exon 6 or a flanking intron, thereby modulating splicing of ATP7B pre-mRNA to increase the level of ATP7B mRNA molecules having exon 6, e.g., to provide a therapy for Wilson disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to an ATP7B target sequence in exon 6, a 5?-flanking intron, a 3?-flanking intron, or a combination of exon 6 and the 5?-flanking or 3?-flanking intron.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: February 14, 2023
    Assignee: Deep Genomics Incorporated
    Inventors: Daniele Merico, Erno Wienholds, Frank Schmitges, Matthew O'Hara
  • OLIGONUCLEOTIDE THERAPY FOR WILSON DISEASE
    Publication number: 20210032629
    Abstract: The present disclosure provides antisense oligonucleotides, compositions, and methods that target ATP7B exon 6 or a flanking intron, thereby modulating splicing of ATP7B pre-mRNA to increase the level of ATP7B mRNA molecules having exon 6, e.g., to provide a therapy for Wilson disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to an ATP7B target sequence in exon 6, a 5?-flanking intron, a 3?-flanking intron, or a combination of exon 6 and the 5?-flanking or 3?-flanking intron.
    Type: Application
    Filed: February 14, 2019
    Publication date: February 4, 2021
    Inventors: Daniele MERICO, Erno WIENHOLDS, Frank SCHMITGES, Matthew O'HARA