Patents by Inventor Frank Sipos

Frank Sipos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Benzylideneamphotericin B, its methyl ester and process for making water-soluble salts thereof
    Patent number: 4235993
    Abstract: New intermediates, namely, N-benzylideneamphotericin B, and its methyl ester, are employed in a new process for preparing water-soluble salts of amphotericin B, methyl ester, such as amphotericin B, methyl ester aspartate.
    Type: Grant
    Filed: February 21, 1979
    Date of Patent: November 25, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frank Sipos, Adam J. Keseleski
  • Amphotericin B methyl ester salts
    Patent number: 4041232
    Abstract: Amphotericin B methyl ester salts, such as salts formed by reaction with mono and dicarboxylic amino acids (such as aspartic acid, or glutamic acid or pyroglutamic acid), hydroxy carboxylic acids (such as lactic acid) and mono and dicarboxylic acids (such as acetic acid) are provided and have been found to be readily water-soluble and at least as stable and active as the parent ester compound.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: August 9, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frank Sipos, Adam J. Keseleski
  • Process for producing the methyl ester of amphotericin B
    Patent number: 4035567
    Abstract: A process is provided for producing amphotericin B methyl ester wherein amphotericin B is initially mixed and suspended in dimethylformamide or hexamethylphosphoric triamide for a predetermined period, and thereafter aqueous ammonia is slowly added to the mixture until a clear solution is obtained. The dissolved amphotericin B is then esterified with diazomethane in accordance with conventional procedures.
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: July 12, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Frank Sipos